Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.
説明 | 1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. |
ターゲット&IC50 | IL-1β:10.8 nM (IC50), TNF-α:16.4 nM (IC50) |
植物由来 |
別名 | 7-O-Methylbaicalein, Baicalein-7-methylether |
分子量 | 284.26 |
分子式 | C16H12O5 |
CAS No. | 29550-13-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
DMSO: 50 mg/mL (175.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Negletein 29550-13-8 Apoptosis Immunology/Inflammation IL Receptor TNF NOS Interleukin inhibit TNF Receptor Interleukin Related TNFR outgrowth neuroprotectant Tumor Necrosis Factor Receptor Inhibitor growth,factor anti-inflammatory cell 7-O-Methylbaicalein nerve Baicalein-7-methylether PC12 neurite inhibitor