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T2315 |
GSK-LSD1 dihydrochloride
|
GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl |
Histone Demethylase
|
|
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ... |
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T77635 |
LSD1-IN-27
|
|
Histone Demethylase
,
PD-1/PD-L1
|
|
LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited the expression of PD-L1 in BGC-823 and MFC cells.LSD1-IN-27 p... |
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T11882 |
Pulrodemstat benzenesulfonate
|
LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate |
Histone Demethylase
|
|
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. |
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T83966 |
LSD1-IN-30
|
|
Histone Demethylase
|
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LSD1-IN-30 is a lysine-specific demethylase 1 (LSD1) inhibitor with anticancer activity for the study of small cell lung cancer and acute myeloid leukemia. |
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T63140 |
LSD1-IN-20
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Histone Demethylase
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Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, w... |
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T36625 |
LSD1/HDAC6-IN-1
|
LSD1/HDAC6-IN-1 |
|
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LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ... |
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T67871 |
LSD1-IN-24
|
|
Histone Demethylase
,
PD-1/PD-L1
|
|
LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases. |
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T11880 |
LSD1-IN-5
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|
Histone Demethylase
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LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM. |
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T11881 |
LSD1-IN-6
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|
Histone Demethylase
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LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM. |
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T82254 |
GSK-LSD1
|
|
Histone Demethylase
|
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GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (... |
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T11883 |
Pulrodemstat Methylbenzenesulfonate
|
LSD1-IN-7 Methylbenzenesulfonate |
Others
|
|
LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. |
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T61022 |
LSD1-IN-17
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|
|
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LSD1-IN-17 (compound 5b) is a potent inhibitor of LSD1 that inhibits LSD1-CoREST, MAO-A and MAO-B, with IC 50 values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 exhibits cell growth arrest in prostate cancer ... |
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T61021 |
LSD1-IN-16
|
|
|
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LSD1-IN-16 (compound 4b) is a potent inhibitor of LSD1 that inhibits LSD1-CoREST, MAO-A and MAO-B with IC50 values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 exhibits cell growth arrest in prostate cancer LN... |
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T62099 |
LSD1-IN-13
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|
|
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LSD1-IN-13 (compound 7e) is an orally active LSD1 inhibitor (IC50: 24.43 nM) that also activates CD86 expression (EC50: 470 nM).LSD1-IN-13 induces differentiation of AML (acute myeloid leukaemia) cell lines. |
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T63716 |
LSD1-IN-18
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|
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LSD1-IN-18 is a potent, non-covalent, selective inhibitor of LSD1 (Ki:0.156 μM; KD: 0.075 μM).LSD1-IN-18 exhibited anti-proliferative effects in THP-1 leukemia cells and MDA-MB-231 breast cancer cells with IC50 (72 h) of... |
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T61405 |
LSD1-IN-14
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|
|
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LSD1-IN-14, a powerful and specific inhibitor of LSD1 (with an IC50 value of 0.89 μM), effectively suppresses the growth of A549 and THP-1 cells and promotes the apoptosis of tumor cells [1]. |
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T63920 |
LSD1-IN-19
|
|
|
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LSD1-IN-19 (compound 29) is a selective, potent, non-covalent inhibitor of LSD1 (Ki: 0.108 μM, KD: 0.068 μM). The 72h IC50 values were 0.17 and 0.40 μM, respectively. |
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T74855 |
LSD1-IN-25
|
|
Histone Demethylase
|
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LSD1-IN-25 (Compound 9j) is a potent, selective, and orally active inhibitor of LSD1, exhibiting an IC50 of 46 nM (Ki = 30.3 nM) and capable of inducing apoptosis in cancer cells [1]. |
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T78888 |
LSD1-UM-109
|
|
Histone Demethylase
|
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LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM. This compound exhibits strong antiproliferative activity, inhibiting cell growth with IC50 values of 0.6 nM in the MV4;11 ... |
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T60381 |
LSD1-IN-12
|
|
|
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LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively [1]. |
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T74858 |
LSD1-IN-26
|
|
|
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LSD1-IN-26 (compound 12u), a potent LSD1 inhibitor, exhibits an IC50 of 25.3 nM. It also demonstrates inhibition of MAO-A (IC50 = 1234.57 nM) and MAO-B (IC50 = 3819.27 nM), significantly inducing apoptosis in MGC-803 cel... |
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T60941 |
LSD1-IN-15
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|
|
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LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor that inhibit LSD1-CoREST, MAO-A and MAO-B with IC 50 values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 shows cell growth arrest in LNCaP cells of prostate ... |
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T60362 |
LSD1-IN-22
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|
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LSD1-IN-22 is a potent inhibitor of Lysine-specific demethylase 1 ( LSD1 ) with a K i value of 98 nM. LSD1-IN-22 has anti-proliferative activity against certain cancer cells [1]. |
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T62674 |
LSD1-IN-21
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LSD1-IN-21 is a potent, blood-brain barrier permeable LSD1 (lysine specific demethylase-1) inhibitor (IC50: 0.956 μM).LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α and exhibits good anti-cancer and... |
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T62818 |
LSD1/ER-IN-1
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LSD1/ER-IN-1 (compound 11g) is a potent inhibitor of ER and LSD1 that acts on LSD1 (IC50: 1.55 μM). LSD1/ER-IN-1 showed good anti-proliferative effect on MCF-7 breast cancer cells (IC50: 8.79 μM). |
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T60360 |
LSD1/2-IN-3
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LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 ( LSD1 ) with a Ki value of 11 nM rather than 7 μM for LSD2. There is aberrant expression of LSD1 in tumor stem cells, LSD1/2-IN-1 inhibits LSD1 cell ... |
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T62679 |
LSD1-IN-13 hydrochloride
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LSD1-IN-13 hydrochloride (compound 7e) is an orally active inhibitor of LSD1 (IC50: 24.43 nM). hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines. |
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T60361 |
LSD1/2-IN-4
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|
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LSD1/2-IN-4, a derivative of PCPA, functions as an inhibitor for both lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2), demonstrating K i values of 0.11 μM and 130 μM against LSD1 and LSD2, r... |
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T39258 |
Pulrodemstat
|
LSD1-IN-7,CC-90011 |
|
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Pulrodemstat (CC-90011) is a highly potent and selective inhibitor of lysine specific demethylase-1 (LSD1). It exhibits a reversible mode of action and can be administered orally. With an impressive IC50 of 0.25 nM, Pulr... |
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T6073 |
OG-L002
|
|
Histone Demethylase
,
Monoamine Oxidase
,
HSV
|
|
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively. |
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T21652 |
RN-1 dihydrochloride
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|
Histone Demethylase
,
MAO
|
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RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM). |
|
T3677 |
GSK2879552
|
GSK2879552 2HCl |
Histone Demethylase
|
|
GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity. |
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T2304 |
SP2509
|
HCI-2509 |
Apoptosis
,
Histone Demethylase
|
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SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM). |
|
T4527 |
Seclidemstat
|
SP-2577 |
Histone Demethylase
|
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Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM. |
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T4418 |
GSK2879552 2HCl (1401966-69-5(free base))
|
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Histone Demethylase
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GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. |
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T13055 |
T-3775440 hydrochloride
|
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Histone Demethylase
|
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T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM). |
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T10983L |
DDP-38003 dihydrochloride
|
|
Histone Demethylase
|
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DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM). |
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T10864 |
Corin
|
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Histone Demethylase
,
HDAC
|
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Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM). |
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T39252 |
TAK-418
|
|
Histone Demethylase
|
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TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM. TAK-418 unlocks abnormal epigenetic mechanisms and improves autism symptoms in models of neurodevelopmental disorders. |
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T6922 |
ORY1001
|
RG-6016,ORY-1001 (RG-6016) 2HCl,ORY-1001,ORY 1001 |
Histone Demethylase
|
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ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM. |
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T5825 |
Iadademstat dihydrochloride
|
ORY-1001(trans) |
Histone Demethylase
|
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Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia. |
|
T17211 |
Vafidemstat
|
ORY-2001 |
Histone Demethylase
,
MAO
|
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Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases. |
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T7942 |
Tranylcypromine hemisulfate
|
Tranylcypromine Sulfate,Tranylcypromine (hemisulfate) |
Histone Demethylase
,
MAO
,
Monoamine Oxidase
|
|
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity. |
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T4477 |
Domatinostat tosylate
|
4SC-202 tosylate,4SC-202 |
Apoptosis
,
HDAC
|
|
Domatinostat tosylate (4SC-202) is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethylase 1 (LSD1). |
|
T6362 |
Domatinostat
|
4SC202,4SC 202,4SC-202 (free base),4SC-202 |
Apoptosis
,
HDAC
|
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Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (L... |
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T77334 |
HDAC-IN-57
|
|
Apoptosis
,
HDAC
|
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HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with ... |
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T13057 |
T-448
|
|
Histone Demethylase
|
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T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM). |
|
T13056 |
T-448 free base
|
|
Histone Demethylase
|
|
T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM). |
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T10983 |
DDP-38003 trihydrochloride
|
|
Others
|
|
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM. |
|
T11503 |
GSK 690 Hydrochloride
|
|
Histone Demethylase
|
|
GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM. |
