Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
説明 | SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer. |
In vitro | SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7 [2]. |
In vivo | Oral administration of 0.1 mg/kg SM-276001 in mice shows potent IFN-inducing activity [1]. Twice weekly oral administration of SM-276001 at a dose of 3 mg/kg significantly reduced disease burden in mice bearing either Renca or CT26 tumors.[2]. |
分子量 | 327.38 |
分子式 | C16H21N7O |
CAS No. | 473930-22-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (305.46 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SM-276001 473930-22-2 Immunology/Inflammation Neuroscience TLR COX immune IFNAR Interferon-alpha/beta receptor IFN Toll-like Receptor (TLR) inhibit TLR7 Inhibitor Interferon-α/β receptor interferon SM 276001 antitumor SM276001 inhibitor