Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 19,500 | |||
10 mg | 在庫あり | ¥ 30,000 | |||
25 mg | 在庫あり | ¥ 66,000 | |||
50 mg | 在庫あり | ¥ 110,500 | |||
100 mg | 在庫あり | ¥ 158,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. |
In vitro | SP141, which bound directly to MDM2, promoting its auto-ubiquitination and degradation by the proteasome.?The compound reduced levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation, with 50% inhibitory concentrations <0.5 μM (0.38-0.50 μM).?Increasing concentrations of SP141 induced increasing levels of apoptosis and G2-M-phase arrest of pancreatic cancer cell lines, whether or not they expressed functional P53[1]. |
In vivo | Injection of nude mice with SP141 (40 mg/kg/d) inhibited growth of xenograft tumors (by 75% compared with control mice), and led to regression of orthotopic tumors[1]. |
別名 | SP 141 |
分子量 | 324.38 |
分子式 | C22H16N2O |
CAS No. | 1253491-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.4 mg/mL (13.56 mM)
You can also refer to dose conversion for different animals. 詳細
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SP-141 1253491-42-7 Apoptosis Mdm2 pancreatic inhibit SP 141 Inhibitor cancer MDM-2/p53 breast degradation SP141 auto-ubiquitination inhibitor