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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T1779 | SAG | Smoothened Agonist (SAG) HCl,Smoothened Agonist | Hedgehog/Smoothened , Smo |
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. | |||
T4211 | SAG hydrochloride (912545-86-9(free base)) | Smoothened Agonist HCl | Hedgehog/Smoothened |
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist. | |||
T3460 | HhAntag | Hedgehog/Smoothened , Smo | |
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity. | |||
T22814 | GSA-10 | Hedgehog/Smoothened | |
Smoothened (Smo) receptor agonist | |||
T12109 | MRT-83 | Smo | |
MRT-83 is a potent Smo antagonist. | |||
T14188 | ALLO-2 | Hedgehog/Smoothened , Smo | |
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. | |||
T2450 | SANT-1 | SANT 1 | Hedgehog/Smoothened , Smo |
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). | |||
T6891 | MK-4101 | Apoptosis , Hedgehog/Smoothened , Smo | |
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells. | |||
T9531 | MRT-14 | Smo | |
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies. | |||
T6514 | Glasdegib | PF-04449913 | Hedgehog/Smoothened , Smo |
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. | |||
T2666 | Taladegib | LY2940680 | Hedgehog/Smoothened , Smo |
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. | |||
T1810 | Purmorphamine | Shh Signaling Antagonist VI | Hedgehog/Smoothened , Smo , Autophagy |
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation. | |||
T24159 | IHR-1 | IHR 1 | Smo |
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. | |||
T11838 | LEQ506 | NVP-LEQ506 | Smo |
T5465 | PF-5274857 | PF-5274857 freebase | Smo |
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t... | |||
T9532 | MRT-81 | Others | |
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance... | |||
T2299 | BMS-833923 | XL-139 | Apoptosis , Hedgehog/Smoothened , Smo |
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM). | |||
T23027 | MRT-10 | Hedgehog/Smoothened | |
MRT-10 is a Smoothened (Smo) receptor antagonist. | |||
T1926 | Sonidegib | Erismodegib,NVP-LDE225,LDE225 | Hedgehog/Smoothened , Smo |
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | |||
T0107 | Halcinonide | Halcimat,Halciderm,Halcinonida,SQ-18566 | Glucocorticoid Receptor , Smo |
Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations. | |||
T2250 | DY131 | DY 131,GSK 9089,DY-131 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo |
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ. | |||
T15727 | Sonidegib diphosphate | NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate | Smo |
Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively). | |||
T23370 | SMANT hydrochloride | N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride,hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide;hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide,SMANT HCl,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride | Hedgehog/Smoothened |
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation. | |||
T15019 | CUR61414 | Hedgehog/Smoothened | |
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). | |||
T40465 | SAG dihydrochloride | Hedgehog/Smoothened | |
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo. | |||
T63429 | SMO-IN-2 | Hedgehog/Smoothened | |
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c... | |||
T15019L | CUR61414 hydrochloride | CUR61414 hydrochloride (334998-36-6 Free base) | Hedgehog/Smoothened |
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively... | |||
T64351 | GI-560192 | RL-0070933 | Smo |
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. | |||
T24754 | Hh-Ag1.5 | SAG-1.5,SAG1.5,SAG 1.5 | Hedgehog/Smoothened |
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... | |||
T70178 | Sonidegib metabolite M25 | ||
Sonidegib metabolite M25 is a smoothened (SMO) antagonist. | |||
T22958 | M 25 | Others | |
M 25 is a Smoothened (Smo) receptor antagonist. | |||
T16843 | Saridegib | IPI-926,Patidegib | Others |
Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway. | |||
T26723 | AZD8542 | AZD-8542,AZD 8542 | |
AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic. | |||
T71299 | M-25 | ||
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. | |||
T23307 | SANT 2 | SANT-2 | Others |
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM). | |||
T24400 | LEQ-506 HCl (1204975-42-7 free base) | LEQ-506,LEQ-506 dihychloride,NPVLEQ 506,LEQ506,LEQ-506 HCl,LEQ 506 | |
LEQ506 is an orally bioavailable small-molecule Smoothened antagonist. It also has a potential antineoplastic activity. | |||
T71520 | LEQ-506 | ||
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce... | |||
T61895 | AZD7254 | ||
AZD7254 is an oral effective Smoothened (SMO) inhibitor, and the EC50 of sonic Hh protein (shh) is 1.0 nM. | |||
T61897 | SMO-IN-1 | ||
SMO-IN-1 (Compound 15) is an oral effective Smoothened (SMO) inhibitor. The EC50 value of sonic Hh protein (shh) is 89 nM. | |||
T25918 | Palmitoyl-L-aspartic acid | L-N-Palmitoylaspartic acid | |
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec... | |||
T63387 | SMO-IN-3 | ||
SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance... | |||
T38767 | MRT-83 hydrochloride | ||
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t... | |||
T62772 | TPB15 | ||
TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein ... | |||
T35537 | Hedgehog Antagonist VIII | ||
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcript... | |||
T70693 | MRT-92 HCl salt | ||
MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell prolifera... | |||
T35539 | IHR-Cy3 | IHR-Cy3 | |
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Ch... | |||
T35538 | HPI-1 (hydrate) | HPI-1 hydrate | |
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss o... | |||
T36910 | PF 04449913 maleate | ||
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discov... | |||
T70195 | NL-103 | ||
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibito... | |||
T35558 | KAAD-Cyclopamine | ||
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T2825 | Cyclopamine | 11-Deoxojervine | Hedgehog/Smoothened , Endogenous Metabolite , Smo |
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. | |||
T3363 | Jervine | Iervin,11-Ketocyclopamine,Jerwiny | Hedgehog/Smoothened , Smo |
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signa... | |||
T3912 | Saikosaponin B1 | Others | |
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro. | |||
T10085 | 20(S)-Hydroxycholesterol | 20α-Hydroxycholesterol | Smo |
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo). |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01528 | IHH Protein, Human, Recombinant (His) | Human | E. coli |
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target gen... | |||
TMPH-02540 | GRK2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to... |