| TN1124 |
Neoeriocitrin
|
|
AChE
|
|
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor. |
| T2S0731 |
Trilobatin
|
P-Phlorizin |
Amylase
|
|
Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon... |
| T2S0843 |
Negletein
|
7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor
,
TNF
,
NOS
,
Interleukin
|
|
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n... |
| TN6924 |
Anhydrosafflor yellow B
|
(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB |
Others
|
|
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... |
| T2S0531 |
Pinoresinol dimethyl ether
|
(+)-Eudesmin |
Others
,
PKC
|
|
Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity. It stimulates upstream MAPK, PKC, and PKA pathways, inducing neurite outgrowth in PC12 cells. |
| TN6982 |
Diethyl phthalate
|
1,2-diethyl benzene-1,2-dicarboxylate |
Apoptosis
|
|
Diethyl phthalate (1,2-diethyl benzene-1,2-dicarboxylate) is a endocrine disrupter affecting the apoptotic system in PC12 cells. Diethyl phthalate is widely used in many plastics and personal care products. |
| T5S2195 |
Sibiricose A5
|
|
Dehydrogenase
|
|
Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia. |
| T19882 |
Bryonolic acid
|
UNII-J7YR6A878I,20-epi-Bryonolic acid |
Apoptosis
,
Antioxidant
,
Calcium Channel
|
|
Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apo... |
| TN1911 |
Marein
|
|
transporter
,
Akt
,
HDAC
,
AMPK
|
|
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... |
| TN7108 |
Urolithin C
|
|
Apoptosis
,
Calcium Channel
,
Reactive Oxygen Species
,
IGF-1R
,
Endogenous Metabolite
|
|
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. |
| TN2082 |
Pinostrobin
|
|
Beta Amyloid
,
IL Receptor
,
Serine/threonin kinase
,
TNF
|
|
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress... |
| T3836 |
Eudesmin
|
|
MAPK
,
S6 Kinase
|
|
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m... |
| T2854 |
Phillyrin
|
Forsythin |
P450
,
Influenza Virus
,
AMPK
|
|
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ... |
| T2823 |
Crocin
|
Gardenia Yellow,Alpha-Crocin |
Others
|
|
Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne... |
| T37280 |
PE(18:1(9Z)/0:0)
|
|
Endogenous Metabolite
|
|
PE(18:1(9Z)/0:0) is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. PE(18:1(9Z)/0:0) induces transient increases in intracellular calcium in PC12 rat neuronal cells in a ... |
| T4956 |
Tetrahydroxystilbene-2-O-β-D-glucoside
|
tetrahydroxyl diphenylethylene-2-o-gluco,EH-201 |
Others
|
|
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc... |
| T2230 |
Paeoniflorin
|
Peoniflorin |
HSP
,
COX
|
|
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. |
| T3826 |
Polygalasaponin F
|
|
NF-κB
,
TLR
,
Akt
,
PI3K
|
|
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... |
| TN4127 |
Gentiside J
|
|
Others
|
|
Gentiside J is a potent inducer of neurite outgrowth on PC12 cells. |
| T29462 |
5-OH-HxMF
|
|
|
|
5-OH-HxMF is an inducer of neurite growth in PC12 cells through the camp / PKA / CREB pathway. |
| T81213 |
Sarbronine M
|
|
|
|
Scabronine M, a novel inhibitor, impedes NGF-induced neurite outgrowth from PC12 cells. |
| TN4126 |
Gentiside B
|
|
Others
|
|
Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) conc... |
| TN1726 |
Heishuixiecaoline A
|
|
Others
|
|
Heishuixiecaoline A protects against neurotoxicity in PC12 cells. |
| T82444 |
Erinacine U
|
|
|
|
Erinacine U, a cyanogen diterpene extracted from Hericium erinaceus, exhibits neurotrophic properties and significantly enhances neurite outgrowth in PC12 cells [1]. |
| TMA2419 |
Catalponol
|
|
cAMP
|
|
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP. |
| T83268 |
6-Epiagarotetrol
|
|
|
|
6-Epiagarotetrol, a neuroprotective agent derived from Aquilaria sinensis, exhibits protective effects against corticosterone-induced damage in PC12 cells [1]. |
| TN4935 |
Salvianolic acid Y
|
|
Others
|
|
Salvianolic acid Y, isolated from Salvia officinalis, is a protector of PC12 cells against hydrogen peroxide-induced injury from Salvia officinalis. |
| T37957 |
Setosusin
|
|
|
|
Setosusin is a meroterpenoid fungal metabolite originally isolated from C. setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tre... |
| TN4651 |
Neuchromenin
|
|
Others
|
|
(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml. |
| TN3618 |
Cedrin
|
|
Beta Amyloid
,
BCL
,
Caspase
|
|
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppres... |
| T82042 |
Isoasiaticoside
|
|
|
|
Isoasiaticoside, a pentacyclic triterpene saponin derived from Centella asiatica, exhibits potential neuroprotective effects in the 6-OHDA-induced PC12 cell model [1]. |
| T81676 |
NG-012
|
|
|
|
NG-012, a nerve growth factor (NGF) potentiator, was isolated from the culture broth of Penicillium verruculosum F-4542. It enhances neurite outgrowth as induced by NGF in the rat pheochromocytoma cell line (PC12) [1]. |
| T81524 |
Peimisine 3-O-β-D-glucopyranoside
|
|
|
|
Peimisine 3-O-β-D-glucopyranoside (Compound 1), a steroid alkaloid, is isolated and purified from Fritillaria unibracteata and demonstrates a moderate protective effect against rotenone-induced neurotoxicity in the PC12 ... |
| TN2844 |
(2R,3S)-Dihydrodehydroconiferyl alcohol
|
|
MAPK
,
PKC
|
|
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC. |
| TN6469 |
Biatractylolide
|
|
|
|
Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatra... |
| TMA0984 |
Cerevisterol
|
|
DNA/RNA Synthesis
|
|
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. |
| TN6515 |
Selaginellin
|
|
|
|
Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression ... |
| TN2626 |
14-Norpseurotin A
|
|
Antifection
|
|
14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs ... |
| TN3607 |
Catalpalactone
|
|
cAMP
|
|
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone c... |
