Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
説明 | SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively). |
ターゲット&IC50 | SIRT1:4 nM, SIRT3:7 nM, SIRT2:1 nM |
In vitro | SIRT-IN-2 is one of the most potent truncated pan SIRT1/ 2/3 inhibitor(IC50 values are 4, 4, 7 μM, respectively). SIRT-IN-2 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. |
分子量 | 383.49 |
分子式 | C15H21N5O3S2 |
CAS No. | 1431411-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (151.24 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SIRT-IN-2 1431411-66-3 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor SIRT IN 2 inhibit SIRTIN2 inhibitor