Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 9,000 | |||
50 mg | 在庫あり | ¥ 13,000 | |||
100 mg | 在庫あり | ¥ 18,500 | |||
200 mg | 在庫あり | ¥ 30,500 | |||
500 mg | 在庫あり | ¥ 50,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
ターゲット&IC50 | COX-2(human):1.3 nM (IC50, in CHO cells), COX-1 (ovine):5.1 nM (IC50), COX-1 (ovine):0.84 nM (IC50), COX-1 (human):4 nM (IC50, in CHO cells) |
In vitro | The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. |
別名 | CGP-45840B, Cataflam, Voltfast |
分子量 | 334.24 |
分子式 | C14H10Cl2KNO2 |
CAS No. | 15307-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL (29.91 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (164.55 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Diclofenac Potassium 15307-81-0 Apoptosis Immunology/Inflammation Neuroscience Others COX CHO CGP-45840B caspase COX-1 cascade anti-inflammatory neural cells stem ovine NSCs Diclofenac Inhibitor Cataflam inhibit Voltfast Cyclooxygenase COX-2 inhibitor