Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 40,500 | |||
5 mg | 在庫あり | ¥ 85,500 | |||
10 mg | 在庫あり | ¥ 128,000 | |||
25 mg | 在庫あり | ¥ 206,000 | |||
50 mg | 在庫あり | ¥ 280,000 | |||
100 mg | 在庫あり | ¥ 379,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 91,500 |
説明 | BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer. |
In vitro | BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 exhibts IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ~20 % max inhibition). |
In vivo | BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) shows dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses |
別名 | BMS986242 |
分子量 | 410.91 |
分子式 | C24H24ClFN2O |
CAS No. | 1923844-48-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (608.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BMS-986242 1923844-48-7 Metabolism Indoleamine 2,3-Dioxygenase (IDO) IDO glucuronidation potent cancer Inhibitor BMS 986242 inhibit BMS986242 active selective orally inhibitor