Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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500 mg | 在庫あり | ¥ 10,500 | |||
1 g | 在庫あり | ¥ 12,500 | |||
5 g | 在庫あり | ¥ 35,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. |
別名 | Proamipide, OPC12759 |
分子量 | 370.79 |
分子式 | C19H15ClN2O4 |
CAS No. | 90098-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 6.88 mg/mL (18.54 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rebamipide 90098-04-7 GPCR/G Protein Immunology/Inflammation Neuroscience oxidation-reduction Free radical scavengers Prostaglandin Receptor COX AGS cells inhibit mucosal protection gastroduodenal ulcer Inhibitor OPC-12759 COX-2 gastric cancer Cyclooxygenase PGE2 Proamipide OPC12759 OPC 12759 gastritis inhibitor