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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9032 | MGH-CP1 | Others | |
MGH-CP1 is a potent and selective inhibitor TEAD palmitoylation. It exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively. | |||
T23372 | SMIFH2 | Others | |
SMIFH2 is formin homology 2 (FH2) domains inhibitor. | |||
T2055 | WS3 | EGFR , IκB/IKK | |
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | |||
TQ0105 | CAY10650 | Phospholipase | |
CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM). | |||
T41286 | N6-Isopentenyladenosine | Endogenous Metabolite , Autophagy | |
N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different... | |||
T4507 | Chlorphenesin | Adermykon,Chlorophenesin,Gecophen | Antibacterial , Antifungal , Histamine Receptor |
Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent. | |||
T21981 | Phthalazinone pyrazole | Aurora Kinase | |
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. | |||
T8793 | CBS1117 | Influenza Virus | |
CBS1117 is a virus entry inhibitor (IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1)). It interferes with the hemagglutinin (HA)-mediated fusion process. | |||
T3171 | GSK137647A | GSK 137647 | GPR |
GSK137647A (GSK 137647) is a selective FFA4 agonist. | |||
T9350 | IMP-1088 | Others , DNA/RNA Synthesis | |
IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual. | |||
T5994 | KPT-6566 | Others | |
KPT-6566 is a novel selective covalent pin1 inhibitor, KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain,and has anti-cancer activity. | |||
T12854 | SBI-797812 | NAMPT | |
SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM). | |||
T0459 | Sulindac | Arthrocine,MK-231,Clinoril,Sulindac sulfoxide | COX , Autophagy |
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... | |||
T4102 | Goserelin acetate | Fertilan,ICI-118630 acetate,Zoladex | Apoptosis , GNRH Receptor |
Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer. | |||
T1725 | Y-27632 dihydrochloride | Y-27632 2HCl | ROCK , Apoptosis |
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. | |||
T24488 | MLS000545091 | MLS-000545091,MLS 000545091 | |
MLS000545091 is a potent and selective human epithelial 15-lipoxygenase-2 mixed-type inhibitor. | |||
T15266 | F16 | (E)-4-(3-indolylvinyl)-N-methylpyridinium iodide | Others |
F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide) inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial. | |||
T21252 | DHMB | 2,3-Dihydroxy-4-Methoxybenzaldehyde | Others |
DHMB (2,3-Dihydroxy-4-Methoxybenzaldehyde) exerts protective effects on intestinal epithelial cells. DHMB exhibits anti-inflammatory and antifungal capacity. | |||
T17216 | Valspodar | PSC 833 | P-gp |
Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer. | |||
T0843 | Triamterene | Ademine,SKF8542 | Sodium Channel , GPCR19 |
Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. | |||
T19826 | Rabeprazole | LY307640 | Potassium Channel , STAT |
Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers. | |||
T4252 | ML327 | c-Myc , Autophagy | |
ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT). | |||
T0175 | Amiloride hydrochloride | Amiloride HCl,MK-870 hydrochloride | Apoptosis , Serine Protease , Sodium Channel , TRP/TRPV Channel |
Amiloride hydrochloride (Amiloride HCl) is an effective sodium channel blocker of epithelial. | |||
T19552 | RPH-2823 | Others | |
RPH-2823, a basic amphotericin analog, is diuretic, natriuretic, and potassium-preserving, inducing a dose-dependent decrease in SCC and an increase in trans-epithelial resistance. | |||
TP2324 | Thymulin | Immunology/Inflammation related | |
Thymulin is a peptide hormone which is mainly produced by thymic epithelial cells and it has immune-modulatory and anti-inflammatory effects | |||
T61702 | SRI-37240 | ||
SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, ... | |||
T5700 | PDD00017273 | Others | |
PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries. | |||
T6848 | GSK1016790A | GSK101 | Calcium Channel , TRP/TRPV Channel |
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells. | |||
T9601 | Tepotinib hydrochloride(1 : x) | c-Met/HGFR , P-gp , ABC | |
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations. | |||
T12788 | R(+)-IAA-94 | R(+)-Methylindazone | Chloride channel |
R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef). | |||
T2391 | Camostat mesylate | FOY-S980,FOY305,Camostat mesilate | Serine/threonin kinase , SARS-CoV , Sodium Channel |
Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function. | |||
T24997 | ABT-510 acetate | ABT 510 acetate | Apoptosis |
ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i... | |||
T71704 | Navamepent | RX-10045 | Others |
Navamepent (RX-10045) is an analog of resolvin E1 (a dietary-3 polyunsaturated fatty acid metabolite), which has potent anti-inflammatory activity that reduces corneal inflammation, epithelial damage, and accelerates cor... | |||
T4319 | Hispidol | (Z)-Hispidol | TNF |
Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM. | |||
T5872 | Faltan | Folpet | Antifungal |
Faltan (Folpet),a widely used dicarboximide fungicide,induces tumors in the mouse gastrointestinal tract,primarily in the duodenum,and is also cytotoxic effect on human bronchial epithelial cells. | |||
T5850 | Benzamil | Benzamil (hydrochloride) | Na+/Ca2+ Exchanger , Sodium Channel |
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. | |||
T11064 | DMT1 blocker 2 | Others | |
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo. | |||
T35337L | Teduglutide acetate | Glucagon Receptor | |
Teduglutide acetate, a GLP-2 analogue, maximizes small intestinal mucosal hypertrophy. Teduglutide acetate partially restores small intestinal epithelial function through an altered distribution of claudin-10, facilitati... | |||
T22833 | H-9 dihydrochloride | EGFR , 5-HT Receptor , PKA | |
H-9 dihydrochloride is a potent protein kinase (PKA) inhibitor.H-9 Dihydrochloride significantly reduces the excitatory response to 5-HT at low concentrations.H-9 Dihydrochloride affects pharyngeal activity.H-9 Dihydroch... | |||
T60372 | ALDH3A1-IN-1 | ||
ALDH3A1-IN-1 (Compound 18) is a potent ALDH3A1 inhibitor with an IC 50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination... | |||
T62281 | PARP-1-IN-2 | PARP | |
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel... | |||
T73300 | AXL-IN-13 | FLT , TAM Receptor , PDGFR , TGF-beta/Smad | |
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh... | |||
T77701 | FL118 | FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin | Survivin |
FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin s... | |||
T38752 | EW-7195 | ALK , TGF-beta/Smad | |
EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i... | |||
T13920L | Terlipressin Acetate | Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous | Vasopressin Receptor |
Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-in... | |||
T19710 | Ciglitazone | Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878 | Apoptosis , p38 MAPK , PPAR |
Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia... | |||
T1185 | Rofecoxib | MK 966,MK-0966 | COX |
Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of pheny... | |||
T11793 | KY-05009 | Wnt/beta-catenin | |
KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o... | |||
T41231 | GP 1a | Cannabinoid Receptor , PERK , Arrestin | |
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and incr... | |||
TP1565L1 | Foxy-5 Ammonium Salt | Foxy-5 Ammonium Salt(881188-51-8 Free base) | Wnt/beta-catenin |
Foxy-5 Ammonium Salt is a WNT5A agonist, a mimetic peptide of WNT5A, a non-classical member of the Wnt family.Foxy-5 Ammonium Salt triggers cytoplasmic free calcium signaling without affecting β-catenin activation and in... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3862 | Irigenin | NF-κB , Integrin | |
Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
T5758 | Sphondin | COX , Prostaglandin Receptor | |
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. | |||
T4S0969 | Obtusifolin | Antioxidant , NF-κB | |
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be... | |||
T1221 | Acetylcholine chloride | ACh chloride,Pilofrin | Calcium Channel , Endogenous Metabolite , AChR |
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen... | |||
T5S1882 | Songorine | Napellonine,Zongorine,Bullatine G | Others , GABA Receptor |
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. | |||
T0518 | Methacycline hydrochloride | Rondomycin,Methacycline HCl | ribosome , Antibacterial , Antibiotic |
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. | |||
T14046 | Anandamide | (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | Cannabinoid Receptor , Endogenous Metabolite |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy... | |||
TN1198 | 19-Hydroxybufalin | Others | |
19-Hydroxybufalin is a natural product, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells. | |||
T3796 | Betulinaldehyde | Betulinic aldehyde,Betulinal,Betunal | Apoptosis , Antibacterial |
Betulinaldehyde (Betunal) has the inhibition of Saccharomyces sp and alpha-glucosidase. Betulinaldehyde induces apoptosis in mouse B16 2F2 cells. Betulinaldehyde has anti-proliferative activity against mouse +SA mammary ... | |||
T5281 | Skatole | Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole | AhR , p38 MAPK , Aryl Hydrocarbon Receptor , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal |
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. | |||
T4136 | Lapachol | Bethabarra wood,CI75490,Greenhartin,Tecomin | Others , Influenza Virus , Antibacterial , Parasite , Antifungal |
Lapachol (CI75490) has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is an inhibitor of epithelial tumors in Drosophila melanogaster heterozygote. | |||
T7982 | 3,6-Dihydroxyflavone | Others | |
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. | |||
T3330 | Trans-Trimethoxyresveratrol | trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene | Reactive Oxygen Species |
trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy... | |||
T67710 | 3-Indoleacrylic acid | Endogenous Metabolite | |
3-Indoleacrylic acid is a metabolite of tryptophan produced by Peptostreptococcus species. 3-Indoleacrylic acid has a beneficial effect on intestinal epithelial barrier function and mitigates inflammatory responses by im... | |||
T5S0056 | Coptisine chloride | Q-100696,NSC-119754 | Indoleamine 2,3-Dioxygenase (IDO) , Influenza Virus , Antibacterial |
1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds. | |||
TN1433 | Batatasin III | FAK , Others , Akt | |
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-... | |||
T2S0690 | Ecliptasaponin A | Echinocystic acid-3-o-glucoside | Others |
1. Ecliptasaponin A (Echinocystic acid-3-o-glucoside) has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-... | |||
T2S2108 | Coixol | 6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA | Others , Antibacterial |
1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate fo... | |||
T4869 | D-Allose | β-D-Allopyranose,D-(+)-ALLOSE | Others , Endogenous Metabolite |
D-Allose (β-D-Allopyranose) is a rare naturally occurring monosaccharide known to exert anti-proliferative effects on cancer cells. The effects of D-Allose on the cellular membranes of hormone-refractory prostate cancer ... | |||
T4S1383 | Escin IA | Aescin IA,Escin IA;Aescin IA,Escin IA | HIV Protease |
Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ... | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
T5004 | Hyaluronic acid sodium | Sodium Hyaluronate | Others |
Hyaluronic acid sodium (Sodium Hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsu... | |||
T1183 | Retinol | all-trans-Retinol,Vitamin A,Vitamin A1,Alphalin | Others |
Retinol (Alphalin) and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune r... | |||
T3889 | Platycodin D | Prostaglandin Receptor , AMPK | |
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1... | |||
T3123 | Allicin | ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection | |
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus... | |||
T3795 | Corilagin | Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy | |
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B... | |||
TN1567 | Delphinidin chloride | Estrogen Receptor/ERR , VEGFR | |
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va... | |||
T6S1315 | Oroxylin A | 6-Methoxybaicalein,Baicalein 6-methyl ether | Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy |
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v... | |||
TN1273 | 7,4'-Dihydroxyflavone | 4',7-Dihydroxyflavone | NF-κB , COX , HDAC , CCR , NOD |
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2. | |||
T4S0797 | Berberine | Berberin,Umbellatine | Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy |
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3.... | |||
T35749 | Thymohydroquinone | Thymoquinol | Antioxidant , Reactive Oxygen Species |
Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulate... | |||
T5S0313 | Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside | Liquiritin apioside | Others , TNF |
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as p... | |||
T7711 | Uridine triphosphate | UTP,Uridine 5'-triphosphate | Others , Endogenous Metabolite |
Uridine triphosphate (Uridine 5'-triphosphate) increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. | |||
TN3686 | Coccinic acid | Others | |
Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual ... | |||
T82310 | Glomeratide A | ||
Glomeratide A, a benzophenone C-glucoside, exhibits hepatoprotective properties and safeguards rat liver epithelial stem-like cells from d-galactosamine-induced hepatotoxicity. | |||
TN3380 | Alloisoimperatorin | AChR | |
Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoi... | |||
T75694 | Lacto-N-neotetraose | ||
Lacto-N-neotetraose (LNnT), an endogenous metabolite, inhibits TNF-α-induced IL-8 secretion in immature epithelial cells, exhibits anti-inflammatory activity, and enhances wound closure [1] [2] [4]. | |||
T82032 | Isoglobotriaose | Gala-3Galb-4Glc | |
Isoglobotriaose (Gala-3Galb-4Glc), a mammalian tissue glycosphingolipid, is a Globotriaose analogue. The ganglioside derivatives of Isoglobotriaose and Globotriaose differ in their small intestine distribution: isoglobot... | |||
T75661 | Thymopentin acetate | ||
Thymopentin acetate, primarily secreted by the epithelial cells of the thymic cortex and medulla, serves as an effective immunomodulatory agent. It possesses a short plasma half-life of 30 seconds and significantly enhan... | |||
TN1646 | Flemiphilippinin A | Others | |
Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity... | |||
T37974 | (S)-Coriolic acid | 13(S)-HODE | Lipoxygenase , Mitochondrial Metabolism , PPAR |
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation i... | |||
TN2977 | 3-O-trans-p-Coumaroyltormentic acid | Caspase , Antifection | |
3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, ... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-03722 | EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is XP_005576740.1. | |||
TMPY-03762 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1. | |||
TMPY-00533 | EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) | Cynomolgus,Rhesus | HEK293 Cells |
EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is G7PM59. | |||
TMPY-02939 | EpCAM/TROP1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
EpCAM/TROP1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.2 kDa and the accession number is O55159. | |||
TMPY-00534 | EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant | Cynomolgus,Rhesus | HEK293 Cells |
EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is G7PM59. | |||
TMPY-03003 | EpCAM/TROP1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
EpCAM/TROP1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.8 kDa and the accession number is O55159. | |||
TMPY-01300 | EpCAM/TROP1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.84 kDa and the accession number is P16422. | |||
TMPY-05587 | EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 30.7 kDa and the accession number is P16422. | |||
TMPY-03244 | E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.8 kDa and the accession number is Q9R0T4. | |||
TMPY-04041 | E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.4 kDa and the accession number is Q9R0T4. | |||
TMPK-00737 | EVA-1/MPZL2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epitheli... | |||
TMPK-00738 | EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epitheli... | |||
TMPJ-01372 | Cornulin Protein, Human, Recombinant (His) | Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter... | |||
TMPJ-00468 | KLK10 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
KLK10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 34 KDa and the accession number is AAH02710.1. | |||
TMPY-02137 | E-Cadherin/Cadherin-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78 kDa and the accession number is P09803. | |||
TMPH-01297 | DDR1 Protein, Human, Recombinant (aa 21-417, His) | Human | HEK293 Cells |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival ... | |||
TMPJ-00019 | CCL28 Protein, Human, Recombinant | Human | E. coli |
Chemokine (C-C Motif) Ligand 28 (CCL28) is a novel chemokine that shares the most homology with CCL27/CTACK. CCL28 shows chemotactic activity for resting CD4, CD8 T-cells and eosinophils. It Binds to CCR3 and CCR10 and i... | |||
TMPY-01766 | EpCAM/TROP1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
EpCAM/TROP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.1 kDa and the accession number is Q99JW5. | |||
TMPY-05052 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62 kDa and the accession number is A0A0U2ZQU7. | |||
TMPY-05656 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1. | |||
TMPK-00509 | E-Cadherin/Cadherin-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelia... | |||
TMPY-05117 | EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is P16422. | |||
TMPY-05601 | EpCAM/TROP1 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 56 kDa and the accession number is P16422. | |||
TMPY-00785 | EpCAM/TROP1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54 kDa and the accession number is P16422. | |||
TMPY-04953 | EpCAM/TROP1 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is P16422. | |||
TMPY-06849 | EpCAM/TROP1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
EpCAM/TROP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 53.81 kDa and the accession number is NP_002345.1. | |||
TMPH-01163 | CXCL5 Protein, Human, Recombinant (His) | Human | E. coli |
CXCL5 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00155 | Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated | Human | HEK293 Cells |
Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also ... | |||
TMPY-03221 | Intrinsic Factor Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the ... | |||
TMPY-00322 | DEC-205 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp... | |||
TMPJ-00375 | HGF Protein, Human, Recombinant (His) | Human | HEK293 Cells |
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti... | |||
TMPJ-00651 | CD155/PVR Protein, Human, Recombinant (aa 21-343, His) | Human | HEK293 Cells |
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entr... | |||
TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d... | |||
TMPJ-00842 | FGF-2 Protein, Rat, Recombinant | Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. ... | |||
TMPY-02258 | Kallikrein 3/KLK3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that i... | |||
TMPY-04329 | Vimentin Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers ... | |||
TMPJ-00662 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i... | |||
TMPJ-00038 | IL-7 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a... | |||
TMPY-02779 | Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) | Human | Baculovirus Insect Cells |
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant... | |||
TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including ce... | |||
TMPY-00566 | CCL18 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its... | |||
TMPJ-00051 | IL-3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit... | |||
TMPY-04552 | AKT1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ... | |||
TMPK-00661 | IL-22 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab... | |||
TMPH-03478 | PrgI Protein, Salmonella typhimurium, Recombinant (His & SUMO) | Salmonella typhimurium | E. coli |
Required for invasion of epithelial cells. | |||
TMPK-01194 | IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | E. coli |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab... | |||
TMPK-00649 | CDH6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Cadherin 6 (CDH6) is an adhesion molecule localizing to the endometrial luminal epithelial cell surface in the mid-secretory/receptive phase and knockdown of CDH6 in the Ishikawa cells (receptive endometrial epithelial c... | |||
TMPJ-00073 | FGF-7/KGF Protein, Human, Recombinant | Human | E. coli |
Fibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival a... | |||
TMPH-02608 | Corticoliberin Protein, Mouse, Recombinant (His & KSI) | Mouse | E. coli |
Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile. | |||
TMPK-00828 | Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire... | |||
------------------------ More ------------------------ |
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L2540 | Gut Microbial Metabolite Library | 614 compounds | |
A unique collection of 614 gut microbial metabolites which can be used for HTS and HCS; | |||
L2195 | Anti-Prostate Cancer Compound Library | 2070 compounds | |
2070 compounds associated with prostate cancer that can be used for high-throughput and high-content screening. |