Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.
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25 mg | 在庫あり | ¥ 8,500 | |||
50 mg | 在庫あり | ¥ 12,000 | |||
100 mg | 在庫あり | ¥ 14,500 | |||
500 mg | 在庫あり | ¥ 48,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,000 |
説明 | Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. |
ターゲット&IC50 | AChE:410 nM |
In vitro | Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3] |
In vivo | Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4] |
植物由来 |
別名 | Galantamine hydrobromide, Galanthamine HBr |
分子量 | 368.27 |
分子式 | C17H21NO3·HBr |
CAS No. | 1953-04-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (162.92 mM), Heating is recommended.
H2O: 7.4 mg/mL (20 mM)
You can also refer to dose conversion for different animals. 詳細
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Galanthamine hydrobromide 1953-04-4 Neuroscience AChR AChE Galantamine hydrobromide disease neurodegenerative Galanthamine HBr Inhibitor nAChR Nicotinic acetylcholine receptors Galantamine Hydrobromide disease (AD) Cholinesterase (ChE) acetylcholinesterase inhibit Galanthamine Hydrobromide Galantamine Alzheimer's Galanthamine inhibitor