Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
説明 | Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. |
別名 | ML246 |
分子量 | 474.6 |
分子式 | C31H30N4O |
CAS No. | 1443414-10-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (65.84 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Metarrestin 1443414-10-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis breast ML 246 perinucleolar HeLa ML246 nucleolar Inhibitor PANC1 orally metastatic transcription inhibit eEF1A2 PC3M compartment pancreatic ML-246 inhibitor