Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.
説明 | Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects. |
In vitro | Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[1]. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[2]. |
In vivo | Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model[1]. |
別名 | Ro 24-7429, Ro-24-7429, Ro 247429 |
分子量 | 272.73 |
分子式 | C14H13ClN4 |
CAS No. | 139339-45-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (220.00 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Ro24-7429 139339-45-0 Microbiology/Virology Proteases/Proteasome HIV Protease Tat anti-inflammatory antifibrotic inhibit Ro247429 RUNX1 Inhibitor Ro 24-7429 Ro-24-7429 Apoptosis Human immunodeficiency virus HIV-1 anti-HIV Ro24 7429 Ro 247429 HIV inhibitor