Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 52,500 | |||
25 mg | 在庫あり | ¥ 88,000 | |||
50 mg | 在庫あり | ¥ 130,500 | |||
100 mg | 在庫あり | ¥ 187,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 37,500 |
説明 | JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively). |
ターゲット&IC50 | EGFR:2.49 nM , p-EGFR VⅢ:4.48 nM , p-EGFR (WT):3.95 nM |
In vivo | Relative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model. |
分子量 | 376.18 |
分子式 | C16H11BrFN3O2 |
CAS No. | 2305154-31-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (26.58 mM)
You can also refer to dose conversion for different animals. 詳細
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JCN037 2305154-31-6 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Epidermal growth factor receptor HER1 Inhibitor inhibit JCN 037 JGK-037 ErbB-1 JGK037 JGK 037 JCN-037 inhibitor