store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 14,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 50,000 | |||
25 mg | 在庫あり | ¥ 85,000 | |||
50 mg | 在庫あり | ¥ 125,000 | |||
100 mg | 在庫あり | ¥ 178,000 |
説明 | Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity. |
ターゲット&IC50 | H4 human glioblastoma:23.7 μM(IC50s), MAO-A:0.66 μM, DYRK1A:0.63 μM |
In vitro |
Harmalol (0.5-12.5 μM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.[1] Harmalol (25 μM) reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells.[2] |
別名 | Harmidol hydrochloride |
分子量 | 236.7 |
分子式 | C12H13ClN2O |
CAS No. | 6028-07-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (380.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Harmalol hydrochloride 6028-07-5 Metabolism oxidation-reduction Antioxidant P450 Harmidol hydrochloride Harmidol Hydrochloride Harmalol Hydrochloride Inhibitor inhibitor inhibit