検索結果

Search Results for " antidiabetic "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T79644	Antidiabetic agent 2		Glucosidase
	Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. This agent effectively decre...		Glucosidase
T15385	Glibornuride		Potassium Channel
	Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.		Potassium Channel
T31976	Glymidine sodium		Others
	Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.		Others
T8224	VU0119498		AChR
	VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.		AChR
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T9590	T-1095		SGLT , transporter
	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).		SGLT , transporter
T15656	KGA-2727		SGLT
	KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA...		SGLT
T6759	AP-III-a4	ENOblock	Glucokinase
	AP-III-a4 (ENOblock) (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.		Glucokinase
T38843	Enavogliflozin	DWP-16001	SGLT
	Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor.		SGLT
T22967	MEDICA16	MEDICA 16	GPR , Others , ATP Citrate Lyase
	Free fatty acid 1 (FFA1/GPR40) receptor agonist		GPR , Others , ATP Citrate Lyase
T16074	Mifobate	SR-202	PPAR
	Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].		PPAR
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
			Apoptosis , PDK
T2607	MSDC 0160	CAY10415,Mitoglitazone,MSDC0160,MSDC-0160	Others , IGF-1R , Mitochondrial Metabolism
	MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.		Others , IGF-1R , Mitochondrial Metabolism
T20029	Buformin hydrochloride	NSC528218,NSC-528218,NSC 528218	AMPK
	Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and...		AMPK
T16083	Mizagliflozin	GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT
	Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca...		SGLT
T8345	Carbutamide		Others
	Carbutamide is a sulfonylurea antidiabetic agent with hypoglycemic activity.		Others
T22382	NSC 31150		Antioxidant , Antibiotic , PPAR
	NSC 31150 is a potential PPAR agonist with antibacterial, antidiabetic and antioxidant activities and may be used to study cancer and bacterial infections.		Antioxidant , Antibiotic , PPAR
T22708	Darglitazone	CP-86325	PPAR
	Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.		PPAR
T10561	BM-131246		Others
			Others
T29019	TS-021	TS021,TS 021,TS-021 Free	DPP-4
	TS-021 is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor with antidiabetic activity for the study of type 2 diabetes.		DPP-4
T9999	Sirtuin modulator 2	N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others , Sirtuin
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.		Others , Sirtuin
T11942	MAP4K4-IN-3	Compound 17	MAPK
	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.		MAPK
T12400	Peliglitazar racemate	(Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate	PPAR
			PPAR
TP2320	Pramlintide acetate(151126-32-8 free base)		Others
	Pramlintide acetate is a polypeptide analogue of human amylin. It serves as an antidiabetic agent and exhibits antineoplastic activity in colorectal cancer.		Others
T8750	LX-4211 intermediate		Others
	LX-4211 intermediate is a synthetic intermediate of LX-4211, a potent SGLT1/2 inhibitor used as an antidiabetic agent.		Others
T9178	(E/Z)-GSK-3β inhibitor 1	GSK-3β inhibitor 1	GSK-3
	(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.		GSK-3
T11467	GSK-3β inhibitor 1		GSK-3
	GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.		GSK-3
T8615	ISOTHIAZOLINE 1,1-DIOXIDE	isothiazolidine 1,1-dioxide	Others
	ISOTHIAZOLINE 1,1-DIOXIDE (isothiazolidine 1,1-dioxide) is a reactant used in the synthesis of orally bioavailable hebatits B caspid inhibitors, and in the preparation of cryptochrome imhibitors as antidiabetic agents.		Others
T67898	α-Glucosidase-IN-22		Glucosidase
	α-Glucosidase-IN-22 is a selective inhibitor of α-glucosidase (IC50=0.64 μM). α-Glucosidase-IN-22 has antidiabetic activity and has potential in type 2 diabetes (T2DM) studies.		Glucosidase
T1622	Rosiglitazone maleate	BRL 49653C,BRL 49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T3984	GLP-1(7-36), amide	MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor
	GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-...		Glucagon Receptor
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T23389	SR1664	SR 1664	PPAR
	SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPAR...		PPAR
T73578	JY-2		FOXO1
	JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes.		FOXO1
T0214L	Pioglitazone hydrochloride	U-72107E,AD 4833,U 72107A,Pioglitazone HCl	Ferroptosis , PPAR
	Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.		Ferroptosis , PPAR
T27402	Garvagliptin
	Garvagliptin has antidiabetic activity.
T31627	Englitazone sodium	CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)
	Englitazone sodium is an antidiabetic agent and a novel NSCA and KATP channel blocker.
T38998	Pramlintide
	Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.
T61503	α-Glucosidase-IN-15
	α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM. It possesses antidiabetic properties [1].
T11248	Evogliptin tartrate	DA-1229 tartrate	DPP-4
	Evogliptin tartrate has potential for anti-atherosclerosis therapy that targets arterial inflammation. Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with ant...		DPP-4
T68445	Clomoxir
	Clomoxir is a carnitine palmitoyltransferase I inhibitor that was under development as an antiarrhythmic and antidiabetic.
T22860	Imeglimin		Others
	Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents. It has been shown to act on the liver, muscle, and pancreatic β-cells to uniquely target the key defects of type 2 diabetes...		Others
T23837	Buformin	W37,W 37,H 224,W-37
	Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class. It also inhibits the synthesis of glucose by the liver. Buformin delays absorption of glucose from the gastrointestinal tract increases ins...
T61519	α-Glucosidase-IN-18
	α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1].
T62891	α-Glucosidase-IN-19
	Alpha-Glucosidase-IN-19 (Compound 6B) is an orally active alpha-glucosidase inhibitor (IC50: 3.63 μM) with antidiabetic effects.
T14040	4-Hydroxytolbutamide	Hydroxytolbutamide	Potassium Channel
	4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].		Potassium Channel
T70280	KB-R7785
	KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect b...
T79911	O-Benzoylhydroxylamine
	O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].
T61249	α-Glucosidase-IN-2
	α-Glucosidase-IN-2 (compound 5d) is a potent inhibitor of α-Glucosidase, exhibiting an inhibitory concentration (IC50) of 9.48 μM, and functions as an antidiabetic agent [1].
T80711	α-Glucosidase-IN-39		Glucosidase
	α-Glucosidase-IN-39 is a potent α-glucosidase enzyme inhibitor, exhibiting an IC50 value of 869.06 ppm. It is applicable for use in antidiabetic studies [1].		Glucosidase

Compounds

Antidiabetic agent 2

Target: Potassium Channel

Target: Apoptosis, PERK

T-1095

T9590

Synonym:

Target: SGLT, transporter

Target: GPR, Others, ATP Citrate Lyase

PDK4-IN-1 hydrochloride

T12412L

Synonym:

Target: Apoptosis, PDK

MSDC 0160

T2607

Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160

Target: Others, IGF-1R, Mitochondrial Metabolism

Buformin hydrochloride

T20029

Synonym: NSC528218,NSC-528218,NSC 528218

Target: AMPK

Mizagliflozin

T16083

Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base

Target: Antioxidant, Antibiotic, PPAR

Synonym: TS021,TS 021,TS-021 Free

Target: DPP-4

Sirtuin modulator 2

T9999

Synonym: N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide

Target: Others, Sirtuin

Peliglitazar racemate

T12400

Synonym: (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate

Target: PPAR

Pramlintide acetate(151126-32-8 free base)

(E/Z)-GSK-3β inhibitor 1

T9178

Synonym: GSK-3β inhibitor 1

ISOTHIAZOLINE 1,1-DIOXIDE

T8615

Synonym: isothiazolidine 1,1-dioxide

Rosiglitazone maleate

T1622

Synonym: BRL 49653C,BRL 49653

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

GLP-1(7-36), amide

T3984

Synonym: MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide

Target: Glucagon Receptor

Glibenclamide

T1634

Synonym: Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Pioglitazone hydrochloride

T0214L

Synonym: U-72107E,AD 4833,U 72107A,Pioglitazone HCl

Target: Ferroptosis, PPAR

Synonym: CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)

Synonym: DA-1229 tartrate

Synonym: W37,W 37,H 224,W-37

Synonym: Hydroxytolbutamide

Target: Potassium Channel

O-Benzoylhydroxylamine

カタログ番号	製品名	別名	ターゲット
TN1128	Bruceine E		Others
	Bruceine E is isolated from B. javanica seeds with hypoglycemia effects. Bruceine E can be used for studies about acting as an insulin secretagogue.		Others
TN1026	Vomicine		Others
	Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals.		Others
TN6771	Malabaricone B		Others
	Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway.		Others
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
TN1403	Arjunolic acid		IL Receptor , TNF , Reactive Oxygen Species , JNK , AChE
	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheim...		IL Receptor , TNF , Reactive Oxygen Species , JNK , AChE
T0795	Rutin	Quercetin 3-O-rutinoside,Rutoside	Beta Amyloid , Prostaglandin Receptor , Autophagy
	Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.		Beta Amyloid , Prostaglandin Receptor , Autophagy
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
T4723	D-Tagatose	D-(-)-Tagatose,d-tagatos	Others , Endogenous Metabolite
	D-Tagatose (D-(-)-Tagatose), a rare natural hexoketose, is an isomer of d-galactose. D-Tagatose occurs naturally in Sterculia setigera gum, and it is also found in small quantities in various foods such as sterilized and...		Others , Endogenous Metabolite
T3S1319	(+)-Magnoflorine	Escholin,Magnoflorine,Thalictrin,Escholine	Others , Antifungal
	(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mech...		Others , Antifungal
TL0006	Cichoric Acid	Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species , HIV Protease
	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and ...		Reactive Oxygen Species , HIV Protease
T22417	Rutin hydrate	Rutoside,Sophorin,Quercetin-3-O-rutinoside	Beta Amyloid , Others , Autophagy
	Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.		Beta Amyloid , Others , Autophagy
T3S1320	(+)-Magnoflorine iodide	Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide	Others , Antifungal
	(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations.		Others , Antifungal
T2902	Costunolide	Costus lactone,NSC 106404,Costunolid,(+)-Costunolide	Apoptosis , Endogenous Metabolite , Telomerase
	Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis.		Apoptosis , Endogenous Metabolite , Telomerase
T4S1321	(+)-Magnoflorine chloride	Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride	Others , Antifungal
	(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations.		Others , Antifungal
T8300	Mogroside IV-E	mogroside Ive	Antioxidant
	Mogroside IV-E is a triterpenoid glycoside isolated from the extracts of Luo Han Guo. Mogrosides exhibit antidiabetic, antioxidant and anticancer activities.		Antioxidant
T2S1194	Mogroside II-A2		Others
	Mogroside II-A2 is a natural product from Siraitia grosvenorii Swingle. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.		Others
T2927	Trigonelline chloride	Gynesine Hydrochloride,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride	Others , Antibacterial , Antifungal , HSV
	Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Others , Antibacterial , Antifungal , HSV
T67709	Hispolon		Others
	Hispolon is a polyphenol. Hispolon can be isolated from Phellinus linteus. Hispolon exhibits anticancer, antidiabetic, antiviral, hepatoprotective, antioxidant, and anti-inflammatory activities.		Others
T2887	Trigonelline	Trigenolline	Apoptosis , Others , Ferroptosis , Endogenous Metabolite
	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Apoptosis , Others , Ferroptosis , Endogenous Metabolite
T4842	1H-pyrazole	1,2-Diazole,Pyrazole	Others , Endogenous Metabolite
	1H-pyrazole (1,2-Diazole), is a versatile building block, with a vast applications in organic synthesis. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythm...		Others , Endogenous Metabolite
TN2247	Swertisin		Adenosine Receptor
	Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects.		Adenosine Receptor
TN6718	Dehydrocostuslactone		Others
	Dehydrocostuslactone is a natural product extracted from Aucklandia.It has wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal, antioxidant, antidiabetic, an...		Others
TN1934	Mogroside IIA1	Mogroside II-A1	Others , NO Synthase
	Mogroside IIA1 (Mogroside II-A1) is isolated from the fruits of Siraitia grosvenorii. Mogroside IIA1 is a a nonsugar sweetener and sweeter than sucrose. Mogroside IIA1 possesses antioxidant, antidiabetic and anticancer a...		Others , NO Synthase
T3S1196	Mogroside IV		Others
	Mogrosides IV is a sweet minor cucurbitane glycoside, it exhibits maltase inhibitory effect(IC50 : 10 mM), and with antioxidant, antidiabetic and anticancer activities.		Others
T8202	Kaempferol 3-O-gentiobioside	Kaempferol 3-gentiobioside	Glucosidase
	Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a carbohydrate enzyme inhibitory effect (IC50: 50 μM).		Glucosidase
T4S0795	Berberrubine chloride	9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline	IL Receptor
	1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expressio...		IL Receptor
TN1100	Nepodin		transporter , COX , AMPK , Parasite
	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 tra...		transporter , COX , AMPK , Parasite
T6S0232	Eriodictyol	Huazhongilexone	Influenza Virus , DNA/RNA Synthesis , Nrf2 , Endogenous Metabolite
	1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3....
TN1215	(2S)-2'-Methoxykurarinone	2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt , Antifection
	(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteo...		Akt , Antifection
TN1712	Gossypin		NF-κB , S6 Kinase
	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i...		NF-κB , S6 Kinase
T5S0384	Rhapontin	Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis , Others
	1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as ...		Apoptosis , Others
T6718	Zingerone	Gingerone,Vanillylacetone,NSC 15335	NF-κB
	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipolytic, antispasmodic and anti-tumor properties. Zingerone(Gi...		NF-κB
TN1036	Gomisin D		Others
	Gomisin D is a natural product		Others
TN1206	2,4,6-Trihydroxybenzaldehyde		Others
	2,4,6-Trihydroxybenzaldehyde is a natural product		Others
TJS0387	Desoxyrhaponticin	Deoxyrhapontin,Deoxyrhaponticin	Apoptosis , Fatty Acid Synthase
	1. Desoxyrhaponticin (Deoxyrhaponticin) is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explained, in part at least...		Apoptosis , Fatty Acid Synthase
TN6926	Paeonoside		Others
	Paeonoside, found in P. suffruticosa, is biologically active and can promote wound healing and migration during osteoblast differentiation. Paeonoside has certain antidiabetic activity and may prevent sepsis and death fr...		Others
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin
TN1945	Momordicoside K		Others
	Momordicoside K has antidiabetic activity.		Others
TN4576	Momordicine II		Others
	Momordicine II may have antidiabetic activity, it significantly stimulated insulin secretion. It also can deter oviposition by L. trifolii significantly.		Others
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
TN2045	Pelargonidin-3-O-glucoside chloride		Others , Estrogen/progestogen Receptor
	Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrogenic, and angiotensin-converting enzyme ...		Others , Estrogen/progestogen Receptor
T68746	Chaetochromin
	Chaetochromin also known as 4548-G05 and NSC 345647, is an orally active, small-molecule, selective agonist of the insulin receptor. It has potent and long-lasting antidiabetic activity in vivo in mice.
TN2095	Pomiferin		NOS , NF-κB , PDE
	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.		NOS , NF-κB , PDE
T3930	Taraxerol acetate	Taraxeryl acetate	Phosphatase , HSV
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activ...		Phosphatase , HSV
T12089	Mogroside I A1		Others
	Mogroside I A1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, exhibiting antioxidant, antidiabetic and anticancer activities.		Others
T80008	Stevisaliosides D		Phosphatase
	Stevisaliosides D (Compound 5), extracted from the roots of Stevia serrata, exhibits inhibition of PTP1B with an IC50 of 31.8 μM and has applications in antidiabetic research [1].		Phosphatase
TN1462	Cajanin		ERK , MEK , Akt
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose up...		ERK , MEK , Akt
TMA0127	Ficusin A		transporter , PPAR
	Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPAR...		transporter , PPAR
T83562	(2R)-Flavanomarein
	'(2R)-Flavanomarein, a major flavonoid from Coreopsis tinctoria Nutt, exhibits protective effects against diabetic nephropathy and possesses antioxidative, antidiabetic, antihypertensive, and anti-hyperlipidemic properti...
------------------------ More ------------------------

天然物製品

Target: Tyrosinase, COX, HDAC, AChR

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Rutin

T0795

Synonym: Quercetin 3-O-rutinoside,Rutoside

Target: Beta Amyloid, Prostaglandin Receptor, Autophagy

Marein

TN1911

Synonym:

Target: transporter, Akt, HDAC, AMPK

D-Tagatose

T4723

Synonym: D-(-)-Tagatose,d-tagatos

Target: Others, Endogenous Metabolite

(+)-Magnoflorine

T3S1319

Synonym: Escholin,Magnoflorine,Thalictrin,Escholine

Target: Others, Antifungal

Cichoric Acid

TL0006

Synonym: Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

Rutin hydrate

T22417

Synonym: Rutoside,Sophorin,Quercetin-3-O-rutinoside

Target: Beta Amyloid, Others, Autophagy

(+)-Magnoflorine iodide

T3S1320

Synonym: Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide

Target: Others, Antifungal

Costunolide

T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide

Target: Apoptosis, Endogenous Metabolite, Telomerase

(+)-Magnoflorine chloride

T4S1321

Synonym: Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride

Target: Others, Antifungal

Mogroside IV-E

T8300

Synonym: mogroside Ive

Trigonelline chloride

T2927

Synonym: Gynesine Hydrochloride,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride

Target: Others, Antibacterial, Antifungal, HSV

Synonym: Trigenolline

Target: Apoptosis, Others, Ferroptosis, Endogenous Metabolite

1H-pyrazole

T4842

Synonym: 1,2-Diazole,Pyrazole

Target: Others, Endogenous Metabolite

Swertisin

TN2247

Synonym:

Target: Adenosine Receptor

Synonym: Mogroside II-A1

Target: Others, NO Synthase

Kaempferol 3-O-gentiobioside

T8202

Synonym: Kaempferol 3-gentiobioside

Target: Glucosidase

Berberrubine chloride

T4S0795

Synonym: 9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline

Target: transporter, COX, AMPK, Parasite

Eriodictyol

T6S0232

Synonym: Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

(2S)-2'-Methoxykurarinone

TN1215

Synonym: 2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Gossypin

TN1712

Synonym:

Target: NF-κB, S6 Kinase

Rhapontin

T5S0384

Synonym: Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

Zingerone

T6718

Synonym: Gingerone,Vanillylacetone,NSC 15335

2,4,6-Trihydroxybenzaldehyde

Synonym: Deoxyrhapontin,Deoxyrhaponticin

Target: Apoptosis, Fatty Acid Synthase

Target: TNF, Tyrosinase, Interleukin

Pelargonidin-3-O-glucoside chloride

TN2045

Synonym:

Target: Others, Estrogen/progestogen Receptor

Target: NOS, NF-κB, PDE

Taraxerol acetate

T3930

Synonym: Taraxeryl acetate

Target: Phosphatase, HSV

Target: ERK, MEK, Akt

Ficusin A

TMA0127

Synonym:

Target: transporter, PPAR

--------- More ---------

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-06935	FGF-21 Protein, Human, Recombinant	Human	E. coli
	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes ...
TMPY-00779	DPP4/CD26 Protein, Human, Recombinant	Human	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-00221	DPP4/CD26 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-00778	DPP4/CD26 Protein, Human, Recombinant (hFc)	Human	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-00122	DPP4/CD26 Protein, Human, Recombinant (His)	Human	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-01889	FGF-21 Protein, Human, Recombinant (His)	Human	E. coli
	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes ...
TMPY-02139	FGF-21 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes ...
TMPY-05794	FGF-21 Protein, Hamster, Recombinant (His)	Hamster	HEK293
	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes ...
TMPY-00074	DPP4/CD26 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-03952	DPP4/CD26 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-04046	DPP4/CD26 Protein, Cynomolgus, Recombinant	Cynomolgus	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...
TMPY-04251	DPP4/CD26 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the...