Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 在庫あり | ¥ 7,500 |
5 mg | 在庫あり | ¥ 12,000 |
10 mg | 在庫あり | ¥ 17,500 |
25 mg | お問い合わせ | ¥ 36,500 |
50 mg | お問い合わせ | ¥ 60,500 |
100 mg | お問い合わせ | ¥ 95,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,500 |
説明 | BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). |
ターゲット&IC50 | LXRβ:14 nM, LXRα:68nM |
In vitro | BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM). |
In vivo | BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2]. |
別名 | XL652, EXEL04286652, XL 652, XL-652, BMS-788 |
分子量 | 509.06 |
分子式 | C28H29ClN2O3S |
CAS No. | 918348-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (117.86 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS-779788 918348-67-1 Metabolism Liver X Receptor Inhibitor BMS 788 Liver X receptor XL652 inhibit EXEL 04286652 BMS779788 LXR EXEL04286652 XL 652 EXEL-04286652 XL-652 BMS-788 BMS788 BMS 779788 inhibitor