Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
説明 | Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. |
ターゲット&IC50 | HMG-CoA reductase:8 nM |
In vitro | In a rabbit model, daily administration of Fluvastatin (10 mg/kg) significantly reversed the inhibition of acetylcholine-induced vasodilation, effectively reducing hyperlipidemia. |
In vivo | In human aortic smooth muscle cells, Fluvastatin (100 nM) reduces the formation of superoxide anion radicals activated by angiotensin II. In CHL/IU cells, Fluvastatin (8 μM) offers protection against DNA damage. It significantly inhibits the formation of thiobarbituric acid-reactive substances in lipid peroxidation initiated by divalent iron ions (IC50=12 μM). Fluvastatin (1-100 μM) can inhibit lipid peroxidation mediated by peroxyl radicals induced by 2,2'-azobis(2-amidinopropane) dihydrochloride and 2,2'-azobis. |
別名 | XU 62320 sodium, XU-62-320, Fluvastatin sodium salt |
分子量 | 433.45 |
分子式 | C24H25FNNaO4 |
CAS No. | 93957-55-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10.8 mg/mL (25 mM)
DMSO: 43.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Fluvastatin sodium 93957-55-2 Apoptosis Autophagy Metabolism Ferroptosis HMG-CoA Reductase Inhibitor HMG-CoA Reductase (HMGCR) Nrf2-dependent muscle pathway XU 62320 sodium HMG-CoA smooth inhibit antioxidant XU 62-320 stress reductase Fluvastatin vascular oxidative XU-62-320 Fluvastatin sodium salt inhibitor