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T3713 |
BAY-876
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transporter
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BAY-876 is an orally active and selective inhibitor of glucose transporter 1 (GLUT1, IC50= 2 nM). BAY-876 exhibits >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 also inhibits glycolytic metabol... |
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T8500 |
VLX600
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OXPHOS
,
Mitochondrial Metabolism
,
Autophagy
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VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells. |
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T0239 |
Lonidamine
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AF1890,DICA,Diclondazolic Acid |
Apoptosis
,
Hexokinase
,
Mitochondrial Metabolism
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Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). |
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T37985 |
D-Fructose-6-phosphate (sodium salt hydrate)
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D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base) |
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D-Fructose-6-phosphate (sodium salt hydrate) is a sugar intermediate in the glycolytic pathway produced by the isomerization of glucose 6-phosphate by glucose phosphate isomerase, and is used in cancer research. |
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T62758 |
PKM2 activator 2
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PKM
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PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol... |
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T36491 |
POMHEX
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Glucokinase
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Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycoly... |
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T40063 |
CBR-470-1
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Nrf2
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CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect... |
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T36953 |
Naphthofluorescein
|
Naphthafluorescein |
HIF
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Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhib... |
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T17224 |
VER-246608
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Dehydrogenase
,
PDK
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VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an... |
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T23953 |
Dactylarin
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Altersolanol B |
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Dactylarin is a cytotoxic antibiotic. Dactylarin isolated from Dactylaria lutea. Dactylarin interacts with thiols, which explains its inhibitory effect on the above glycolytic enzymes. |
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T76115 |
Pyruvate kinase
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Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] . |
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T76097 |
Aldolase
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Aldolase, a glycolytic enzyme and component of the VATPase complex, catalyzes the decomposition of fructose 1,6-diphosphate into dihydroxyacetone and glyceraldehyde 3-phosphate [1]. |
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T70032 |
NCI-006
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|
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NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m... |
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T76111 |
Hexokinase (ScHEX1)
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|
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Hexokinase (ScHEX1), a glycolytic enzyme, is inhibited by n-acetylglucosamine, which causes it to detach from the mitochondrial outer membrane. This detachment activates the NLRP3 inflammasome [1]. |
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T76154 |
Triosephosphate isomerase
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Triosephosphate isomerase (TPI), a glycolytic enzyme, efficiently catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The catalytic site of TPI is located at the dimer inter... |
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T60858 |
MOPIPP
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MOPIPP is a novel indolebased chalcone that can cross the blood-brain barrier. MOPIPP inhibits the tumor progression agaisnt glioblastoma cells. MOPIPP induces cellular vacuolization as well as increases autophagosomes n... |
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T76152 |
Glucose 6-phosphate isomerase
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|
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Glucose 6-phosphate isomeras (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved gl... |
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T37119 |
1,2,3-Trioctanoyl-rac-glycerol-13C3
|
1,2,3-Trioctanoyl-rac-glycerol-13C3 |
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1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains ... |
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T79723 |
PDK-IN-2
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|
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PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells. It promotes mitochondrial bioenergetics, reduces glycolytic activity, and triggers apo... |
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T79285 |
TRAP1-IN-1
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HSP
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TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and p... |
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T76122 |
Phosphoglycerate kinase
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|
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Phosphoglycerate kinase (PGK) is a glycolytic enzyme that catalyzes the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP, resulting in the production of 3-phosphoglycerate (3-PG) and ... |
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T35874 |
CC260
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CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell ... |
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T35683 |
2-deoxy-D-Glucose-13C6
|
2-deoxy-D-Glucose-13C6 |
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2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits h... |
