Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
200 mg | 在庫あり | ¥ 7,500 | |||
500 mg | 在庫あり | ¥ 12,500 | |||
1 g | 在庫あり | ¥ 20,500 | |||
5 g | 在庫あり | ¥ 88,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
ターゲット&IC50 | SUR1:3 nM, SUR2A:5.4 nM, SUR2B:7.3 nM |
In vitro | Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity. |
In vivo | In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits. |
別名 | Glimperide, HOE-490 |
分子量 | 490.62 |
分子式 | C24H34N4O5S |
CAS No. | 93479-97-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (33.97 mM)
You can also refer to dose conversion for different animals. 詳細
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Glimepiride 93479-97-1 Membrane transporter/Ion channel Potassium Channel Inhibitor HOE490 HOE 490 Glimperide HOE-490 inhibit inhibitor