検索結果

Search Results for " LDL "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T10063	LDL-IN-3		Antioxidant
	LDL-IN-3 shows anti-atherosclerotic and antioxidant activities.		Antioxidant
T4039	BIBB 515		Others
	BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of...		Others
T7832	Ibrolipim	NO-1886	LPL Receptor
	Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.		LPL Receptor
T2626	SBC-115076	SBC115076	Others , Serine/threonin kinase
	SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.		Others , Serine/threonin kinase
T9276	SBC-115337		Others , Serine/threonin kinase
	SBC-115337 is a PCSK9 inhibitor.		Others , Serine/threonin kinase
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T6690	T0901317		Apoptosis , FXR , Liver X Receptor , ROR
	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).		Apoptosis , FXR , Liver X Receptor , ROR
T1928	Anacetrapib	MK-0859	CETP
	Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th...		CETP
T4179	Probucol disuccinate		LDL
	Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.		LDL
T4058	R-IMPP		Others , Serine/threonin kinase
	R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.		Others , Serine/threonin kinase
TP1881L1	Pep 2-8 ammonium salt(1541011-97-5 free base)		Others
	Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.		Others
T3625	Bempedoic acid	ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase , AMPK
	Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ...		ATP Citrate Lyase , AMPK
T67776	PCSK9-IN-11		Others
	PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l...		Others
T9916	Alirocumab		Others
	Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.		Others
T20887	Atorvastatin Sodium	Lipitor	LDL , Aquaporin , HMG-CoA Reductase
	Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ...		LDL , Aquaporin , HMG-CoA Reductase
T27832	Lifibrol	U 83860,K-12148,K-12.148,U-83860,K12148	Lipid
	Lifibrol (U-83860) is an inhibitor of cholesterol synthesis.Lifibrol has anticholesterol and hypolipidemic properties and promotes the conversion of LDL Apo B-100 in patients with hypercholesterolemia and mixed hyperlipi...		Lipid
T1771	Ro 48-8071 fumarate		Others
	Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.		Others
T68042	CHF-4227	Chf4227,Chf 4227	Estrogen Receptor/ERR
	CHF-4227 is a novel, potent and selective estrogen receptor modulator that reduces cholesterol and LDL cholesterol concentrations.		Estrogen Receptor/ERR
T76739	Bococizumab	RN316,PF-04950615	Others
	Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to...		Others
T0342	Carvedilol phosphate hemihydrate	Carvedilol phosphate,BM 14190 (phosphate hemihydrate)	VEGFR , Others , Potassium Channel , LDL , Integrin , Gap Junction Protein , NADPH , Adrenergic Receptor , Autophagy
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom...
T38063	N-Acetyl lysyltyrosylcysteine amide		Glutathione Peroxidase
	N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Ac...		Glutathione Peroxidase
T5360	Eprotirome	KB2115	Thyroid hormone receptor(THR)
	Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.		Thyroid hormone receptor(THR)
TP1111	Tirzepatide	LY-3298176	Glucagon Receptor
	Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor with neuroprotective activity for the study of diabetes and obesity.		Glucagon Receptor
TP1881	Pep2-8	Pep 2-8
	Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
T70504	6,8-Diprenyleriodictyol
	6,8-Diprenyleriodictyol is an antioxidant, which inhibits Cu(2+)-mediated oxidation of human low density lipoprotein (LDL).
T76377	Cdk2/Cyclin Inhibitory Peptide II
	Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, demonstrates dose-dependent cytotoxic effects on U2OS osteosarcoma cells [1].
T77144	Recaticimab
	Recaticimab (SHR-1209) is a humanized monoclonal antibody targeting PCSK9 to enhance the degradation of this enzyme. By binding to PCSK9, Recaticimab elevates low-density lipoprotein (LDL) receptor presence on hepatocyte...
T30111	AR 12465	AR-12465
	AR 12465 is a trapidil derivative which may affect LDL receptor mediated uptake and degradation of 125 I-LDL by human skin fibroblasts (HSF) and human hepatic cells (HEP G2).
T74778	ASM-IN-1		Phospholipase
	ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic ar...		Phospholipase
T11386	Gemcabene calcium	PD-72953 calcium	Others
			Others
T73008	PCSK9-IN-13
	PCSK9-IN-13 is a potent inhibitor of PCSK9, effectively preventing the binding of PCSK9 to low-density lipoprotein (LDL) receptors through its mechanism of action. It exhibits this inhibitory activity with an IC 50 value...
T35404	(±)13-HODE cholesteryl ester
	(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human mono...
T35405	(±)9-HODE cholesteryl ester
	(±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monoc...
T76974	Tafolecimab
	Tafolecimab (IBI-306), a human IgG2 monoclonal antibody, specifically targets and binds to PCSK-9, thus inhibiting PCSK-9-mediated endocytosis of the LDL receptor. This action enhances the clearance of LDL-C, resulting i...
T68695	(R)-Bambuterol
	Bambuterol is a prodrug of β2-agonist commonly used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) with the advantage of once daily dosing and favorable side effect profile. Administration o...
T15561	Imanixil	HOE-402(free base)	Others
	Imanixil is an inducer of the LDL receptor (LDLR) and it is also a potent cholesterol-lowering compound. It also inhibits very low density-lipoprotein (VLDL) production and consequently decreases atherosclerosis developm...		Others
T79239	PCSK9-IN-19
	PCSK9-IN-19 (Compound 1), a PCSK9 inhibitor, is utilized in researching the treatment of high LDL-cholesterol levels and the prevention of coronary artery disease [1].
T75537	N-Acetyldopamine dimer-2
	N-Acetyldopamine dimer-2 (compound 2), an N-acetyldopamine dimer derived from the yellow powder of Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties. It notably inhibits oxidation of oxidized lo...
T80658	Quercetin 7-glucuronide	Quercetin 7-O-β-glucuronide	Drug Metabolite
	Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a Quercetin metabolite found in Madagascarian Uncarina species, has the capability to inhibit LDL oxidation [1].		Drug Metabolite
T36727	9(S)-HODE
	9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.[1],[2] It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL pa...
T69408	GW590735 sodium
	GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased...
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ...
T28080	Mocravimod	KRP 203 free base,KRP-203,KRP203
	Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged gr...
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (...
T36171	KDdiA-PC
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as ...
T75778	COG 133 TFA
	COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a ...
T60541	PCSK9 modulator-2
	PCSK9 modulator-2 (Compound 1) is a potent PCSK9 modulator (EC 50 = 202 nM) that has the potential to be used in hyperlipidemia research. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently validated ther...
T38908	MK-8262
	MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (...
T38063L	N-Acetyl lysyltyrosylcysteine amide acetate	N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)	Glutathione Peroxidase
	N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) genera...		Glutathione Peroxidase
T77014	Frovocimab
	Frovocimab (LY 3015014), a humanized IgG4 monoclonal antibody (mAb), acts by neutralizing PCSK9. This mechanism effectively prevents PCSK9 from binding to the LDL receptor (LDLR) while allowing for the normal proteolytic...

Compounds

Target: Others, Serine/threonin kinase

SBC-115337

T9276

Synonym:

Target: Others, Serine/threonin kinase

Target: Apoptosis, FXR, Liver X Receptor, ROR

Target: Others, Serine/threonin kinase

Pep 2-8 ammonium salt(1541011-97-5 free base)

Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002

Target: ATP Citrate Lyase, AMPK

Target: LDL, Aquaporin, HMG-CoA Reductase

Lifibrol

T27832

Synonym: U 83860,K-12148,K-12.148,U-83860,K12148

Synonym: Chf4227,Chf 4227

Target: Estrogen Receptor/ERR

Bococizumab

T76739

Synonym: RN316,PF-04950615

Target: Others

Carvedilol phosphate hemihydrate

T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate)

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

N-Acetyl lysyltyrosylcysteine amide

T38063

Synonym:

Target: Glutathione Peroxidase

Eprotirome

T5360

Synonym: KB2115

Target: Thyroid hormone receptor(THR)

Tirzepatide

TP1111

Synonym: LY-3298176

Target: Glucagon Receptor

6,8-Diprenyleriodictyol

T70504

Synonym:

Target:

Cdk2/Cyclin Inhibitory Peptide II

Target: Phospholipase

Gemcabene calcium

T11386

Synonym: PD-72953 calcium

(±)13-HODE cholesteryl ester

T35404

Synonym:

Target:

(±)9-HODE cholesteryl ester

Synonym: HOE-402(free base)

N-Acetyldopamine dimer-2

T75537

Synonym:

Target:

Quercetin 7-glucuronide

T80658

Synonym: Quercetin 7-O-β-glucuronide

Target: Drug Metabolite

Synonym: KRP 203 free base,KRP-203,KRP203

N-Acetyl lysyltyrosylcysteine amide acetate

T38063L

Synonym: N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)

Target: Glutathione Peroxidase

カタログ番号	製品名	別名	ターゲット
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
TN1438	Beta-Amyrin acetate		Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
T5214	Cholesteryl linoleate	CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester	Others , Endogenous Metabolite
	Cholesteryl linoleate (Linoleic Acid cholesteryl ester) is a cholesterol ester found in LDL. Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via...		Others , Endogenous Metabolite
T0254	Probucol	DH-581	Virus Protease , ABC , Lipid
	Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.		Virus Protease , ABC , Lipid
T6S1930	Schisanhenol	Schizanhenol,Gomisin-K3	Antioxidant
	1. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanheno...		Antioxidant
TN1511	Cleomiscosin A		LDL , Antioxidant , TNF
	Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin A can be used in studies about the prevention of LDL oxidat...		LDL , Antioxidant , TNF
TWO2727	Propane-1,2,3-triyl tripalmitate	Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate	Others , Endogenous Metabolite
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) is a triacylglycerol found in dietary fats. Tripalmitin increases body weight and plasma LDL levels and reduces hepatic LDL receptor mRNA levels in hamsters fed a ...		Others , Endogenous Metabolite
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
TN2967	Pinobanksin 3-acetate	3-O-Acetylpinobanksin	Others , Antioxidant
	Pinobanksin 3-acetate (3-O-Acetylpinobanksin), a flavonoid derivative, is a strong antioxidant found in sunflowers and honey that inhibits LDL peroxidation.		Others , Antioxidant
T3771	Methyl protodioscin	Smilax saponin B,NSC-698790	Apoptosis
	Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...		Apoptosis
T4S2157	Campesterol	(24R)-5-Ergosten-3β-ol	Endogenous Metabolite
	Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory e...		Endogenous Metabolite
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T5S1172	Tiliroside	Tribuloside	Antioxidant
	1. Tiliroside (Tribuloside) shows anticarcinogenic activity. 2. Tiliroside shows hepatoprotective activity. 3. Tiliroside shows antioxidant and anti-inflammatory activity, can inhibit neuroinflammation in neurodegenerati...		Antioxidant
T2938	(E/Z)-Polydatin	Polydatin,(E/Z)-Piceid	Phospholipase
	(E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be det...		Phospholipase
TN1338	7Beta-Hydroxycholesterol		LDL , Calcium Channel , MAPK
	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.		LDL , Calcium Channel , MAPK
TN4956	Scandoside		NF-κB , MAPK
	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation.		NF-κB , MAPK
TN5057	Stachybotramide		LDL
	Stachybotramide preferentially stimulate the plasma cholesteryl ester transfer protein (CETP)-mediated transfer of cholesteryl esters (CE) from high density lipoprotein (HDL) to both very low density lipoprotein (VLDL) a...		LDL
TN3675	Cleomiscosin C		LDL
	Cleomiscosin C has antioxidant activity, it protects against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl ( IC50s of 23.6 and 3.9 microM, respectively), suggests that it could be beneficial in pr...		LDL
T36560	(±)9-HpODE
	(±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid. It shows antimicrobial activity against various fungal and bacterial pathogens and th...
T83915	Norbixin hydrate
	Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of ...
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin...

天然物製品

Target: Antioxidant, HMG-CoA Reductase, Epoxide Hydrolase, Antifungal

Cholesteryl linoleate

T5214

Synonym: CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester

Target: Others, Endogenous Metabolite

Probucol

T0254

Synonym: DH-581

Target: Virus Protease, ABC, Lipid

Schisanhenol

T6S1930

Synonym: Schizanhenol,Gomisin-K3

Target: LDL, Antioxidant, TNF

Propane-1,2,3-triyl tripalmitate

TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate

Target: Others, Endogenous Metabolite

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Pinobanksin 3-acetate

TN2967

Synonym: 3-O-Acetylpinobanksin

Target: Others, Antioxidant

Methyl protodioscin

T3771

Synonym: Smilax saponin B,NSC-698790

Target: Apoptosis

Campesterol

T4S2157

Synonym: (24R)-5-Ergosten-3β-ol

Target: Endogenous Metabolite

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

Polydatin

T3427

Synonym: Piceid,Polydotin Peceid

Target: Apoptosis, Mitophagy, NF-κB, Autophagy

Synonym: Polydatin,(E/Z)-Piceid

Target: Phospholipase

7Beta-Hydroxycholesterol

TN1338

Synonym:

Target: LDL, Calcium Channel, MAPK

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00989	LDLR Protein, Human, Recombinant (His)	Human	HEK293
	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPK-01297	LDLR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embe...
TMPK-00402	LDLR Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embe...
TMPY-05499	LDLR Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05323	LDLR Protein, Human, Recombinant (mFc)	Human	HEK293
	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05809	LDLR Protein, Human, Recombinant (193D/A, His)	Human	HEK293
	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPJ-00394	LDLR Protein, Human, Recombinant (Avi & His), Biotinylated	Human	Human Cells
	Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repe...
TMPY-06834	LRP-6 Protein, Human, Recombinant (hFc)	Human	HEK293
	Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipo...
TMPY-06698	LRP-6 Protein, Human, Recombinant (His)	Human	HEK293
	Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipo...
TMPY-01881	Lp-PLA2/PLA2G7 Protein, Human, Recombinant (His)	Human	HEK293
	Platelet-activating factor acetylhydrolase, also known as 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycero-phosphocholine esterase, Group-VIIA phospholipase A2, LDL-associated phospholipase A2, PAF...
TMPJ-00553	Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His)	Human	Human Cells
	Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive...
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion...
TMPY-06639	LRP-5 Protein, Human, Recombinant (His)	Human	HEK293
	LRP-5 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 71.21 kDa. Accession number: O75197-1
TMPJ-01319	TINAGL1 Protein, Human, Recombinant (His)	Human	Human Cells
	TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so ...
TMPY-01085	VLDLR Protein, Human, Recombinant (His)	Human	HEK293
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and A...
TMPY-01014	LDLR Protein, Mouse, Recombinant (His)	Mouse	HEK293
	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05348	LDLR Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPK-01505	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KD...
TMPK-01504	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KD...
TMPK-01506	HLA-A*02:01&B2M&HPV16 E7 (YMLDLQPET) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	HPV16 E7 protein, one of the primary target proteins in molecular targeted therapy for HPV-induced cervical cancer. The affitoxin, ZHPV16E7 affitoxin384 was generated by fusing the modified Pseudomonas Exotoxin A (PE38KD...
TMPK-00928	VLDLR Protein, Mouse, Recombinant (His)	Mouse	HEK293
	VLDLR cerebellar hypoplasia (VLDLR-CH) is characterized by non-progressive congenital ataxia that is predominantly truncal and results in delayed ambulation, moderate-to-profound intellectual disability, dysarthria, stra...
TMPY-00383	LDLRAD3 Protein, Human, Recombinant (hFc)	Human	HEK293
	LDLRAD3 Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 43.8 kDa. Accession number: Q86YD5-1
TMPY-04310	Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His)	Human	HEK293
	Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1...
TMPY-01081	SR-BI/SCARB1 Protein, Human, Recombinant (His)	Human	HEK293
	Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localiz...
TMPY-01062	EGF Protein, Human, Recombinant (hFc)	Human	HEK293
	EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ...
TMPY-06984	EGF Protein, Mouse, Recombinant (Yeast)	Mouse	Yeast
	EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ...
TMPY-01560	EGF Protein, Human, Recombinant	Human	E. coli
	EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. ...
TMPY-05337	CXCL16 Protein, Human, Recombinant (His)	Human	HEK293
	C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 exists in transmemb...
TMPH-02515	APOC1 Protein, Mouse, Recombinant (His)	Mouse	in vitro E. coli expression system
	Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the tria...
TMPJ-00805	Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and ca...
TMPJ-01447	Apolipoprotein B-100/APOB Protein, Human, Recombinant (His)	Human	E. coli
	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles ...
TMPH-02502	LRPAP1 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
TMPY-03371	LOX-1 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-liga...
TMPY-04066	LOX-1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-liga...
TMPY-02490	LOX-1 Protein, Human, Recombinant (His)	Human	HEK293
	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-liga...
TMPJ-00014	Resistin Protein, Human, Recombinant (His)	Human	E. coli
	Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into ...
TMPY-03351	LOX-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-liga...
TMPH-01612	LSR Protein, Human, Recombinant (His)	Human	E. coli
	Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.
TMPK-01063	LRP-10 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	LDL receptor-related protein (LRP) 10 was recently identified as a Parkinson's disease gene through genome-wide linkage and sequencing analysis, but its role in Parkinson's disease in various populations is still unclear...
TMPY-03950	CD204/MSR1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contain...
TMPY-00927	CD204/MSR1 Protein, Human, Recombinant (His)	Human	HEK293
	Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contain...
TMPY-02128	Serpin B1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Serum SerpinB1 levels are elevated in patients with type 2 diabetes compared with that in healt...
TMPK-00483	PCSK9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injec...
TMPJ-00756	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)	Human	Human Cells
	ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipo...
TMPY-03168	CD204/MSR1 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contain...
TMPY-00528	CD204/MSR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contain...
TMPJ-01412	LRP-12 Protein, Human, Recombinant (His)	Human	Human Cells
	Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 c...
TMPJ-01345	TCblR Protein, Human, Recombinant (His)	Human	Human Cells
	CD320 antigen is also known as 8D6 antigen，FDC-signaling molecule 8D6，Transcobalamin receptor and 8D6A. It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recentl...
TMPJ-01344	TCblR Protein, Human, Recombinant (hFc)	Human	Human Cells
	CD320 antigen is also known as 8D6 antigen，FDC-signaling molecule 8D6，Transcobalamin receptor and 8D6A. It is a single-pass type I membrane protein and containing two LDL-receptor class A domains. CD320 has been recentl...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatid...
------------------------ More ------------------------