Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 26,000 | |||
50 mg | 在庫あり | ¥ 42,000 | |||
100 mg | 在庫あり | ¥ 66,500 | |||
200 mg | お問い合わせ | ¥ 98,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,500 |
説明 | Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood. |
ターゲット&IC50 | HMG-CoA reductase:0.47 mM |
In vitro | In the treatment of arteriosclerosis in rats, Clinofibrate significantly reduces high plasma cholesterol levels. When used in CAPD patients, it effectively decreases very low-density lipoprotein levels. Typically, Clinofibrate (600 mg/daily) reduces serum triglycerides by 36% and very low-density lipoprotein triglycerides by 48%. Additionally, it ameliorates abnormalities in low-density and high-density lipoprotein compositions, markedly increasing the content of high-density lipoprotein cholesterol. |
In vivo | Clinofibrate, with an IC50 of 40 μM, acts on the activity of human liver 3α-hydroxysteroid dehydrogenase. |
別名 | S-8527, Lipoclin |
分子量 | 468.58 |
分子式 | C28H36O6 |
CAS No. | 30299-08-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 87 mg/mL (185.7 mM)
Ethanol: 87 mg/mL (185.7 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Clinofibrate 30299-08-2 Autophagy Metabolism HMG-CoA Reductase S 8527 S-8527 HMG-CoA Reductase (HMGCR) inhibit Inhibitor S8527 Lipoclin inhibitor