Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 57,000 | |||
25 mg | 在庫あり | ¥ 106,500 | |||
50 mg | 在庫あり | ¥ 157,000 | |||
100 mg | 在庫あり | ¥ 222,000 |
説明 | Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM). |
ターゲット&IC50 | AChE:12.8 μM |
In vitro | In RAW264.7 cells, Pseudocoptisine chloride (0, 60, 90 μM; 1 hour) inhibited LPS-induced NO production in a dose-dependent manner[1]. Pseudocoptisine chloride reduced levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation. Pseudocoptisine chloride (30-90 μM; 1 hour) significantly reduced the LPS-induced TNF-α and IL-6 production and their mRNA expressions[2]. |
In vivo | Pseudocoptisine chloride (2.0 mg/kg, p.o.) showed anti-amnesic activities on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) and significantly reverses cognitive impairments in mice by passive avoidance test[2]. |
別名 | Isocoptisine chloride |
分子量 | 355.77 |
分子式 | C19H14ClNO4 |
CAS No. | 30044-78-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1 mg/mL (2.81 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Pseudocoptisine chloride 30044-78-1 Neuroscience AChE Isocoptisine anti-amnestic cytokines anti-inflammatory Pseudocoptisine pro-inflammatory Isocoptisine Chloride Pseudocoptisine Chloride RAW 264.7 Cholinesterase (ChE) inhibit Isocoptisine chloride Inhibitor inhibitor