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T1783 |
LXR-623
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LXR623,WAY 252623 |
Liver X Receptor
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LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. |
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T63723 |
LXR agonist 1
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LXR (Liver X receptor) agonist 1 is a potent agonist of LXR, capable of acting on LXR-α (AC50: 1.5 nM) and LXR-β (AC50: 12 nM). LXR agonist 1 has shown research potential in atherosclerosis. |
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T64171 |
LXR antagonist 2
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LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target ge... |
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T64148 |
LXR agonist 2
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LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR. |
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T83128 |
Aminooxy CatB-LXR
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Compound 10, Aminooxy CatB-LXR, constitutes an agent-linker conjugate for antibody-drug conjugates (ADC) [1]. |
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T5178 |
AZ876
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Liver X Receptor
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AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. |
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T15427 |
GSK2033
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Liver X Receptor
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GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively). |
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T16930 |
SR9238
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Liver X Receptor
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SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). |
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T1801 |
SR9243
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Liver X Receptor
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SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect. |
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T27478 |
GSK3987
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Liver X Receptor
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GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. |
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T7768 |
RGX-104
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RGX-104 free Acid |
Liver X Receptor
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RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) |
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T6310 |
GW3965 hydrochloride
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GW3965 HCl |
Liver X Receptor
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GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM). |
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T5128 |
RGX-104 hydrochloride
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SB742881,RGX-104 HCl |
Liver X Receptor
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RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene. |
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T3970 |
BMS-779788
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XL652,EXEL04286652,XL 652,XL-652,BMS-788 |
Liver X Receptor
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BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). |
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T6690 |
T0901317
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Apoptosis
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FXR
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Liver X Receptor
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ROR
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T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). |
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T63989 |
LXRβ agonist-3
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LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM). LXRβ agonist-3 effectively inhibits U87EGFRvIII cells (IC50: 3.75 μM). . |
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T11899 |
LXRβ agonist-2
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Others
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LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM. |
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T68316 |
GAC0003A4
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GAC0001E5 |
Liver X Receptor
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GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits the proliferation of PDAC cells in a dose-dependent manner.G... |
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T16792 |
Rovazolac
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ALX-101 |
Liver X Receptor
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Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis. |
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T63896 |
BE1218
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Liver X Receptor
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BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively. |
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T40898 |
DMHCA
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DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in... |
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T6310L |
GW3965
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GW3965 is a potent, selective agonist of liver X receptor (LXR) with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3]. |
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T68696 |
AZ-2
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AZ-2 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-2 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity. |
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T69671 |
SR1903 TFA
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SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec... |
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T36130 |
22(S)-hydroxy Cholesterol
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22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol |
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22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc... |
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T68668 |
AZ-1
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AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity. |
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T35638 |
SR 1903
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SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al... |
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T74147 |
Larsucosterol (trimethylamine)
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Larsucosterol (DUR-928) trimethylamine, a metabolite of cholesterol, functions as a powerful liver X receptor (LXR) antagonist, effectively reducing lipogenesis and inhibiting cholesterol biosynthesis. It achieves this b... |
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T83765 |
Dendrogenin A
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DDA |
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Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6α-epoxy cholest... |
