|
T7900 |
BAY-474
|
|
c-Met/HGFR
|
|
BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe |
|
T3624 |
A-366
|
A 366,A366 |
Epigenetic Reader Domain
,
Histone Methyltransferase
|
|
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... |
|
T15784 |
LP99
|
|
Epigenetic Reader Domain
|
|
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9). |
|
T1972 |
GSK-5959
|
|
Epigenetic Reader Domain
|
|
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family... |
|
T5198 |
Bobcat339
|
Bobcat339 hydrochloride |
DNA Methyltransferase
|
|
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
|
T6879 |
LLY-507
|
LLY507,LLY 507 |
Histone Methyltransferase
|
|
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2. |
|
T7194 |
CM-272
|
|
Apoptosis
,
DNA Methyltransferase
,
Histone Methyltransferase
|
|
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. |
|
T79131 |
KAT modulator-1
|
|
Histone Acetyltransferase
|
|
KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1]. |
|
T61012 |
Bobcat339 hydrochloride
|
|
|
|
Bobcat339 hydrochloride can be used in the field of epigenetics and as a starting point for new therapeutics targeting DNA methylation and gene transcription. Bobcat339 hydrochloride is a potent and selective cytosine-ba... |
