Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 35,000 | |||
5 mg | 在庫あり | ¥ 86,000 | |||
10 mg | 在庫あり | ¥ 128,000 | |||
25 mg | 在庫あり | ¥ 206,000 | |||
50 mg | 在庫あり | ¥ 280,000 | |||
100 mg | 在庫あり | ¥ 379,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 126,500 |
説明 | Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. |
ターゲット&IC50 | PPARγ:153.5 μM (IC50), PPARβ:102.4 μM (IC50), PPARα:92.8 μM (IC50) |
In vitro | Normal or IR L6 myotubes were incubated with Norathyriol (2.5 - 10 μM, 0.625 - 2.5 μM), mangiferin (10 - 40 μM, 2.5 - 10 μM) or rosiglitazone (20 μM) and/or 0.05 nM insulin for 24 h, respectively. The glucose consumption was assessed using the glucose oxidase method. Immunoblotting was performed to detect protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK) phosphorylation in L6 myotubes cells. Norathyriol and mangiferin treatment alone increased the glucose consumption 61.9 and 56.3%, respectively, in L6 myotubes and made additional increasing with 0.05 nM insulin. In IR L6 myotubes, Norathyriol treatment made increasing with or without insulin, mangiferin treatment also made increasing but only when co-treated with insulin. Immunoblotting results showed that Norathyriol and mangiferin produced an increase of 1.9 - and 1.8-fold in the phosphorylation levels of the AMPK, but not in Akt[1] |
植物由来 |
分子量 | 260.2 |
分子式 | C13H8O6 |
CAS No. | 3542-72-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (249.81 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Norathyriol 3542-72-1 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism PI3K/Akt/mTOR signaling PPAR AMPK DNA/RNA Synthesis Akt anti-bacterial Mangiferitin metabolite Mangifera anticancer Natural Antioxidant Glucosidase Inhibitor anti-inflammatory Peroxisome proliferator-activated receptors antimicrobial α-glucosidase inhibit inhibitor