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カタログ番号 | 製品名 | 別名 | ターゲット |
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T67745 | CB2R/FAAH modulator-2 | Cannabinoid Receptor , FAAH | |
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 10.8 and 152.9 nM for CB2R and CB1R, respectively, an... | |||
T11256 | FAAH inhibitor 1 | Benzothiazole analog 3 | FAAH |
FAAH inhibitor 1 (Benzothiazole analog 3) is an effective FAAH inhibitor with an IC50 of 18 nM. | |||
T67896 | CB2R/FAAH modulator-1 | Cannabinoid Receptor , FAAH | |
CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and i... | |||
T15268 | FAAH-IN-2 | O-Desmorpholinopropyl Gefitinib | FAAH , Autophagy |
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase). | |||
T67747 | CB2R/FAAH modulator-3 | Cannabinoid Receptor , FAAH | |
CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-3 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the ... | |||
T63536 | Dual FAAH/sEH-IN-1 | FAAH , Epoxide Hydrolase | |
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity. | |||
T6714 | URB-597 | KDS-4103,FAAH Inhibitor II | Mitophagy , FAAH , Autophagy |
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. | |||
T11255 | FAAH-IN-1 | FAAH | |
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively. | |||
T82421 | FAAH/cPLA2α-IN-1 | Phospholipase | |
FAAH/cPLA2α-IN-1 is a compound that simultaneously inhibits both FAAH and cPLA2α, demonstrating potent activity with half-maximal inhibitory concentrations (IC50s) of 32 nM for FAAH and 47 nM for cPLA2α [1]. | |||
T62558 | FAAH-IN-5 | ||
FAAH-IN-5 (Compound 7) is a relatively selective, irreversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50: 10.5 nM). FAAH-IN-5 has low PAMPA (parallel artificial membrane permeability assay) permeability. | |||
T73302 | FAAH-IN-7 | ||
FAAH-IN-7, a potent and reversible inhibitor of fatty acid amide hydrolase (FAAH), demonstrates significant neuroprotective effects, particularly by mitigating oxidative stress in 1321N1 astrocytes. With an IC50 value of... | |||
T62671 | FAAH/MAGL-IN-3 | ||
FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) that acts on FAAH (IC50: 179 nM) and MAGL (IC50: 759 nM). FAAH/MAGL-IN-3 showed littl... | |||
T61198 | FAAH/MAGL-IN-1 | ||
FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, res... | |||
T26311 | URB532 | URB-532,FAAH Inhibitor I,FAAH Inhibitor-I,URB 532 | |
URB532 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. | |||
T61707 | FAAH/MAGL-IN-2 | ||
FAAH/MAGL-IN-2, a potent and reversible inhibitor of FAAH and MAGL, demonstrates oral activity and the ability to cross the blood-brain barrier. It exhibits IC50 values of 11 nM for FAAH and 36 nM for MAGL (Ki values of ... | |||
T8927 | WWL 154 | WWL-154 | FAAH |
WWL 154 is an serine hydrolase (SH) and fatty acid amide hydrolase FAAH-4 inhibitor. | |||
T28353 | PDP-EA | FAAH | |
PDP-EA is an activator of fatty acid amide hydrolase(FAAH) and enhances the amidohydrolase activity of FAAH. | |||
T9967 | MAGL-IN-5 | Lipid | |
MAGL-IN-5 is a non-selective lipase inhibitor. | |||
T3215 | JNJ-42165279 | JNJ42165279 | FAAH , Autophagy |
JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 re... | |||
T8646 | URB937 | FAAH | |
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM). | |||
T7688 | 4-Nonylphenylboronic acid | FAAH | |
4-Nonylphenylboronic acid is a inhibitor of FAAH. | |||
T4323 | PF-04457845 | PF04457845,PF 04457845 | FAAH , Autophagy |
PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM). | |||
T2338 | JZL195 | FAAH , Lipase , Autophagy | |
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor. | |||
T15802 | LY2183240 | FAAH , Autophagy | |
LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM). | |||
T3354 | BIA 10-2474 | BIA10-2474 | FAAH , Autophagy |
BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest o... | |||
T1325 | Carprofen | Ridamyl,Imadyl,Rimadyl | FAAH , COX , Autophagy |
Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. | |||
T6043 | PF-3845 | FAAH , Autophagy | |
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2. | |||
T9687 | MAGL-IN-4 | His121 ARG57 | Lipase |
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases. | |||
T12306 | OMDM-5 | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel | |
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM). | |||
T2684 | JNJ-1661010 | JNJ1661010,Takeda-25,JNJ 1661010 | FAAH |
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2. | |||
T9374 | AA38-3 | 1-Piperidinecarboxylic acid, 4-nitrophenyl ester | FAAH , Lipase , MAGL |
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH) | |||
T12302 | OMDM-1 | (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide | Endogenous Metabolite |
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM. | |||
T16515 | PF 750 | PF-750,UNII-7756CPP14K,ZINC27647189 | FAAH |
PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times. | |||
T27703 | JZP-361 | JZP361,JZP 361 | Lipase |
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in ... | |||
T23119 | Palmitoylisopropylamide | FAAH | |
Palmitoylisopropylamide is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. | |||
T77594 | VU534 | FAAH , Phospholipase , Epoxide Hydrolase | |
VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism. | |||
T28076 | MM-433593 | FAAH | |
MM-433593 is a selective fatty acid amide hydrolase (FAAH-1) inhibitor for the treatment of pain, inflammation, and other disorders. | |||
T5357 | ARN272 | ARN 272 | FAAH |
ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM). | |||
T68492 | AM 374 | HDSF,Hexadecanesulfonyl fluoride | FAAH |
AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease resear... | |||
T6554 | JZL 184 | JZL184 | Lipase |
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively. | |||
T15635 | JZP-430 | Lipase , MAGL | |
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL... | |||
T4052 | KML29 | Lipase | |
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effective... | |||
T12826 | SA57 | FAAH | |
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH). | |||
T23432 | TC-F 2 | Others | |
TC-F 2 is a FAAH inhibitor. | |||
T12827 | SA72 | Others | |
SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH). | |||
T68407 | URB-694 | ||
URB-694 is a fatty acid amide hydrolase (FAAH) inhibitor. | |||
T33953 | PF3845yne | PF-3845yne,PF 3845yne | |
PF3845yne is an alkyne analogue of PF-3845 maintaining high potency for FAAH. | |||
T23415 | TAK 21d | Others | |
Potent FAAH inhibitor | |||
T29045 | UCM710 | ||
UCM710 is a dual inhibitor of α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH). | |||
T22582 | Arachidonyl serotonin | Others | |
Dual FAAH inhibitor/TRPV1 antagonist |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T2859 | Biochanin A | 4-Methylgenistein,Olmelin | EGFR , FAAH , Autophagy |
Biochanin A (4-Methylgenistein) is an isoflavone derivative isolated from red clover Trifolium pratense with anticarcinogenic properties. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor. | |||
TN1965 | N-Benzyllinolenamide | N-Benzyllinolenamide | FAAH , Autophagy |
N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM). | |||
T12139 | N-(3-Methoxybenzyl)Palmitamide | FAAH | |
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders. | |||
T3S2105 | N-Benzylpalmitamide | Macamide 1,N-Benzylhexadecanamide | Others , FAAH , Autophagy |
N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders... | |||
T4859 | 1-Monomyristin | rac-Glycerol 1-myristate,Glyceryl myristate,Monomyristin,2,3-Dihydroxypropyl tetradecanoate | Others , FAAH , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal |
1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial strains. 1-Myristoyl-rac-glycerol is used in colloidal chemistr... | |||
TMA1122 | N-Feruloylserotonin | (E/Z)-Moschamine,Moschamine | Antioxidant |
N-Feruloylserotonin ((E/Z)-Moschamine) is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01325 | FAAH2 Protein, Human, Recombinant (His) | Human | E. coli |
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatt... |
カタログ番号 | 製品名 | ||
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L2510 | Lipid Metabolism Compound Library | 492 compounds | |
A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). |