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Search Results for " DNA-binding "

ターゲット

ROR

135

阻害剤

天然化合物

104

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T4050	GSK2981278	ROR gama modulator 1	ROR
	GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).		ROR
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T15486	HLM006474		Others
	HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 µM in A375 cells).		Others
T12019	Methylproamine		Others
	Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.		Others
T64372	DB722		Others
	DB722 is a furamidine analogues with DNA binding activity. DB722 shows antiproliferative activity.		Others
T60051	VPC-18005		Others
	VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.		Others
T7388	GSK805		ROR
	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi...		ROR
T19827	DAPI Dihydrochloride	FxCycle Violet,4',6-diamidino-2-phenylindole	Others
	DAPI Dihydrochloride (FxCycle Violet) is a cell-permeable fluorescent probe by binding in the minor grove of A-T rich sequences of DNA, used to stain DNA and chromosomes, with a preference for adenine and thymine rich DN...		Others
T8334	CADD522	MFCD00167693	Others
	CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity		Others
T9879	Hydroxystilbamidine	Oxistilbamidinum,(E)-hydroxystilbamidine,2-Hydroxy-4,4'-diguanylstilbene,Bis(8-hydroxyquinolinium) sulphate	Others
	Hydroxystilbamidine ((E)-hydroxystilbamidine), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.		Others
T10268	AGX51		Others
			Others
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T11332	FUBP1-IN-1	FUBP1–IN-1	Others
	FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-strand target DNA FUSE sequence.		Others
T4025	HMN-154	HMN154	Others
	HMN-154 is a novel benzenesulfonamide anticancer compound. It is able to interact with NF-YB and interrupt the binding of NF-Y heterotrimer to DNA.		Others
T27246	EG1		Others
	EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.		Others
T27613	InS3-54-A26		STAT
	inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.		STAT
T23133	Pentamidine		Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T4023	L-Argininamide dihydrochloride	H-Arg-NH2.2HCl	Others
	L-Argininamide dihydrochloride (H-Arg-NH2.2HCl) is used as a model compound in studies of the physicochemical characteristic of ligand binding DNA aptamers and their potential development as fluorescent aptasensors.		Others
T8554	KCC-07		DNA Alkylator/Crosslinker
	KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes...		DNA Alkylator/Crosslinker
T1643	Penciclovir	BRL 39123,VSA 671	HCV Protease , Antifection , HSV
	Penciclovir (BRL 39123) is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the ...		HCV Protease , Antifection , HSV
T2627	Nolatrexed dihydrochloride	Thymitaq,AG 337	DNA/RNA Synthesis
	Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidyla...		DNA/RNA Synthesis
T15507	Hycanthone	Etrenol(mesylate),Win 249-33	DNA/RNA Synthesis , Topoisomerase , Parasite
	Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibit...		DNA/RNA Synthesis , Topoisomerase , Parasite
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T2628	RI-2		DNA/RNA Synthesis
	RI-2 is an optimized RAD51 inhibitor with an IC50 of 44.17 μM in the standard DNA binding assay; specifically inhibits HR(Homologous recombination) repair in human cells.		DNA/RNA Synthesis
T0110	Zalcitabine	Dideoxycytidine,ddC,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine	HIV Protease , Reverse Transcriptase
	Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to rever...		HIV Protease , Reverse Transcriptase
T11090L1	Aldoxorubicin hydrochloride	Aldoxorubicin hydrochloride (1361644-26-9 Free base）	Topoisomerase
	Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibi...		Topoisomerase
T70873	M3541		Apoptosis , ATM/ATR
	M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che...		Apoptosis , ATM/ATR
T15146	DNA2 inhibitor C5		Others
	DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress and it also is a competitive and specific inhibitor of DNA2 nuclease activity (IC50: 20 μM)...		Others
T2169	Zebularine	NSC309132,4-Deoxyuridine	DNA Methyltransferase , Autophagy
	Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2...		DNA Methyltransferase , Autophagy
T5416	T-5224		MMP
	T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.		MMP
T4005	FDI-6	FDI6,FDI 6	Others
	FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6(FDI6) binds to the FOXM1 protein and specifically downregulates FOXM1-activated genes.		Others
T77520	AOH1996		Apoptosis , DNA/RNA Synthesis
	AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...		Apoptosis , DNA/RNA Synthesis
T17009	TC-S 7009		HIF
	TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene e...		HIF
T3157	COH29	RNR Inhibitor COH29	DNA/RNA Synthesis
	COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i...		DNA/RNA Synthesis
T15601	IT-901		Others
	IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC50 for NF-κB and c-Rel binding to DNA of 0.1 µM and 3 µM, respectively.IT-901 is a naphthalene thiobarbiturate derivative with antitumor activ...		Others
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
T19003	HOE-S 785026 trihydrochloride	meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)
	HOE-S 785026 trihydrochloride is a live cell labeling dye that binds nucleic acids by binding to the minor groove in DNA double strands. HOE-S 785026 trihydrochloride tends to bind to A/T-rich DNA strands (fluorescence i...
T8799	(E/Z)-IT-603	IT603	Others , NF-κB
	(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity.		Others , NF-κB
T3636	(E)-SIS3	SIS3,SIS3 HCl	TGF-beta/Smad
	(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...		TGF-beta/Smad
T10964	DB1976		Apoptosis , Others
	DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA comp...		Apoptosis , Others
T77743	TT-012		Others
	TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the g...		Others
T24925	UNC-2170	UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others
	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.		Others
T1933	NVP 231		Apoptosis , ERK
	NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.		Apoptosis , ERK
T8873	Bractoppin		Others , DNA/RNA Synthesis
	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi...		Others , DNA/RNA Synthesis
T41068	P53R3		p53
	P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferativ...		p53
T15212	Emamectin Benzoate	MK-244	Apoptosis , Reactive Oxygen Species , GABA Receptor , Parasite
	Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.
T23840	BUR1	BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1	CDK
	BUR1 is a selective BMP upregulator that acts by increasing the expression of Inhibitor of DNA binding 1 and inducing BMP2 and PTGS2 expression.		CDK
T68359	DB1255
	DB1255 is a ERG/DNA binding inhibitor which targets the DNA-binding activity of the human ERG transcription factor.
T30486	BMPSP
	BMPSP is a fluorescent DNA groove binding probe.
T23754	Argininamide	L-Arginamide,L-Argininamide,L-Arginine amide
	Argininamide is used in studies of the physicochemical characteristic of ligand binding DNA aptamers.

Compounds

GSK2981278

T4050

Synonym: ROR gama modulator 1

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Synonym: FxCycle Violet,4',6-diamidino-2-phenylindole

Target: Others

CADD522

T8334

Synonym: MFCD00167693

Target: Others

Hydroxystilbamidine

T9879

Synonym: Oxistilbamidinum,(E)-hydroxystilbamidine,2-Hydroxy-4,4'-diguanylstilbene,Bis(8-hydroxyquinolinium) sulphate

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

L-Argininamide dihydrochloride

T4023

Synonym: H-Arg-NH2.2HCl

Target: DNA Alkylator/Crosslinker

Penciclovir

T1643

Synonym: BRL 39123,VSA 671

Target: HCV Protease, Antifection, HSV

Nolatrexed dihydrochloride

T2627

Synonym: Thymitaq,AG 337

Target: DNA/RNA Synthesis

Hycanthone

T15507

Synonym: Etrenol(mesylate),Win 249-33

Target: DNA/RNA Synthesis, Topoisomerase, Parasite

Target: DNA/RNA Synthesis

Zalcitabine

T0110

Synonym: Dideoxycytidine,ddC,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine

Target: HIV Protease, Reverse Transcriptase

Aldoxorubicin hydrochloride

T11090L1

Synonym: Aldoxorubicin hydrochloride (1361644-26-9 Free base）

Target: Topoisomerase

M3541

T70873

Synonym:

Target: Apoptosis, ATM/ATR

Synonym: NSC309132,4-Deoxyuridine

Target: DNA Methyltransferase, Autophagy

Target: Apoptosis, DNA/RNA Synthesis

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Lenalidomide hemihydrate

T22922

Synonym:

Target: TNF, Ligand for E3 Ligase, Molecular Glues

HOE-S 785026 trihydrochloride

T19003

Synonym: meta-Hoechst trihydrochloride,Meta-Hoechst trihydrochloride,HOE-S 785026 trihydrochloride (132869-83-1 free base)

Target: Others, NF-κB

(E)-SIS3

T3636

Synonym: SIS3,SIS3 HCl

Target: TGF-beta/Smad

DB1976

T10964

Synonym:

Target: Apoptosis, Others

Synonym: UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate

Target: Apoptosis, ERK

Bractoppin

T8873

Synonym:

Target: Others, DNA/RNA Synthesis

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite

BUR1

T23840

Synonym: BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1

Synonym: L-Arginamide,L-Argininamide,L-Arginine amide

Target:

カタログ番号	製品名	別名	ターゲット
TWS1977	Kamebakaurin	Kamebakaurine	NF-κB
	1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...		NF-κB
T6995	Ochromycinone	STA 21,STA21,STA-21	Antibacterial , STAT
	Ochromycinone (STA 21) is a selective STAT3 inhibitor.		Antibacterial , STAT
T13592	Calf thymus DNA	DNA from calf thymus, Thymonucleic acid	DNA/RNA Synthesis
	Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) is a high-quality double-stranded template DNA extracted from the bovine thymus gland, which can be widely used in the study of DNA binding anticancer agents and ...		DNA/RNA Synthesis
T6228	Irinotecan	CPT-11,Topotecin,(+)-Irinotecan	Topoisomerase , Autophagy
	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...		Topoisomerase , Autophagy
TN2269	Tetramethylcurcumin		Apoptosis , STAT
	Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and e...		Apoptosis , STAT
T4893	Spermidine	N-(3-Aminopropyl)-1,4-diaminobutane,N-(4-Aminobutyl)-1,3-diaminopropane	Endogenous Metabolite
	Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). ...		Endogenous Metabolite
TN2165	Rubrofusarin gentiobioside	Rubrofusarin-6-O-beta-D-gentiobioside	ERK , NF-κB , TGF-beta/Smad
	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive...		ERK , NF-κB , TGF-beta/Smad
T5530	Mithramycin A	Plicamycin	DNA/RNA Synthesis
	Mithramycin A (Plicamycin), a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of various cancers by decreasing Sp1 protein. Specificity protein 1 (Sp1) is...		DNA/RNA Synthesis
T3829	Ginsenoside F3		Others , IFNAR , Interleukin
	Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1, type 2 cytokines in murine spleen cells. Ginsenoside-F3 enhances the NF-kappaB DNA binding activity induced by ConA in m...		Others , IFNAR , Interleukin
T30086	Anthragallol	Anthragallic acid,1,2,3-Trihydroxyanthraquinone	Others
	Anthragallol（1,2,3-Trihydroxyanthraquinone） displays cytotoxicity by binding to DNA.Anthragallol can be used as an analytical reagent in the production of brown pickling colors.		Others
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T38673	Sibiromycin
	Sibiromycin, a glycosylated pyrrolobenzodiazepines (PBDs) compound, is a naturally occurring and potent antitumor antibiotic. It exerts its activity by covalently binding to DNA in the minor groove at the NH2 of guanine.
T75634	Demycarosyl-3D-β-D-digitoxosylmithramycin SK
	Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity. It hinders tumor cell proliferation and growth by binding to and inhibiting DNA-binding proteins [1].
T15467	Helenalin		Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine ...		Others
T75527	Chrexanthomycin C
	Chrexanthomycin C, an orally active marine-derived natural product, exhibits significant bioactivities and shows a binding affinity for DNA [(G4C2)4 G4] with a dissociation constant (Kd) of 2.8 mM. This compound holds po...
T72152	Eicosapentaenoic Acid sodium	Timnodonic acid sodium,EPA sodium
	Eicosapentaenoic Acid (EPA) sodium, an orally active omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA), demonstrates a unique ability to demethylate DNA, thereby facilitating the re-expression of the tumor supp...
T83915	Norbixin hydrate
	Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of ...

天然物製品

Kamebakaurin

TWS1977

Synonym: Kamebakaurine

Target: NF-κB

Ochromycinone

T6995

Synonym: STA 21,STA21,STA-21

Target: Antibacterial, STAT

Calf thymus DNA

T13592

Synonym: DNA from calf thymus, Thymonucleic acid

Target: DNA/RNA Synthesis

Irinotecan

T6228

Synonym: CPT-11,Topotecin,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Tetramethylcurcumin

TN2269

Synonym:

Target: Apoptosis, STAT

Spermidine

T4893

Synonym: N-(3-Aminopropyl)-1,4-diaminobutane,N-(4-Aminobutyl)-1,3-diaminopropane

Target: Endogenous Metabolite

Rubrofusarin gentiobioside

TN2165

Synonym: Rubrofusarin-6-O-beta-D-gentiobioside

Target: ERK, NF-κB, TGF-beta/Smad

Mithramycin A

T5530

Synonym: Plicamycin

Target: DNA/RNA Synthesis

Ginsenoside F3

T3829

Synonym:

Target: Others, IFNAR, Interleukin

Anthragallol

T30086

Synonym: Anthragallic acid,1,2,3-Trihydroxyanthraquinone

Target: Others

2-Methoxyestradiol

T2220

Synonym: NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

Demycarosyl-3D-β-D-digitoxosylmithramycin SK

Eicosapentaenoic Acid sodium

T72152

Synonym: Timnodonic acid sodium,EPA sodium

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03487	DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His)	Serratia marcescens	E. coli
	A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensi...
TMPH-00668	DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recombinant (His & SUMO)	E. coli	E. coli
	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recom...
TMPH-00616	DNA-binding protein H-NS Protein, E. coli, Recombinant (His)	E. coli	E. coli
	A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstrea...
TMPH-00898	Human adenovirus C serotype 5 DNA-binding protein (His)	HAdV-5	Baculovirus Insect Cells
	Human adenovirus C serotype 5 DNA-binding protein (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 42.3 kDa and the accession number is P03265.
TMPH-00896	Human adenovirus C serotype 2 DNA-binding protein (His)	HAdV-2	E. coli
	Human adenovirus C serotype 2 DNA-binding protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.8 kDa and the accession number is P03264.
TMPH-00039	Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)	Agrobacterium fabrum	E. coli
	Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence compos...
TMPH-03193	Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)	Pyrococcus furiosus	E. coli
	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DN...
TMPH-00525	DsDNA-binding protein A Protein, Enterobacteria phage T4, Recombinant (His & Myc)	Enterobacteria phage T4	E. coli
	May play a role in transcription of several T4 genes. Binds double-stranded DNA and interacts preferentially with T4 late promoter regions. DsDNA-binding protein A Protein, Enterobacteria phage T4, Recombinant (His & Myc...
TMPJ-01061	Nucleobindin-2 Protein, Human, Recombinant	Human	E. coli
	Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulat...
TMPJ-01328	ZBP1 Protein, Human, Recombinant (His)	Human	E. coli
	Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of vir...
TMPJ-00887	NFKB1 Protein, Human, Recombinant (His)	Human	E. coli
	The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radica...
TMPH-01091	CHD1L Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal...
TMPJ-01241	DTD1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is...
TMPJ-00904	NFYA Protein, Human, Recombinant (GST)	Human	E. coli
	NFYA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 55 KDa and the accession number is P23511-2.
TMPJ-00903	NFYA Protein, Human, Recombinant	Human	E. coli
	NFYA Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 40 and 60 and 70 KDa and the accession number is P23511-2.
TMPY-02287	Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-00541	LON PROTEASE Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and natura...
TMPY-00117	FGF-16 Protein, Human, Cynomolgus, Recombinant	Human,Cynomolgus	Baculovirus Insect Cells
	Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the ME...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPH-03040	HupB Protein, MenB, Recombinant (His)	MenB	E. coli
	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
TMPJ-01376	ZNF70 Protein, Human, Recombinant (His)	Human	E. coli
	Zinc Finger Protein 70 (ZNF70) is a member of the krueppel C2H2-type zinc-finger protein family. ZFN70 is localized to the cell nucleus and contains eleven C2H2-type zinc fingers. ZFN70 has sequence-specific DNA binding ...
TMPY-02433	APE1/APEX1 Protein, Human, Recombinant (His)	Human	E. coli
	The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diest...
TMPH-02318	ZBTB32 Protein, Human, Recombinant (His)	Human	E. coli
	DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from bin...
TMPY-01306	DNMT2 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	DNMT2, also known as tRNA (cytosine-5-)-methyltransferase, DNA methyltransferase homolog HsaIIP, and TRDMT1, is a member of the DNA methyltransferase family of enzymes. DNMT2 enzymes have been widely conserved during evo...
TMPJ-01214	ZNF100 Protein, Human, Recombinant (His)	Human	E. coli
	Zinc Finger Protein 100 (ZNF100) is part of the krueppel C2H2-type zinc-finger protein family. ZNF100 contains 12 C2H2-type zinc fingers and 1 KRAB domain. ZNF100 is a DNA-binding protein domain consisting of zinc finger...
TMPJ-00668	HMGB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	High Mobility Group Protein B3 (HMGB3) belongs to the HMGB family. Members of the HMG box subfamily are thought to be have an important role in DNA replication, nucleosome assembly and transcription. HMGB3 binds preferen...
TMPY-02430	BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)	Human	E. coli
	The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexe...
TMPH-01239	XPC Protein, Human, Recombinant (His)	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPY-03794	CEBP gamma Protein, Human, Recombinant (His)	Human	E. coli
	CEBPG, also known as CEBP gamma, is a transcription factor which belongs to the CEBP family. Members of this family regulate viral and cellular CCAAT/enhancer element-mediated transcription. CEBP proteins contain the bZI...
TMPJ-00918	HMGB2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cell...
TMPH-03471	HupB Protein, Salmonella typhi, Recombinant (His & Myc & SUMO)	Salmonella typhi	E. coli
	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. HupB Protein, Salmonella typhi, Recombinant (His & Myc & SUM...
TMPH-00530	SSB Protein, Enterobacteria phage T4, Recombinant (His & Myc)	Enterobacteria phage T4	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair (Probable). Coats the lagging-strand ssDNA as the replication fork advances. Stimulates the activities of viral DN...
TMPH-03041	IHF-alpha Protein, MenB, Recombinant (His)	MenB	E. coli
	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
TMPH-00532	SSB Protein, Enterobacteria phage T7, Recombinant	Enterobacteria phage T7	P. pastoris (Yeast)
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPY-02228	P53 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...
TMPJ-00516	OBhFc1 Protein, Human, Recombinant (His)	Human	E. coli
	CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA ...
TMPH-00612	MutL Protein, E. coli, Recombinant (His)	E. coli	E. coli
	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable co...
TMPJ-00464	APE Protein, Human, Recombinant	Human	E. coli
	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete re...
TMPH-00531	SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)	Enterobacteria phage T7	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPH-02519	API5 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently supp...
TMPH-00646	LexA repressor Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA int...
TMPJ-01179	SWSAP1 Protein, Human, Recombinant (His)	Human	E. coli
	SWSAP1 is a nucleus ATPase protein, interacts with ZSWIM7 and forms a functional complex. The complexs involved in homologous recombination repair and stabilizes each other. SWS1AP1 also interacts with RAD51, RAD51B, RAD...
TMPH-00106	TBP1 Protein, Arabidopsis thaliana, Recombinant (His & SUMO)	Arabidopsis thaliana	E. coli
	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a ro...
TMPH-03042	IHF-beta Protein, MenB, Recombinant (His)	MenB	E. coli
	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. IHF-beta Protein, MenB, ...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His)	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ...
TMPH-00082	DREB2C Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and abscisic acid-inducible transcription. DREB2C Protein, Arabidopsis th...
TMPY-03504	CBFB Protein, Human, Recombinant (His)	Human	E. coli
	CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and os...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-01251	DUSP26 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis...
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DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His)

TMPH-03487

Species: Serratia marcescens

Expression System: E. coli

DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recombinant (His & SUMO)

TMPH-00668

Species: E. coli

Expression System: E. coli

DNA-binding protein H-NS Protein, E. coli, Recombinant (His)

TMPH-00616

Species: E. coli

Expression System: E. coli

Human adenovirus C serotype 5 DNA-binding protein (His)

TMPH-00898

Species: HAdV-5

Expression System: Baculovirus Insect Cells

Human adenovirus C serotype 2 DNA-binding protein (His)

TMPH-00896

Species: HAdV-2

Expression System: E. coli

Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)

TMPH-00039

Species: Agrobacterium fabrum

Expression System: E. coli

Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)

TMPH-03193

Species: Pyrococcus furiosus

Expression System: E. coli

DsDNA-binding protein A Protein, Enterobacteria phage T4, Recombinant (His & Myc)

TMPH-00525

Species: Enterobacteria phage T4

Expression System: E. coli

Nucleobindin-2 Protein, Human, Recombinant

TMPJ-01061

Species: Human

Expression System: E. coli

ZBP1 Protein, Human, Recombinant (His)

TMPJ-01328

Species: Human

Expression System: E. coli

NFKB1 Protein, Human, Recombinant (His)

TMPJ-00887

Species: Human

Expression System: E. coli

CHD1L Protein, Human, Recombinant (His & SUMO)

TMPH-01091

Species: Human

Expression System: E. coli

DTD1 Protein, Human, Recombinant (His)

TMPJ-01241

Species: Human

Expression System: HEK293 Cells

NFYA Protein, Human, Recombinant (GST)

TMPJ-00904

Species: Human

Expression System: E. coli

NFYA Protein, Human, Recombinant

TMPJ-00903

Species: Human

Expression System: E. coli

Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)

TMPY-02287

Species: Human

Expression System: Baculovirus Insect Cells

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

TMPY-02953

Species: Human

Expression System: HEK293 Cells

LON PROTEASE Protein, E. coli, Recombinant (His)

TMPY-00541

Species: E. coli

Expression System: E. coli

FGF-16 Protein, Human, Cynomolgus, Recombinant

TMPY-00117

Species: Human,Cynomolgus

Expression System: Baculovirus Insect Cells

C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

HupB Protein, MenB, Recombinant (His)

TMPH-03040

Species: MenB

Expression System: E. coli

ZNF70 Protein, Human, Recombinant (His)

TMPJ-01376

Species: Human

Expression System: E. coli

APE1/APEX1 Protein, Human, Recombinant (His)

TMPY-02433

Species: Human

Expression System: E. coli

ZBTB32 Protein, Human, Recombinant (His)

TMPH-02318

Species: Human

Expression System: E. coli

DNMT2 Protein, Human, Recombinant (GST)

TMPY-01306

Species: Human

Expression System: Baculovirus Insect Cells

ZNF100 Protein, Human, Recombinant (His)

TMPJ-01214

Species: Human

Expression System: E. coli

HMGB3 Protein, Human, Recombinant (His)

TMPJ-00668

Species: Human

Expression System: HEK293 Cells

BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)

TMPY-02430

Species: Human

Expression System: E. coli

XPC Protein, Human, Recombinant (His)

TMPH-01239

Species: Human

Expression System: E. coli

CEBP gamma Protein, Human, Recombinant (His)

TMPY-03794

Species: Human

Expression System: E. coli

HMGB2 Protein, Human, Recombinant (His)

TMPJ-00918

Species: Human

Expression System: HEK293 Cells

HupB Protein, Salmonella typhi, Recombinant (His & Myc & SUMO)

TMPH-03471

Species: Salmonella typhi

Expression System: E. coli

SSB Protein, Enterobacteria phage T4, Recombinant (His & Myc)

TMPH-00530

Species: Enterobacteria phage T4

Expression System: E. coli

IHF-alpha Protein, MenB, Recombinant (His)

TMPH-03041

Species: MenB

Expression System: E. coli

SSB Protein, Enterobacteria phage T7, Recombinant

TMPH-00532

Species: Enterobacteria phage T7

Expression System: P. pastoris (Yeast)

p53 Protein, Cynomolgus, Recombinant

TMPY-02228

Species: Cynomolgus

Expression System: E. coli

OBhFc1 Protein, Human, Recombinant (His)

TMPJ-00516

Species: Human

Expression System: E. coli

MutL Protein, E. coli, Recombinant (His)

TMPH-00612

Species: E. coli

Expression System: E. coli

APE Protein, Human, Recombinant

TMPJ-00464

Species: Human

Expression System: E. coli

SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)

TMPH-00531

Species: Enterobacteria phage T7

Expression System: E. coli

API5 Protein, Mouse, Recombinant (His & Myc)

TMPH-02519

Species: Mouse

Expression System: E. coli

LexA repressor Protein, E. coli, Recombinant (His & SUMO)

TMPH-00646

Species: E. coli

Expression System: E. coli

SWSAP1 Protein, Human, Recombinant (His)

TMPJ-01179

Species: Human

Expression System: E. coli

TBP1 Protein, Arabidopsis thaliana, Recombinant (His & SUMO)

TMPH-00106

Species: Arabidopsis thaliana

Expression System: E. coli

IHF-beta Protein, MenB, Recombinant (His)

TMPH-03042

Species: MenB

Expression System: E. coli

ETS1 Protein, Human, Recombinant (His)

TMPJ-00854

Species: Human

Expression System: E. coli

DREB2C Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00082

Species: Arabidopsis thaliana

Expression System: E. coli

CBFB Protein, Human, Recombinant (His)

TMPY-03504

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & MBP)

TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

DUSP26 Protein, Human, Recombinant (His & SUMO)

TMPH-01251

Species: Human

Expression System: E. coli

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カタログ番号	製品名
L1380	Transcription Factor-Targeted Compound Library	695 compounds
	Well-chosen 695 compounds with unique structures targeting transcription factor;
L3800	NF-κB Signaling Compound Library	729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
L8300	Chromatin Modification Compound Library	250 compounds
	A unique collection of 250 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Transcription Factor-Targeted Compound Library

L1380

Compounds: 695

NF-κB Signaling Compound Library

L3800

Compounds: 729

Chromatin Modification Compound Library

L8300

Compounds: 250