keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 63,500 | |||
25 mg | 在庫あり | ¥ 121,000 | |||
50 mg | 在庫あり | ¥ 175,000 | |||
100 mg | 在庫あり | ¥ 245,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,500 |
説明 | Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways. |
In vitro | Porinic acid (PA) exerted antitumor effects on NCI-H23 and NCI-H460 lung cancer cells in vitro, while inducing cellular G2/M phase arrest and apoptosis. Our data showed that PA induced reactive oxygen species (ROS) production, leading to activation of c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells. Furthermore, blocking ROS production reversed PA-induced JNK and ER stress activation. Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any toxicity to the host, and suppressed cell proliferation and induced apoptosis in tumor xenograft tissues [1]. At the same time, PA induced cell cycle arrest at G0 phase.PA also significantly inhibited cancer cell migration and invasion in a dose-dependent manner. Interestingly, PA inhibited the adhesion ability of cancer cells in a dose-dependent manner, which may contribute to the inhibition of cell invasion. Finally, it was shown that PA inhibited AKT and ERK signaling pathways. And tumor proteins such as PCNA, ICAM-1 and RhoA, which are involved in tumorigenesis, were also down-regulated by PA [1]. |
細胞研究 | The anti-proliferative ability of PA on lung cancer cells was assessed by MTT, colony formation and EdU proliferation assays; cell cycle changes were detected by flow cytometry; apoptosis was detected by annexin V/PI double staining and DNA laddering; and the expression of apoptosis-related proteins was analyzed by Western blotting [1]. |
植物由来 |
別名 | 3-O-Acetyltumulosic acid |
分子量 | 528.76 |
分子式 | C33H52O5 |
CAS No. | 29070-92-6 |
keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7 mg/mL (13.24 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Pachymic acid 29070-92-6 Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Akt ERK PKB Protein kinase B inhibit Extracellular signal regulated kinases Inhibitor 3-O-Acetyltumulosic acid inhibitor