Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
説明 | C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM. |
ターゲット&IC50 | STAT3:4-7 μM |
In vitro | For apoptosis studies, AML cell lines and primary samples are treated for 24 hours with C188-9, then apoptotic cells are quantified by FACS analysis for annexin V-labeled cells. The EC50s for apoptosis induction are quite variable, ranging from 6 μM to over 50 μM |
In vivo | In an analysis of approximately 13,528 discernible genes, C188 influences the expression of 37 gene transcripts (17 downregulated and 20 upregulated, false discovery rate (fdr)<0.01, fold change≥1.5), including 7 known targets of STAT3. Conversely, C188-9 exhibits a broader impact, modifying the expression of 384 genes related to oncogenesis (95 down- and 289 up-regulated), 76 of which are regulated by STAT3 (38 down-regulated and 38 up-regulated). Notably, C188-9 treatment downregulates 24 out of 38 genes (63%) previously identified as upregulated by STAT3. Furthermore, C188-9 downregulates an additional 10 genes (fdr <0.01, fold change≥1.5) known to be upregulated by STAT1, suggesting that 83.3% (40 out of 48) of the genes downregulated by C188-9 are positively regulated by STAT1. This includes sixteen genes co-regulated by both STAT3 and STAT1. The findings suggest that C188-9's modulation of gene transcript levels in head and neck squamous cell carcinoma (HNSCC) tumors may be attributed to its dual influence on STAT3 and STAT1 pathways. |
別名 | TTI-101 |
分子量 | 471.52 |
分子式 | C27H21NO5S |
CAS No. | 432001-19-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (127.25 mM)
You can also refer to dose conversion for different animals. 詳細
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C188-9 432001-19-9 Apoptosis JAK/STAT signaling Stem Cells STAT C1889 TTI101 Inhibitor C188 9 C-188-9 TTI-101 inhibit TTI 101 inhibitor