Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 7,500 | |||
2 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 15,500 | |||
10 mg | 在庫あり | ¥ 23,000 | |||
25 mg | 在庫あり | ¥ 45,000 | |||
50 mg | 在庫あり | ¥ 79,000 | |||
100 mg | 在庫あり | ¥ 142,000 | |||
500 mg | 在庫あり | ¥ 305,500 |
説明 | ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM). |
ターゲット&IC50 | PERK:5 nM |
In vitro | ISRIB blocks production of endogenous ATF4, whereas XBP1 mRNA splicing and XBP1s production persisted. ISRIB prevents cells from re-establishing ER homeostasis by blocking signaling through the PERK branch of the UPR, and decreases the viability of cells that are subjected to ER-stress. [1] |
In vivo | ISRIB shows favorable properties in pharmacokinetic profiling experiments and good bioavailability in vivo. ISRIB (0.25 mg/kg i.p.) increases long-term memory in mice by enhancing spatial and fear-associated learning. [1] |
細胞研究 | U2OS cells are plated on 96-well plates and left to recover overnight. Cells are treated with either with 2 μg/ml tunicamycin or 100 nM thapsigargin in the presence or absence of 100 nM ISRIB or with ISRIB alone for the indicated and the level of eIF2α phosphorylation is determined[1]. |
別名 | ISRIB, ISRIB trans-isomer, trans-isomer, trans-ISRIB |
分子量 | 451.34 |
分子式 | C22H24Cl2N2O4 |
CAS No. | 1597403-47-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.11 mg/mL (2.46 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ISRIB (trans-isomer) 1597403-47-8 Apoptosis Autophagy PERK ISRIB ISRIB (trans isomer) ISRIB (transisomer) ISRIB trans-isomer PKR-like endoplasmic reticulum kinase trans-isomer trans-ISRIB Inhibitor Protein kinase R-like endoplasmic reticulum kinase inhibit inhibitor