Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
説明 | LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity. |
In vitro | Five cell lines that express CES2 responded to LY2334737treatment. LY2334737 was less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. The drug response of CES2-transfected HCT-116 cells correlated with CES2 expression level. Bystander studies showed statistically greater PC-3-GFP growth inhibition by LY2334737 when cells were cocultured with CES2 and not mock transfectants [1]. |
In vivo | Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days showed greater tumor growth inhibition of CES2 transfectant than the mock transfectant (P ≤ 0.001) [1]. The MTD was 40 mg LY2334737. Fatigue was the most frequent DLT for LY2334737monotherapy (4 patients) followed by elevated transaminase levels (2 patients), both observed at the 40- to 50-mg dose levels. Among the 10 patients in the combination arm, 2 had DLTs at the 40-mg dose level. These were fatigue and elevated liver enzyme levels [2]. Metronomic LY2334737 administration caused increased blood flow in luciferase-tagged LM2-4 tumor xenografts, and this effect, readily measured using contrast micro-ultrasound, coincided with a relative increase in tumor bioluminescence [3]. |
分子量 | 389.39 |
分子式 | C17H25F2N3O5 |
CAS No. | 892128-60-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (115.56 mM)
You can also refer to dose conversion for different animals. 詳細
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LY2334737 892128-60-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others Nucleoside Antimetabolite/Analog Virus Protease anticancer LY-2334737 HEV Gemcitabine HEVs HRVs EV-A71 Rhinovirus inhibit LY 2334737 Enterovirus HRV orally antiviral Inhibitor inhibitor