Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 8,000 |
5 mg | 在庫あり | ¥ 16,500 |
10 mg | 在庫あり | ¥ 27,000 |
25 mg | 在庫あり | ¥ 52,500 |
50 mg | お問い合わせ | ¥ 89,000 |
100 mg | お問い合わせ | ¥ 130,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 24,500 |
説明 | Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism. |
In vitro | Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude. |
動物実験 | Adult Wistar rats were orally administered?Hypaconitine?(0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or?Hypaconitine?(2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot |
植物由来 |
分子量 | 615.71 |
分子式 | C33H45NO10 |
CAS No. | 6900-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (81.21 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Hypaconitine 6900-87-4 Apoptosis Metabolism TNF P450 Inhibitor TNFR TNF Receptor inhibit Tumor Necrosis Factor Receptor inhibitor