191
29
64
11
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T13486 | Neurodegenerative Disorder-Targeting Compound 1 | Others | |
Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1]. | |||
T83527 | (Rac)-Neurodegenerative Disorder-Targeting Compound 1 | ||
(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor. | |||
T1880 | P7C3 | Others | |
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be... | |||
T8860 | DSRM-3716 | Androgen Receptor | |
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons. | |||
T22043 | BCATc Inhibitor 2 | Others | |
BCATc Inhibitor 2 exhibited an IC50 of 0.8 microM in the hBCATc assays; it is an active and selective inhibitor. BCATc Inhibitor 2 also blocked calcium influx into neuronal cells following inhibition of glutamate uptake,... | |||
T8849 | PF-9601N | MAO | |
PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD. | |||
T35856 | BMS-986176 | AAK1 (AP2 associated kinase 1) | |
AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A... | |||
T11095L | DREADD agonist 21 | 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor | |
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). | |||
T14080 | AA147 | ATF6-activator-147 | Others |
AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially trigge... | |||
T3707 | GNE-3511 | GNE3511 | DNA Alkylation , MAPK |
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors. | |||
T9272 | Xaliproden hydrochloride | Dopamine Receptor , 5-HT Receptor | |
Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist. | |||
T7426 | ALSTERPAULLONE | Apoptosis , GSK-3 , CDK | |
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec | |||
T9611 | PF-04802367 | GSK-3 | |
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ... | |||
T40019 | Thalidomide-5-NH2-CH2-COOH | Others | |
Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase. It is a ligand for E3 ligase and has potential for studying one or more diseases. | |||
T7706 | LY-404187 | GluR , iGluR | |
LY404187 is a positive allosteric modulator of AMPA receptors | |||
T22016 | A-582941 dihydrochloride | A 582941 | 5-HT Receptor , AChR |
A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial | |||
T6561 | Laquinimod | LAQ,ABR-215062 | Apoptosis , Others , NF-κB |
Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy. | |||
T9776 | TRPM4 inhibitor 8 | TRP/TRPV Channel | |
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. | |||
T9999 | Sirtuin modulator 2 | N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide | Others , Sirtuin |
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities. | |||
T8055 | TFEB activator 1 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612 | Others , Autophagy |
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease. | |||
T25531 | IND24 | IND-24,IND 24 | Antiviral |
IND24 has anti-prion activity and can be used to study neurodegenerative diseases. | |||
T27462 | GSK-239512 | GSK239512,GSK 239512 | Histamine Receptor |
GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders. | |||
T28856 | SSR180711 hydrochloride | SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl | AChR |
SSR180711 hydrochloride (SSR-180711A HCl) is a selective Alpha7 nicotinic acetylcholine partial agonist for the study of neurodegenerative and cognitive disorders. | |||
T10980 | DCPLA-ME | Methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoate,2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester,Methyl 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoate,DCPLA methyl ester | PKC |
DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator. | |||
T61809 | GSK-3β inhibitor 11 | GSK-3 | |
GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM. This compound demonstrates potential utility in the field of neurodegen... | |||
T60932 | MAO-B-IN-8 | MAO | |
MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically des... | |||
T73270 | GSK3-IN-2 | GSK-3 | |
GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases. | |||
T62750 | TREM2 agonist-2 | Others | |
TREM2 agonist-2 (I-192) is an orally active and potent myeloid triggered receptor 2 (TREM2) agonist for the study of neurodegenerative diseases. | |||
T77708 | Casein kinase 1δ-IN-7 | Casein Kinase | |
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease. | |||
T77709 | Casein kinase 1δ-IN-8 | Casein Kinase | |
Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type. | |||
T26684 | Auten-99 HBr | Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99 | Phosphatase |
Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th... | |||
T83646 | (S)-OSMI 3 | Ent-OSMI-3 | Others |
(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases. | |||
T67733 | BT44 | Others | |
BT44 is a novel, second-generation glial cell line_x0002_derived neurotropic factor mimetic with improved biological activity and is a lead compound for the treatment of neurodegenerative disorders. | |||
T40542 | Sinbaglustat | ACT-519276,Sinbaglustat,OGT2378 | Transferase |
Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain... | |||
T77566 | (3aR,9aR)-Fluparoxan | Adrenergic Receptor | |
(3aR,9aR)-Fluparoxan is a highly selective and potent adrenergic receptor α2B antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases. | |||
T36964 | BML-259 | CAY10554 | CDK |
BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases. | |||
T10012 | P7C3-OMe | Others | |
P7C3-OMe, a pro-neurogenic agent, has therapeutic benefits in neurodegenerative diseases. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer. | |||
T77565 | Fluparoxan hydrochloride | Adrenergic Receptor | |
Fluparoxan hydrochloride is a highly selective and potent α2-adrenoceptor antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases. | |||
T39566 | ZT-1a | Others | |
ZT-1a is a SPAK inhibitor.ZT-1a inhibits SPAK.ZT-1a can be used for the prevention and treatment of neurodegenerative and neurocognitive disorders. | |||
T16430 | Paliroden | SR 57667,SR 57667B | Others |
Paliroden is a non-peptide compound that can be taken orally and is used for supplementing neuro-nutrition. It stimulates the synthesis of endogenous neurotrophic factors and is employed in the research of neurodegenerat... | |||
T5463 | Verdiperstat | AZD3241,AZD 3241 | Glutathione Peroxidase |
Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders. | |||
T50092 | 1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride | 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride | Others |
1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3). It is used in studies of stem cell differentiation, tumors and neurodegenerativ... | |||
T10991 | Dehydronitrosonisoldipine | Calcium Channel | |
T13287 | VBIT-4 | VDAC | |
VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular dis... | |||
T67748 | ROCK-IN-5 | ROCK , ERK | |
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferative and neurodegenerative diseases research. | |||
T83628 | TNF/IFNγ-IN-1 | Antioxidant , TNF , COX | |
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer. | |||
T38654 | Cotosudil | ROCK | |
Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or neurodegenerative diseases or nerve damage. | |||
T16782 | Rolofylline | KW-3902,MK-7418,KF-15372 | Adenosine Receptor |
Rolofylline (KW-3902) is a selective adenosine A1 receptor antagonist used in the study of acute congestive heart failure and renal dysfunction, and in the study of neurodegenerative disorders. | |||
T62568 | IXA6 | IRE1 | |
IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's ... | |||
T72073 | AKOS037652256 | ||
AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxi... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TC0039 | Vasicinone | Others | |
Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiprolifer... | |||
T21883 | Gedunin | HSP | |
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation. | |||
TN6953 | Lignoceric Acid | tetracosanoic acid | Endogenous Metabolite |
Lignoceric Acid (tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid and a by-product of lignin production, which is synthesized in the developing brain. | |||
T6S1653 | Albiflorin | Alibiflorin | Reactive Oxygen Species |
1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ... | |||
TN2004 | Obtusin | MAO , Monoamine Oxidase | |
Obtusin is a natural product. | |||
T5728 | OsMundacetone | 4-(3,4-Dihydroxyphenyl)-3-buten-2-one | Apoptosis , Reactive Oxygen Species |
OsMundacetone (4-(3,4-Dihydroxyphenyl)-3-buten-2-one) is a natual product isolated from Rhizoma osmundae. | |||
T0086 | Galanthamine hydrobromide | Galantamine hydrobromide,Galanthamine HBr | AChR , AChE |
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. | |||
T22911 | β-N-methylamino-L-alanine hydrochloride | L-BMAA hydrochloride | Others |
β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. L-BMAA hydrochloride could cause amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases... | |||
T3026 | (-)-Huperzine A | HupA,Huperzine A | Apoptosis , AChR , AChE , iGluR |
(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr... | |||
T2999 | Gastrodin | Gastrodine | Others |
Gastrodin (Gastrodine), an anti-inflammatory polyphenol, is extracted from Chinese natural herbal Gastrodia elata Blume. and benefits neurodegenerative diseases. | |||
T3787 | Didymin | Isosakuranetin-7-O-rutinoside,Neoponcirin | Apoptosis , Others |
Didymin (Neoponcirin) has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule fo... | |||
T3911 | Pulchinenoside A | Anemoside A3 | Others |
Pulchinenoside A (Anemoside A3) is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases. | |||
T4S0536 | Bullatine A | Apoptosis , P2X Receptor | |
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treatment of neurodegenerative diseases such as arthritis. | |||
T4971 | 5'-DEOXYADENOSINE | 5′-dAdo | Endogenous Metabolite |
5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long be... | |||
TN6694 | 5,6-Benzoflavone | β-Naphthoflavone,beta-NF | Antioxidant |
5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a... | |||
T4956 | Tetrahydroxystilbene-2-O-β-D-glucoside | tetrahydroxyl diphenylethylene-2-o-gluco,EH-201 | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc... | |||
T5S1172 | Tiliroside | Tribuloside | Antioxidant |
1. Tiliroside (Tribuloside) shows anticarcinogenic activity. 2. Tiliroside shows hepatoprotective activity. 3. Tiliroside shows antioxidant and anti-inflammatory activity, can inhibit neuroinflammation in neurodegenerati... | |||
TN1831 | Macranthoside A | Kalopanaxsaponin H | Antioxidant |
Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective... | |||
T4S0797 | Berberine | Berberin,Umbellatine | Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy |
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3.... | |||
T2S2215 | Crebanine | Apoptosis , Others , Akt | |
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat... | |||
TN6422 | Ethyl (E)-ferulate | ||
Ethyl ferulate could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions. | |||
T19320 | FAPy-adenine | Others | |
TN6379 | 5,6,7,4'-Tetramethoxyflavanone | ||
5,6,7,4'-Tetramethoxyflavanone is a flavonoid compound isolated from Chromolaena odorata (L.) with neuroprotective activity and can be used in the study of neurodegenerative diseases. | |||
T38606 | Sinapine hydroxide | ||
Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective e... | |||
TN1428 | (+)-Balanophonin | Antioxidant , AChE | |
(+)-Balanophonin is a natural phenolic compound isolated from Passiflora edulis with antioxidant, anti-inflammatory, anticancer and anti-neurodegenerative activities, cholinesterase inhibition, and marginal inhibition of... | |||
TL0014 | Pinusolide | ERK , p38 MAPK , Calcium Channel , Lipoxygenase , PAFR , Caspase , JNK , AMPK | |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinus... | |||
TN5498 | 6,7,4'-Trihydroxyflavanone | Others | |
T75527 | Chrexanthomycin C | ||
Chrexanthomycin C, an orally active marine-derived natural product, exhibits significant bioactivities and shows a binding affinity for DNA [(G4C2)4 G4] with a dissociation constant (Kd) of 2.8 mM. This compound holds po... | |||
T81072 | Suffruticosol A | ||
Suffruticosol A, a neuroprotective compound isolated from the seeds of P. lactiflora [1], mitigates scopolamine-induced neurodegenerative cellular damage and improves hippocampal cholinergic function. Additionally, it pa... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-00135 | BDNF Protein, Human/Murine/Rat, Recombinant | Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I... | |||
TMPY-02767 | TPP1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Tripeptidyl-peptidase 1 (TPP1 / CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activit... | |||
TMPY-02881 | RAGE Protein, Human, Recombinant | Human | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-02927 | RAGE Protein, Human, Recombinant (His) | Human | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-02078 | HtrA2/Omi Protein, Human, Recombinant (His) | Human | E. coli |
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the ... | |||
TMPY-01355 | Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth an... | |||
TMPY-01694 | Clusterin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-01691 | Clusterin Protein, Human, Recombinant (CLU34, His) | Human | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-00767 | Cystatin C Protein, Human, Recombinant (His) | Human | HEK293 |
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio... | |||
TMPJ-00684 | SNCA Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's ... | |||
TMPK-00191 | PILRA Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does ... | |||
TMPH-01272 | TRIM9 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and ma... | |||
TMPK-01542 | HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01503 | HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01502 | HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPY-02043 | PARK7/DJ-1 Protein, Human, Recombinant (His) | Human | E. coli |
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress.... | |||
TMPJ-00278 | Clusterin Protein, Human, Recombinant (hFc & His) | Human | Human Cells |
Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis, heart, ovary, adrenal gland, brain and liver. Clusterin has been suggested to be involved in several basic bi... | |||
TMPK-01533 | HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPJ-00023 | SNCA Protein, Human, Recombinant (His) | Human | E. coli |
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist... | |||
TMPJ-00706 | SNCG Protein, Human, Recombinant | Human | E. coli |
Gamma-Synuclein (SNCG) is a member of the Synuclein protein family. Gamma-Synuclein is mostly expressed in the peripheral nervous system and retina. Gamma-Synuclein plays a role in neurofilament network integrity and may... | |||
TMPJ-00279 | Clusterin Protein, Human, Recombinant (His) | Human | Human Cells |
Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis, heart, ovary, adrenal gland, brain and liver. Clusterin has been suggested to be involved in several basic bi... | |||
TMPK-01535 | Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi) | Human & Mouse | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01530 | HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01498 | HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01534 | Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi) | Human & Mouse | HEK293 |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPY-00146 | RKIP/PEBP1 Protein, Human, Recombinant | Human | E. coli |
Phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that mon... | |||
TMPJ-00683 | SNCA Protein, Mouse, Recombinant | Mouse | E. coli |
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist... | |||
TMPY-00475 | PPT1 Protein, Human, Recombinant (His) | Human | HEK293 |
Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease. Mutations in palmitoyl protein thioesterase-1 (PPT1) have b... | |||
TMPJ-00828 | Tau-F Protein, Human, Recombinant | Human | E. coli |
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons... | |||
TMPY-04055 | PPT1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease. Mutations in palmitoyl protein thioesterase-1 (PPT1) have b... | |||
TMPJ-00761 | FTH Protein, Human, Recombinant (His) | Human | E. coli |
Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is ta... | |||
TMPY-03653 | CTRL Protein, Human, Recombinant (His) | Human | HEK293 |
CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is... | |||
TMPY-00131 | Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 |
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pi... | |||
TMPY-02653 | LRP-10 Protein, Human, Recombinant (hFc) | Human | HEK293 |
LRP10 (low-density lipoprotein Receptor Related Protein 10) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a low-density lipoprotein receptor family protein. A simi... | |||
TMPY-02748 | LRP-10 Protein, Human, Recombinant (His) | Human | HEK293 |
LRP10 (low-density lipoprotein Receptor Related Protein 10) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a low-density lipoprotein receptor family protein. A simi... | |||
TMPY-02196 | VAPB Protein, Human, Recombinant (His) | Human | E. coli |
Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein that belongs to the VAMP-associated ... | |||
TMPY-01675 | RAGE Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-05215 | TPP1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Tripeptidyl-peptidase 1 (TPP1 / CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activit... | |||
TMPY-01716 | RAGE Protein, Human, Recombinant (hFc) | Human | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-01847 | REG3D Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Regenerating islet-derived 3 delta (REG3D) is a member of the secreted Reg superfamily and contains one typical C-type lectin domain. Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encode... | |||
TMPY-05241 | SIRT5 Protein, Human, Recombinant (Flag) | Human | E. coli |
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul... | |||
TMPY-06954 | SIRT5 Protein, Human, Recombinant (His) | Human | E. coli |
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul... | |||
TMPY-02752 | SPG21 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of the AB hydrolase superfamily. Human SPG21 is a 38 amino acid residue protein widely expressed in all ... | |||
TMPY-01057 | SPG21 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of the AB hydrolase superfamily. Human SPG21 is a 38 amino acid residue protein widely expressed in all ... | |||
TMPY-02711 | Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant | Human | E. coli |
FTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin cha... | |||
TMPY-01693 | Butyrylcholinesterase Protein, Human, Recombinant (His) | Human | HEK293 |
Butyrylcholinesterase (BCHE), also known as cholinesterase or BuChE, is an enzyme defined as "pseudo" or "non-neuronal" cholinesterase. Butyrylcholinesterase (BCHE) is widely distributed in the nervous system as well as ... | |||
TMPY-06211 | Clusterin Protein, Chinese hamster, Recombinant (His) | Chinese hamster | CHO |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-03736 | REG1B Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreato... | |||
TMPY-01585 | SOD1 Protein, Human, Recombinant (His) | Human | E. coli |
SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmi... | |||
TMPH-02178 | TARDBP Protein, Human, Recombinant | Human | E. coli |
RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized withi... | |||
------------------------ More ------------------------ |
カタログ番号 | 製品名 | ||
---|---|---|---|
L2620 | Anti-Neurodegenerative Disease Compound Library | 2150 compounds | |
A unique collection of 2150 compounds related to neurodegenerative diseases can be used for HTS or HCS; | |||
L9000 | Apoptosis Compound Library | 1796 compounds | |
A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening; | |||
L2300 | Ion Channel Inhibitor Library | 946 compounds | |
A unique collection of 946 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery; | |||
L8700 | Ferroptosis Compound Library | 800 compounds | |
A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study; | |||
L8600 | Ubiquitination Compound Library | 214 compounds | |
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening; | |||
L7400 | Sodium Channel Blocker Library | 128 compounds | |
A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening; | |||
L2630 | Neuronal Differentiation Compound Library | 680 compounds | |
L9700 | Endoplasmic Reticulum Stress Compound Library | 193 compounds | |
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); | |||
L9830 | Anti-Parkinson's Disease Compound Library | 908 compounds | |
A unique collection of 908 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS. | |||
L9420 | Exosome Compound Library | 80 compounds | |
80 exosome-related compounds that can be used for high-throughput and high-content screening. | |||
L9840 | Anti-Alzheimer's Disease Compound Library | 1040 compounds | |
A unique collection of 1040 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS. |