Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 35,500 | |||
10 mg | 在庫あり | ¥ 64,000 | |||
25 mg | 在庫あり | ¥ 102,500 | |||
50 mg | 在庫あり | ¥ 151,000 |
説明 | TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. |
ターゲット&IC50 | ERB3:23 nM |
In vitro | TX1-85-1 has an anti-proliferation (EC50s: 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively) [1]. |
分子量 | 580.68 |
分子式 | C32H36N8O3 |
CAS No. | 1603845-32-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.85 mg/mL (6.63 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TX1-85-1 1603845-32-4 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR inhibit TX1851 ErbB-1 Epidermal growth factor receptor Inhibitor HER1 TX1 85 1 TX-1-85-1 inhibitor