Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
説明 | Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
ターゲット&IC50 | Ribonucleotide reductase:65 nM |
In vitro | In athymic nude mice or severe combined immunodeficient (SCID) mice, Clofarabine demonstrates inhibitory effects on various subcutaneously transplanted human tumor xenografts. |
In vivo | In lymphocytes from chronic lymphocytic leukemia, 10 μM Clofarabine inhibits the repair induced by 4-hydroperoxycyclophosphamide with a peak inhibition at an intracellular concentration of 5 μM. Across a range of leukemia and solid tumor cell lines, Clofarabine demonstrates potent growth inhibition and cytotoxicity (IC50= 0.028–0.29 μM). |
別名 | Clofarex, Evoltra, Clolar |
分子量 | 303.68 |
分子式 | C10H11ClFN5O3 |
CAS No. | 123318-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Clofarabine 123318-82-1 Apoptosis Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog DNA/RNA Synthesis analogue Inhibitor Clofarex ribonucleotide reductase nucleoside inhibit Evoltra Clolar inhibitor