Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
説明 | Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway. |
分子量 | 510.61 |
分子式 | C26H30N4O5S |
CAS No. | 1613220-15-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 1 mg/mL, Sonication is recommended.
DMSO: 70 mg/mL (142.11 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Niraparib tosylate monohyrate 1613220-15-7 Chromatin/Epigenetic DNA Damage/DNA Repair PARP Niraparib tosylate Apoptosis cancer MK-4827 tosylate inhibit breast lung poly ADP ribose polymerase anti-tumor orally DNA damage Inhibitor bioavailable ovarian inhibitor