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T63429 |
SMO-IN-2
|
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Hedgehog/Smoothened
|
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SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c... |
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T63387 |
SMO-IN-3
|
|
|
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SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance... |
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T61897 |
SMO-IN-1
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|
|
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SMO-IN-1 (Compound 15) is an oral effective Smoothened (SMO) inhibitor. The EC50 value of sonic Hh protein (shh) is 89 nM. |
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T3460 |
HhAntag
|
|
Hedgehog/Smoothened
,
Smo
|
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HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity. |
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T23027 |
MRT-10
|
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Hedgehog/Smoothened
|
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MRT-10 is a Smoothened (Smo) receptor antagonist. |
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T14188 |
ALLO-2
|
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Hedgehog/Smoothened
,
Smo
|
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ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. |
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T12109 |
MRT-83
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Smo
|
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MRT-83 is a potent Smo antagonist. |
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T9531 |
MRT-14
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Smo
|
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MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies. |
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T6891 |
MK-4101
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Apoptosis
,
Hedgehog/Smoothened
,
Smo
|
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MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells. |
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T2450 |
SANT-1
|
SANT 1 |
Hedgehog/Smoothened
,
Smo
|
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SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). |
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T2666 |
Taladegib
|
LY2940680 |
Hedgehog/Smoothened
,
Smo
|
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Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. |
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T6514 |
Glasdegib
|
PF-04449913 |
Hedgehog/Smoothened
,
Smo
|
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Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. |
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T24159 |
IHR-1
|
IHR 1 |
Smo
|
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IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. |
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T1810 |
Purmorphamine
|
Shh Signaling Antagonist VI |
Hedgehog/Smoothened
,
Smo
,
Autophagy
|
|
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation. |
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T1779 |
SAG
|
Smoothened Agonist (SAG) HCl,Smoothened Agonist |
Hedgehog/Smoothened
,
Smo
|
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SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. |
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T11838 |
LEQ506
|
NVP-LEQ506 |
Smo
|
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T2299 |
BMS-833923
|
XL-139 |
Apoptosis
,
Hedgehog/Smoothened
,
Smo
|
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BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM). |
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T22814 |
GSA-10
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Hedgehog/Smoothened
|
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Smoothened (Smo) receptor agonist |
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T5465 |
PF-5274857
|
PF-5274857 freebase |
Smo
|
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PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t... |
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T9532 |
MRT-81
|
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Others
|
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MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance... |
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T1926 |
Sonidegib
|
Erismodegib,NVP-LDE225,LDE225 |
Hedgehog/Smoothened
,
Smo
|
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Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
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T0107 |
Halcinonide
|
Halcimat,Halciderm,Halcinonida,SQ-18566 |
Glucocorticoid Receptor
,
Smo
|
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Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations. |
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T2250 |
DY131
|
DY 131,GSK 9089,DY-131 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Smo
|
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DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ. |
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T15727 |
Sonidegib diphosphate
|
NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate |
Smo
|
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Sonidegib diphosphate (LDE225 diphosphate) is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively). |
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T124384 |
Jasmonic acid
|
(-)-Jasmonic acid |
|
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Jasmonic acid (JA) is a phytohormone and plant growth regulator involved in plant defense and growth and development.Jasmonic acid plays an important role in signaling, inducing the MAP kinase cascade pathway and calcium... |
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T2590 |
Vismodegib
|
Erivedge,GDC-0449,RG 3616 |
Hedgehog/Smoothened
,
ABC
,
Autophagy
|
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Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM). |
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T5144 |
Desmopressin acetate (16679-58-6 free base)
|
Desmopressin acetate,DDAVP |
Vasopressin Receptor
|
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Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyur... |
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T39910 |
Desmorpholinyl Navitoclax-NH-Me
|
Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me |
BCL
|
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Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. |
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T13523 |
Bronchospasmolytic agent 1
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Others
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Bronchospasmolytic agent 1 is a flutropium bromide compound and acts as a bronchospasmolytic agent. |
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T39818 |
Desmorpholinyl Quizartinib-PEG2-COOH
|
Desmorpholinyl Quizartinib-PEG2-COOH |
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Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal ta... |
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T131458 |
Acetyl-alpha-desmotroposantonin
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Acetyl-alpha-desmotroposantonin is a useful organic compound for research related to life sciences and the catalog number is T131458. |
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T23769 |
AZSMO-23
|
AZSMO 23 |
|
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AZSMO-23 is the human ether-a-go-go-related gene (hERG)-encoded potassium channel activator that acts by blocking hKv4.3-hKChIP2.2, hCav3.2, and hKv1.5 and activating hCav1.2/β2/α2δ. |
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T32269 |
Jasmone, (E)-
|
EINECS 228-410-7 |
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Jasmone, (E)- is a type of perfuming agent. |
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T131459 |
Alpha-Desmotroposantonin methylether
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alpha-Desmotroposantonin methylether is a useful organic compound for research related to life sciences and the catalog number is T131459. |
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T40880 |
(±)-Jasmonic acid
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(±)-Jasmonic acid, a plant growth regulator and derivative of α-linolenic acid, exhibits chlorophyll-lowering effects in green and etiolated barley leaf segments, while also inhibiting the elongation of rice seedlings. |
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T65308 |
Methyl jasmonate
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Methyl jasmonate is a useful organic compound for research related to life sciences. The catalog number is T65308 and the CAS number is 1211-29-6. |
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T31472 |
Dihydrojasmone lactone
|
gamma-Methyldecalactone,gamma-Methyl decalactone,4-Methyldecanolide |
|
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Dihydrojasmone lactone is a biochemical. |
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T1503 |
Esmolol hydrochloride
|
ASL8052,Esmolol HCl |
Mitophagy
,
Adrenergic Receptor
,
Autophagy
|
|
Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension. Esmolol has not been linked to instances of clinically apparent drug induced liver injury. |
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T36941 |
Sporidesmolide III
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Sporidesmolide III is a cyclodepsipeptide originally isolated from P. chartarum. |
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T74190 |
(-)-Jasmonoyl-L-isoleucine
|
|
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(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile), an enantiomer of (+)-JA-L-Ile [1], is an inactive endogenous hormone. |
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T40465 |
SAG dihydrochloride
|
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Hedgehog/Smoothened
|
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SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo. |
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T4211 |
SAG hydrochloride (912545-86-9(free base))
|
Smoothened Agonist HCl |
Hedgehog/Smoothened
|
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SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist. |
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T24754 |
Hh-Ag1.5
|
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
|
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Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
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T64351 |
GI-560192
|
RL-0070933 |
Smo
|
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GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. |
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T15019L |
CUR61414 hydrochloride
|
CUR61414 hydrochloride (334998-36-6 Free base) |
Hedgehog/Smoothened
|
|
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively... |
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T70178 |
Sonidegib metabolite M25
|
|
|
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Sonidegib metabolite M25 is a smoothened (SMO) antagonist. |
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T22958 |
M 25
|
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Others
|
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M 25 is a Smoothened (Smo) receptor antagonist. |
|
T35539 |
IHR-Cy3
|
IHR-Cy3 |
|
|
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available.
Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Ch... |
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T26723 |
AZD8542
|
AZD-8542,AZD 8542 |
|
|
AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic. |
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T35563 |
PF-5274857 hydrochloride
|
|
|
|
PF-5274857 hydrochloride is a potent, orally active, selective, blood-brain barrier permeable Smo antagonist with IC50=5.8 nM and Ki=4.6 nM. It has research potential in a variety of tumors including brain tumors and bra... |
