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T63104 |
INOS/PGE2-IN-1
|
|
|
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iNOS/PGE2-IN-1 is an iNOS/PGE2 inhibitor and a potent anti-inflammatory agent. iNOS/PGE2-IN-1 exhibits an inhibitory effect on LPS-induced NO production and has a low ulcerogenic potential. |
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T83773 |
Prostaglandin E2 Inhibitor 3
|
PGE2 Inhibitor 3 |
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Prostaglandin E2 (PGE2) inhibitor 3 is a selective inhibitor targeting microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM), demonstrating greater selectivity for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO... |
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T78582 |
15-keto-Prostaglandin E2
|
15-keto-PGE2 |
Prostaglandin Receptor
|
|
15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression. Additionally, it binds and stabilizes the EP2 and EP4 recep... |
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T10046 |
16,16-Dimethyl prostaglandin E2
|
16,16-dimethyl PGE2 |
Prostaglandin Receptor
|
|
16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway. |
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T83779 |
EP4 Antagonist 14
|
Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 |
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EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A... |
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TQ0105 |
CAY10650
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Phospholipase
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CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM). |
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T38163 |
ML-148
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Dehydrogenase
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ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostagla... |
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T23861 |
CAY10526
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CAY-10526,BTH,CAY 10526 |
Prostaglandin Receptor
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CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway. |
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T50005 |
Sertaconazole
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Antifungal
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Sertaconazole is a broad-spectrum antifungal. |
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T1867 |
Otenaproxesul
|
ATB 346 |
Apoptosis
,
COX
|
|
Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. |
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T2577 |
Dienogest
|
STS 557 |
Apoptosis
,
Estrogen/progestogen Receptor
,
Progesterone Receptor
,
Autophagy
|
|
Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therap... |
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T1562 |
Rebamipide
|
Proamipide,OPC12759 |
Free radical scavengers
,
COX
,
Prostaglandin Receptor
|
|
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ... |
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T36683 |
Vedaprofen
|
Quadrisol,PM 150,CERM 10202 |
COX
,
Antibacterial
,
Prostaglandin Receptor
|
|
Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM. |
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T6665 |
Sertaconazole nitrate
|
FI-7045,Ginedermofix,FI7056,Ertaczo |
Antibiotic
,
Antifungal
|
|
Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections. |
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T12352 |
Oxidopamine hydrochloride
|
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride |
Mitophagy
,
Dopamine Receptor
,
Autophagy
|
|
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist. |
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T12352L |
Oxidopamine hydrobromide
|
6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide |
Mitophagy
,
Dopamine Receptor
,
Autophagy
|
|
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist. |
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TQ0292 |
Grapiprant
|
AAT-007,RQ-00000007,CJ-023423 |
Prostaglandin Receptor
|
|
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). |
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T8763 |
PTGR2-IN-1
|
PTGR2-IN-22 |
Others
|
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PTGR2-IN-1 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells. |
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T36619 |
Aligeron
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|
Prostaglandin Receptor
|
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Aligeron is a non-selective prostaglandin (PG) antagonist that inhibits PGF2α- and PGE2-induced decreases in blood pressure in cats, and can be used to inhibit PGF2α-induced diarrhea in mice and PGE2-induced paw edema in... |
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T2121 |
SW033291
|
|
Dehydrogenase
|
|
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues. |
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T23331 |
SC 51089
|
SC 51089 free base |
Prostaglandin Receptor
|
|
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... |
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T3306 |
PF-04418948
|
PF 04418948,PF04418948 |
Prostaglandin Receptor
|
|
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... |
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T67766 |
HHS-0701
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|
Others
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HHS-0701 is a sulfur-triazole exchange (SuTEx) ligand. HHS-0701 is a potent inhibitor of tyrosine-reactive prostaglandin reductase 2 (PTGR2). HHS-0701 can block PTGR2 metabolism of the lipid substrate 15-Keto-PGE2. |
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T15681 |
L-161982
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|
Prostaglandin Receptor
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L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice. |
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T67946 |
EP2 receptor antagonist-2
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|
Prostaglandin Receptor
|
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EP2 receptor antagonist-2 (CID891729) is a compound that not only serves as an antagonist to the EP2 receptor, blocking its activation by PGE2, but also reduces lactate dehydrogenase (LDH) release triggered by N-methyl-D... |
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T21738 |
PF-9184
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|
Prostaglandin Receptor
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PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro. |
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T10381 |
AS2717638
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|
Others
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AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2α-, PGE2-, and AMPA-induced allodynia. |
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T15108 |
DG-041
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|
Prostaglandin Receptor
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DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per... |
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T14975 |
CJ-42794
|
CJ-042794 |
Others
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CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... |
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T15259 |
Evatanepag
|
CP-533536 free acid |
Prostaglandin Receptor
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|
Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l... |
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T62061 |
COX-2-IN-6
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|
COX
,
Prostaglandin Receptor
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|
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u... |
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T6414 |
Bisacodyl
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Fenilaxan,Dulcolax,Brocalax |
Others
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Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. |
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T28958 |
TG6-129
|
TG6 129 |
Prostaglandin Receptor
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|
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and... |
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T68155 |
Tebufelone
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|
Prostaglandin Receptor
,
LTR
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|
Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticul... |
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T35610 |
2,5-dimethyl Celecoxib
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|
Apoptosis
,
Wnt/beta-catenin
,
Prostaglandin Receptor
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
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T12103 |
MR-L2
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|
PDE
|
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MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4). |
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T36728 |
9-deoxy-9-methylene Prostaglandin E2
|
9-deoxy-9-methylene Prostaglandin E2 |
|
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9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 . 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methyl... |
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T38342 |
11-deoxy Prostaglandin E2
|
11-deoxy Prostaglandin E2 |
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11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory trac... |
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T36168 |
8-iso-16-cyclohexyl-tetranor Prostaglandin E2
|
8-iso-16-cyclohexyl-tetranor Prostaglandin E2 |
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8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no ... |
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T26497 |
AAT-008
|
AAT008 |
|
|
AAT-008 is a PGE2 receptor EP4 antagonist. |
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T37839 |
20-hydroxy Prostaglandin E2
|
20-hydroxy Prostaglandin E2 |
|
|
20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent m... |
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T27981 |
MB-28767
|
M&B 28767,MB28767 |
|
|
MB-28767 is an agonist of prostaglandin E2 (PGE2) receptor. |
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T71594 |
SC 42867
|
|
|
|
SC 42867 is a PGE2 antagonist. |
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T35991 |
Ent-Prostaglandin E2
|
ent-Prostaglandin E2 |
|
|
Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of P... |
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T36144 |
11β-Prostaglandin E2
|
11β-PGE2,11β-Prostaglandin E2 |
|
|
11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-... |
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T37773 |
Tetranor-PGEM
|
tetranor-Prostaglandin E Metabolite,tetranor-PGEM |
|
|
tetranor-PGEM is the major urinary metabolite of PGE1 and PGE2, and is used as a marker of PGE2 biosynthesis.[1],[2] About 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy ... |
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T36154 |
15(S)-15-methyl Prostaglandin E2
|
15(S)-15-methyl Prostaglandin E2 |
|
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15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is te... |
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T37996 |
17-phenyl trinor Prostaglandin E2 ethyl amide
|
17-phenyl trinor Prostaglandin E2 ethyl amide |
|
|
17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rat... |
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T27243 |
Efipladib
|
PLA-902,PLA 902,PLA902 |
|
|
Efipladib is a phospholipase inhibitor. Efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid. |
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T36762 |
KW-8232
|
|
|
|
KW-8232, an orally active anti-osteoporotic agent, reduces the biosynthesis of PGE2[1]. |
