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カタログ番号 | 製品名 | 別名 | ターゲット |
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T10032 | COX-2-IN-2 | COX | |
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic acti... | |||
T10033 | COX-2-IN-1 | COX | |
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM). | |||
T77618 | COX-2-IN-34 | COX | |
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice. | |||
T62061 | COX-2-IN-6 | COX , Prostaglandin Receptor | |
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u... | |||
T7207 | FK 3311 | FK-3311,COX-2 Inhibitor V | COX |
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID) | |||
T0432 | Diclofenac diethylamine | Apoptosis , COX | |
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). | |||
T0458 | Indomethacin | Indocin,Indometacine,Indomethacine,Indometacin | Phospholipase , COX , PDE , Autophagy |
Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor. | |||
T0196 | Diclofenac | Diclofenacum,Voltaren | Apoptosis , COX |
Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a... | |||
T6737 | Zaltoprofen | CN100,Soleton | COX |
Zaltoprofen (Soleton) is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis. | |||
T1555 | Diclofenac sodium | GP 45840 | Apoptosis , COX |
Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. | |||
T6470 | Diclofenac Potassium | CGP-45840B,Cataflam,Voltfast | Apoptosis , Others , COX |
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. | |||
T0448 | (S)-(+)-Ibuprofen | Dexibuprofen,(S)-Ibuprofen | BCL , Thrombin , Cysteine Protease , COX , PPAR |
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX). | |||
T8356 | FPL 62064 | Lipoxygenase , COX | |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively). | |||
T22368 | Metyrosine | α-Methyltyrosine | COX |
Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressu... | |||
T7596 | Firocoxib | ML 1785713 | COX |
Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses. | |||
T7838 | Losartan Carboxaldehyde | COX | |
Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor. | |||
T1562 | Rebamipide | Proamipide,OPC12759 | Free radical scavengers , COX , Prostaglandin Receptor |
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ... | |||
T3214 | NS-398 | N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide,NS398 | COX |
NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity. | |||
T23333 | SC-58125 | SC 58125 | COX |
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic | |||
T50005 | Sertaconazole | Antifungal | |
Sertaconazole is a broad-spectrum antifungal. | |||
T79760 | COX-2-IN-35 | COX | |
COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1]. | |||
T62175 | COX-2-IN-8 | ||
COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib. | |||
T61264 | COX-2-IN-19 | ||
COX-2-IN-19 (Compound 24) is a highly potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 1.76 μM. Notably, COX-2-IN-19 exhibits robust in vivo anti-inflammatory activity [1]. | |||
T61714 | COX-2-IN-13 | ||
COX-2-IN-13 (compound 13e) is a highly potent and selective inhibitor of COX-2, demonstrating a remarkable IC50 value of 0.98 μM. It exhibits strong anti-inflammatory activity and has shown favorable results in vivo acut... | |||
T78706 | COX-2-IN-31 | COX | |
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This... | |||
T78705 | COX-2-IN-30 | COX | |
COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ... | |||
T63480 | COX-2-IN-26 | ||
COX-2-IN-26 is a potent, orally active, selective COX-2 inhibitor that acts on COX-1 (IC50: 10.61 μM), COX-2 (IC50: 0.067 μM), and 15-LOX (IC50: 1.96 μM).COX-2-IN-26 is anti-inflammatory and has a gastrointestinal safety... | |||
T63348 | COX-2-IN-23 | ||
COX-2-IN-23 is a selective inhibitor of COX-2, with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1, respectively.COX-2-IN-23 exhibits anti-inflammatory effects as well as low ulcerogenic effects. | |||
T61711 | COX-2-IN-14 | ||
COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory ac... | |||
T60978 | COX-2-IN-7 | ||
COX-2-IN-7 (compound 4a) is a potent, selective, and orally active COX-2 inhibitor which is higher selectivity than Celecoxib with an IC 50 value of 6.585 uM. COX-2-IN-7 has good anti-inflammatory and low ulcerogenic act... | |||
T61821 | COX-2-IN-16 | ||
COX-2-IN-16 (compound 2b) is a potent, selective, and orally active inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 102 μM. It effectively reduces nitric oxide (NO) production and demonstrates anti-inflammato... | |||
T78754 | COX-2-IN-33 | COX | |
COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent. It effectively suppresses pro-inflammatory cytokine production in vivo while ma... | |||
T79594 | COX-1/2-IN-5 | COX | |
COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and exhibits anticancer activity by inhibiting liver cancer HepG2... | |||
T4646 | TA-02 | p38 MAPK , Autophagy | |
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2. | |||
T64109 | COX-2-IN-28 | ||
COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM). | |||
T63943 | COX-2-IN-10 | ||
COX-2-IN-10 is a potent inhibitor of COX-2. COX-2-IN-10 exhibits inhibitory effects on the production of IL-6, TNF-α and IL-1β. COX-2-IN-10 inhibits PGE2 production in a concentration-dependent manner with an IC50 value ... | |||
T63646 | COX-2-IN-9 | ||
COX-2-IN-9 is a selective, potent, orally active COX-2 inhibitor (IC50: 10.17 μM).COX-2-IN-9 has a higher COX-2 selectivity than Celecoxib.COX-2-IN-9 exhibits good in vivo anti-inflammatory activity and low ulcerogenic e... | |||
T60457 | COX-2-IN-11 | ||
COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1]. | |||
T62259 | COX-2-IN-21 | ||
COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential. | |||
T63336 | COX-2-IN-29 | ||
COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM). | |||
T61760 | COX-2-IN-18 | ||
COX-2-IN-18 (Compound 3) is a highly effective COX-2 inhibitor with strong inhibitory activity against COX-2 (IC 50 = 0.775 μM). Its potency is comparable to the reference drug Celecoxib (IC 50 = 0.153 μM). This compound... | |||
T60566 | COX-2-IN-12 | ||
COX-2-IN-12 (compound 3b) is a potent and selective COX-2 inhibitor with an IC 50 of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent that shows safety in-vivo acute toxicity studies [1]. | |||
T64063 | COX-2-IN-24 | ||
COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects. | |||
T60464 | COX-2-IN-20 | ||
COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1]. | |||
T62142 | COX-2-IN-17 | ||
COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity. | |||
T79130 | COX-2-IN-32 | NF-κB | |
COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes NO production in LPS-induced RAW264.7 macrophages with an IC... | |||
T63215 | COX-2-IN-22 | ||
COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ... | |||
T60769 | COX-2/PI3K-IN-2 | ||
COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibitor of COX-2 (Ki = 3.02 nM) as well as a potent inhibitor of PI3K (IC 50 = 2.78 nM) [1]. | |||
T62241 | Topo I/COX-2-IN-2 | ||
Topo I/COX-2-IN-2 (Compound W10) is a potent dual Topo I (IC50: 0.90 μM) and COX-2 (IC50: 2.31 μM) inhibitor.Topo I/COX-2-IN-2 induces apoptosis in cancer cells using the mitochondrial pathway. | |||
T79360 | COX-2/15-LOX-IN-2 | Lipoxygenase | |
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX. Additionally, it exhibits significant antioxidant activity [1]. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T6S0413 | Pectolinarigenin | Pectolinaringenin | Others , Lipoxygenase , COX |
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
TN2139 | Regaloside B | NOS , COX , NO Synthase | |
Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2). | |||
T5758 | Sphondin | COX , Prostaglandin Receptor | |
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. | |||
T4643 | TFAP | N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide | COX , Endogenous Metabolite |
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor | |||
T0649 | Salicylic acid | 2-Hydroxybenzoic acid | Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy |
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase. | |||
T6S1572 | Sauchinone | ERK , p38 MAPK , NF-κB | |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... | |||
T1301 | Guaiacol | O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol | NF-κB , COX , Endogenous Metabolite |
Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator... | |||
TN3500 | Beta-Amyrone | β-Amyron | COX , AChR , PPAR , Antifection |
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a... | |||
T0399 | Methyl salicylate | Gaultheria oil,Methyl 2-hydroxybenzoate,2-Carbomethoxyphenol,Betula oil,Natural wintergreen oil,Wintergreen oil | COX , TRP/TRPV Channel |
Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic ... | |||
T3779 | Crocin II | Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B | Caspase , COX , NO Synthase |
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres... | |||
T0335 | Sodium salicylate | Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt | Apoptosis , NF-κB , COX , S6 Kinase , Autophagy |
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress. | |||
T5S2360 | Corydaline | Corydalin,(+)-Corydaline | P450 , Virus Protease , Opioid Receptor , AChE |
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr... | |||
T1633 | β-Carotene | Carotaben,Beta-Carotene,Provitamin A | Apoptosis , ROS , Endogenous Metabolite |
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene... | |||
T2826 | Asaraldehyde | Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde | COX |
Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1. | |||
T3883 | Roburic acid | COX | |
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2. | |||
T0065 | Acetaminophen | 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol | COX , Endogenous Metabolite , Histone Acetyltransferase |
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity. | |||
T2972 | Rutaecarpine | Rutacarpine,Rhetine,Rutecarpine | COX |
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM. | |||
TN1723 | Hamaudol | COX | |
Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 activities with values of 0.30, 0.57 mM, respectively. | |||
T3868 | Agnuside | chasteberry oil | COX , Prostaglandin Receptor , P-gp |
Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at conce... | |||
TN1377 | α-Spinasterol | alpha-Spinasterol | COX , Antibacterial , TRP/TRPV Channel |
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v... | |||
T2S1625 | (E)-Ethyl p-methoxycinnamate | Ethyl para-methoxycinnamate,Ethyl 4-methoxycinnamate,4-Methoxycinnamic Acid Ethyl Ester,Ethyl methoxycinnamate,Ethyl p-methoxycinnamate,EPMC | Others , COX |
1. (E)-Ethyl p-methoxycinnamate (EPMC) is an anticarcinogenic agent. 2. (E)-Ethyl p-methoxycinnamate (EPMC) is a glutathion S tranferase inhibitor. | |||
T4S0590 | Columbin | Phospholipase , COX , Parasite | |
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. | |||
T6S0722 | Isoorientin | Homoorientin,Luteolin-6-C-glucoside | Antioxidant , COX |
Isoorientin (Homoorientin) has antioxidant activity. | |||
T3747 | Syringaldehyde | Syringic aldehyde,Springaldehyde | COX |
syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity wi... | |||
TQ0288 | Hexahydrocurcumin | Reactive Oxygen Species , ROS , COX | |
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. | |||
T3342 | Xanthohumol | Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV | |
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ... | |||
T3039 | Hederagenin | Hederagenic acid,Astrantiagenin E,Caulosapogenin,Hederagenol | Others |
Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB. | |||
T5430 | [8]-Shogaol | 8-SHOGAOL | Apoptosis , COX |
[8]-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor. | |||
TN7025 | Canolol | Phenol, 4-ethenyl-2,6-dimethoxy- | COX |
Canolol (Phenol, 4-ethenyl-2,6-dimethoxy-) is an antioxidant phenolic compound that has potential use as a COX-2 inhibitor. | |||
T4S2126 | Ginkgetin | Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy | |
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ... | |||
T5759 | S-(+)-Marmesin | (+)-Marmesin,(S)-Marmesin,marmesin | Lipoxygenase , COX |
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity. | |||
T1468 | Lornoxicam | Ro 13-9297,Chlortenoxicam,TS110 | COX , Endogenous Metabolite |
Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam co... | |||
TC0036 | Compound Lup-20(29)-en-3-yl acetate | IL Receptor , VEGFR , Others , TNF , COX | |
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B. | |||
TN1373 | α-Humulene | Alpha-caryophyllene | TNF , NOS , COX |
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production an... | |||
T6S0077 | Byakangelicol | COX | |
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr... | |||
T3918 | Ginsenoside Rb3 | Gypenoside IV | NF-κB , COX , NO Synthase |
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA. | |||
T3811 | Ginsenoside C-K | Ginsenoside compound K,Ginsenoside K | P450 , cell cycle arrest , COX , NO Synthase |
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2. | |||
T6S1543 | Dehydrodiisoeugenol | Others , NF-κB , COX , Antibacterial | |
1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ... | |||
TQ0180 | Chebulagic acid | SARS-CoV , Influenza Virus , Lipoxygenase , COX | |
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor. | |||
T6S2023 | Harpagoside | Others , COX , NO Synthase | |
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression... | |||
T5431 | [10]-Shogaol | 10-Shogaol | Antioxidant , COX |
[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects. | |||
T5S1981 | Alpha-Cyperone | (+)-α-Cyperone,α-Cyperone | Others , Endogenous Metabolite |
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced... | |||
T25253 | Cinnamtannin B-1 | Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358 | Antioxidant , COX |
Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant a... | |||
T5727 | CAFESTOL | ERK , NF-κB , COX , PGE Synthase | |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... | |||
T4S1616 | Sanggenon D | Sanggenone D | NOS , COX , GABA Receptor |
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysa... | |||
TN1308 | 6-Hydroxyflavanone | Others , Lipoxygenase , COX , GABA Receptor | |
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r... | |||
T4A2456 | Gamabufotalin | Gamabufagin | COX |
1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect. | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01736 | COX-2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a perox... | |||
TMPJ-00704 | SCO1 Protein, Human, Recombinant (GST) | Human | E. coli |
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by hi... | |||
TMPY-00005 | FGF-8a Protein, Human, Recombinant | Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment... | |||
TMPY-00891 | Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) | Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2. | |||
TMPY-02792 | GDNF Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells |
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2. | |||
TMPY-02011 | CD96 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2. | |||
TMPY-00849 | ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2. | |||
TMPY-01691 | Clusterin Protein, Human, Recombinant (CLU34, His) | Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-00748 | Nectin-2 Protein, Human, Recombinant | Human | HEK293 Cells |
Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2. | |||
TMPY-00850 | ST2/IL-1 RL1 Protein, Human, Recombinant | Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2. | |||
TMPY-02358 | CD98 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD98 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P10852-2. | |||
TMPY-00871 | LAYN Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
LAYN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q6UX15-2. | |||
TMPY-04116 | KRAS Protein,Human,Recombinant(G12C & Q61H, His) | Human | E. coli |
KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-05288 | PLGF/PGF Protein, Human, Recombinant (aa 19-149) | Human | E. coli |
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2. | |||
TMPY-00341 | FGFR3 Protein, Human, Recombinant (alpha IIIb, His) | Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPJ-00850 | ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) | Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2. | |||
TMPY-01199 | CD74 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2. | |||
TMPY-01935 | C-Kit Protein, Human, Recombinant (His) | Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2. | |||
TMPY-00751 | TrkB Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2. | |||
TMPY-05586 | CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i... | |||
TMPY-04356 | GSK3B Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2. | |||
TMPY-02971 | CLEC10A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2. | |||
TMPY-04113 | KRAS Protein,Human,Recombinant(G12D & Q61H, His) | Human | E. coli |
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-01359 | ST2/IL-1 RL1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2. | |||
TMPY-04829 | G-CSF Protein, Human, Recombinant | Human | HEK293 Cells |
G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2. | |||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy... | |||
TMPY-01985 | CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2. | |||
TMPY-02096 | TACI Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2. | |||
TMPY-04844 | BTN3A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2. | |||
TMPY-02367 | Neuropilin-1 Protein, Human, Recombinant (isoform b, His) | Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2. | |||
TMPY-05427 | CD19 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2. | |||
TMPJ-00335 | TGFBR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2. | |||
TMPY-02820 | SDF-1 Protein, Human, Recombinant (isoform a) | Human | E. coli |
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2. | |||
TMPY-01871 | IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) | Human | HEK293 Cells |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2. | |||
TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d... | |||
TMPY-06056 | KRAS Protein, Human, Recombinant (G12D, His) | Human | E. coli |
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2. | |||
TMPY-03425 | Tau Protein, Human, Recombinant (His) | Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are... | |||
TMPY-02500 | YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2. | |||
TMPY-01888 | KRAS Protein,Human, Recombinant (Q61H, His) | Human | E. coli |
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2. | |||
TMPY-02432 | VEGF164 Protein, Rat, Recombinant | Rat | Baculovirus Insect Cells |
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2. | |||
TMPY-02231 | TrkB Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2. | |||
TMPY-05414 | NKG2D/CD314 Protein, Mouse, Recombinant (hFc) | Mouse | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2. | |||
TMPY-00747 | Nectin-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2. | |||
TMPY-00392 | PAM Protein, Human, Recombinant (His) | Human | HEK293 Cells |
PAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 94.4 kDa and the accession number is P19021-2. | |||
TMPY-01613 | Periostin/OSF-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2. | |||
TMPY-01717 | VEGF164 Protein, Mouse, Recombinant | Mouse | Baculovirus Insect Cells |
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2. | |||
TMPY-04644 | PDGFB Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit... | |||
TMPY-04051 | C-Kit Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2. | |||
TMPK-00709 | Tulp1 Protein, Human, Recombinant (His) | Human | E. coli |
The tubby-like protein 1 (tulp1) gene is a member of the tubby multigene family which includes tub, tulp1, tulp2 and tulp3.TULP1 is a cytoplasmic, membrane-associated protein shown to be involved in transportation of new... | |||
TMPY-02402 | WTAP Protein, Human, Recombinant (GST) | Human | E. coli |
Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identif... | |||
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