| T9862 |
Pseudocoptisine chloride
|
Isocoptisine chloride |
AChE
|
|
Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μ... |
| TN1291 |
7,3',4'-Tri-O-methylluteolin
|
5-Hydroxy-3',4',7-trimethoxyflavone |
TNF
,
COX
,
Interleukin
|
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml |
| T13864 |
Resolvin D1
|
RvD1 |
Apoptosis
|
|
Resolvin D1 (RvD1) is an endogenous pro-inflammatory mediator that blocks pro-inflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances macroph... |
| TN1131 |
Handelin
|
|
NF-κB
,
Immunology/Inflammation related
|
|
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions. |
| TN1475 |
Caulophyllogenin
|
Segetalic acid |
IL Receptor
,
TNF
,
PPAR
,
Immunology/Inflammation related
|
|
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the... |
| T4S2157 |
Campesterol
|
(24R)-5-Ergosten-3β-ol |
Endogenous Metabolite
|
|
Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory e... |
| T14149 |
AICAR phosphate
|
AICA Riboside phosphate,Acadesine phosphate |
Mitophagy
,
NOS
,
YAP
,
AMPK
|
|
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-in... |
| T6926 |
Palmitoylethanolamide
|
Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol |
Influenza Virus
,
Endogenous Metabolite
,
PPAR
|
|
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoyleth... |
| TN3460 |
Asebogenin
|
|
Antifungal
|
|
Asebogenin is a compound fractionated from Salvia miltiorrhiza with antifungal activity, inhibition of GPVI-induced platelet reactions, and inhibition of NET formation induced by pro-inflammatory stimuli. |
| T5S0167 |
Atractylenolide I
|
|
IL Receptor
,
TNF
,
TLR
,
JAK
,
STAT
|
|
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide... |
| T4S1943 |
Kirenol
|
Kirel |
Wnt/beta-catenin
|
|
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid... |
| T17214 |
Valencene
|
NSC 148969,NSC-148969,NSC148969 |
Others
,
Antioxidant
,
NF-κB
|
|
Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, an... |
| TN6722 |
Terminolic acid
|
2α,6β,23-trihydroxyl oleanolic acid |
Antibacterial
|
|
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and ... |
| T5S1895 |
Norisoboldine
|
Laurelliptine,(+)-Laurelliptine |
MAPK
,
Adenosine Receptor
|
|
1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the abnormal immune responses. 2. Norisobo... |
| TN2091 |
Polygalacin D
|
|
Apoptosis
,
IAP
|
|
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxi... |
| T5S0045 |
Isofraxidin
|
6,8-Dimethoxyumbelliferone,Phytodolor |
MMP
,
ERK
,
p38 MAPK
,
TLR
,
COX
|
|
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... |
| T4S1050 |
Pristimerin
|
Celastrol methyl ester |
NF-κB
,
Antibacterial
|
|
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell... |
| T4S1962 |
Beta-Asarone
|
Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin |
NF-κB
,
JNK
|
|
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be... |
| T4S2063 |
Tetrahydrocoptisine
|
STYLOPINE |
ERK
,
p38 MAPK
,
NF-κB
|
|
1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo... |
| T3S0737 |
Flavokawain A
|
Flavokavain A |
Apoptosis
,
p38 MAPK
|
|
NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant... |
| TCS2170 |
2,5-Dihydroxyacetophenone
|
Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP |
ERK
,
NF-κB
,
Tyrosinase
|
|
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... |
| TN1831 |
Macranthoside A
|
Kalopanaxsaponin H |
Antioxidant
|
|
Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective... |
| T2S2264 |
Linalool
|
Linalol,(±)-Linalool,Phantol |
Apoptosis
,
IL Receptor
,
TNF
,
Endogenous Metabolite
,
iGluR
|
|
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th... |
| T0798 |
Triamcinolone
|
Fluoxyprednisolone,Aristocort,Rodinolone |
Glucocorticoid Receptor
,
COX
|
|
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca... |
| T2563 |
Acetyl-L-carnitine hydrochloride
|
Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride |
Others
,
Endogenous Metabolite
|
|
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) is a nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neur... |
| T6677 |
Sophocarpine
|
|
ERK
,
p38 MAPK
,
NF-κB
,
TLR
,
COX
,
HER
,
JNK
,
STAT
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
| T3S2259 |
Methyl eugenol
|
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether |
GABA Receptor
|
|
1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its... |
| TMA2576 |
Episappanol
|
|
IL Receptor
,
TNF
|
|
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). |
| T4S1057 |
Tripdiolide
|
|
IL Receptor
,
TNF
|
|
Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis. |
| TN6566 |
Licoflavanone
|
|
|
|
Licoflavanone exhibits antioxidant and anti-inflammatory activities,it markedly decreases pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels. |
| TN4162 |
Goshonoside F5
|
|
IκB/IKK
,
p38 MAPK
,
TNF
,
NOS
,
NF-κB
,
COX
,
Prostaglandin Receptor
,
JNK
|
|
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. |
| TN6366 |
Lupinalbin A
|
|
|
|
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine... |
| TN2327 |
Zedoarondiol
|
|
NOS
,
NF-κB
,
COX
|
|
Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway. |
| TN4879 |
Questinol
|
|
IL Receptor
,
TNF
,
COX
,
Prostaglandin Receptor
|
|
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α... |
| TN1235 |
3,4,5-Tricaffeoylquinic acid
|
|
TNF
,
Akt
,
HIV Protease
|
|
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and N... |
| T81408 |
Preleoheterin
|
|
|
|
Preleoheterin (Compound 3), a labdane diterpene isolated from L. japonicus [1], exhibits anti-inflammatory properties by inhibiting the production of nitric oxide and pro-inflammatory cytokines in LPS-activated macrophag... |
| TN5912 |
Macluraxanthone
|
3-Hydroxyblancoxanthone |
Antioxidant
,
TNF
|
|
Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the p... |
| T61171 |
Cyclo(his-pro) TFA
|
|
|
|
Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone, has shown inhibitory effects on NF-κB nuclear accumulation. Additionally, it possesses the ability to cross the... |
| TN1347 |
8-Prenylkaempferol
|
|
p38 MAPK
,
NF-κB
,
PI3K
|
|
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated tran... |
| T4S0083 |
Protostemonine
|
|
Others
|
|
1. Protostemonine has anti-inflammatory activity, it effectively attenuates LPS-induced inflammatory responses in vitro and in vivo; the beneficial effects are associated with the decreased phosphorylation of MAPK and AK... |
| T27282 |
Erucin
|
AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056 |
|
|
Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-... |
| T38394 |
PSMα3
|
|
|
|
PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation ... |
| TN3779 |
De-O-methyllasiodiplodin
|
|
IL Receptor
,
TNF
,
ROS
,
Antifection
|
|
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively ... |
| TN3983 |
Ergosta-7,22-dien-3-one
|
|
NO Synthase
,
LTR
|
|
Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory properties, it stimulates nitric oxide production, induces gene expr... |
| TN2511 |
Britannilactone diacetate
|
1,6-O,O-Diacetylbritannilactone |
IL Receptor
,
PARP
,
ROS
,
MAPK
,
Caspase
,
JAK
,
JNK
,
STAT
|
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic acti... |
| TN2928 |
Pygenic acid A
|
3-Epicorosolic acid |
|
|
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid show... |
