Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 μM) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG.
説明 | JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 μM) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG. |
ターゲット&IC50 | FAAH (human):70 ± 8 nM, FAAH (rat):313 ± 28 nM |
別名 | JNJ42165279 |
分子量 | 410.8 |
分子式 | C18H17ClF2N4O3 |
CAS No. | 1346528-50-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (109.54 mM)
You can also refer to dose conversion for different animals. 詳細
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JNJ-42165279 1346528-50-4 Autophagy Metabolism Neuroscience FAAH Fatty acid amide hydrolase inhibit JNJ42165279 JNJ 42165279 Inhibitor inhibitor