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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T38831 | Endoplasmic reticulum dye 1 | ||
Endoplasmic reticulum dye 1 is a highly effective live cell imaging agent used for detecting exocytotic events occurring at the plasma membrane. This compound exhibits minimal cytotoxicity and is resistant to photobleach... | |||
T2654 | GSK2656157 | Apoptosis , PERK , Autophagy | |
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 kinases. | |||
T2614 | GSK2606414 | Apoptosis , PERK , Autophagy | |
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM). | |||
T21976 | ONO-8130 | Prostaglandin Receptor | |
ONO-8130 is an orally available antagonist of EP1 receptor. | |||
T11221 | ERAP1-IN-1 | Others | |
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activi... | |||
T22436 | Takeda-6d | VEGFR | |
Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM. | |||
T8982 | RH01687 | Others | |
RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress. | |||
T6183 | ISRIB (trans-isomer) | ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB | Apoptosis , PERK , Autophagy |
ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM). | |||
T9110 | Ceapin-A7 | Others | |
Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions. | |||
T9349 | IXA4 | IRE1 | |
IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function. | |||
T16873 | SERCA2a activator 1 | Calcium Channel | |
SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart. | |||
T8901 | YUM70 | Apoptosis , GPR , HSP | |
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate... | |||
T9564 | IRE1α kinase-IN-1 | IRE1 | |
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph... | |||
T13416 | ZX-29 | ALK | |
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect. | |||
T1198 | Tetracaine hydrochloride | Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl | Calcium Channel , Sodium Channel |
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use... | |||
T19663 | Triheptanoin | UX 007,IND106011,UX007,UX-007,IND 106011,IND-106011 | Others |
Triheptanoin (IND 106011) is a fatty acid metabolic modulator. It potentially for the treatment of fatty acid oxidation disorders and GLUT1. | |||
T0787 | Butylhydroxyanisole | BHA,E320,Butylated hydroxyanisole | Antioxidant , Ferroptosis , Reactive Oxygen Species |
Butylhydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. | |||
T6993 | Tauroursodeoxycholate sodium | Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC) | Apoptosis , ERK , Caspase |
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. | |||
T7373 | CDN1163 | Calcium Channel | |
CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). | |||
T7540 | 2,5-Di-tert-butylhydroquinone | BHQ | Calcium Channel , Lipoxygenase , COX |
2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor. | |||
T27579 | ICL-CCIC-0019 | ICL CCIC 0019 | AChR |
ICL-CCIC-0019 is an inhibitor of choline kinase alpha (ChoKα). ICL-CCIC-0019 induces G1 arrest, endoplasmic reticulum stress, and apoptosis of cancer cell lines. | |||
T8863 | VK-II-36 | Others | |
VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor. | |||
T24239 | K201 | K-201,JTV 519,JTV-519,K 201 | Calcium Channel |
K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors. | |||
T13219 | TTA-Q6 | Calcium Channel | |
TTA-Q6 is a selective T-type Ca2+ channel antagonist with potential antitumor and immunomodulatory activity for the treatment of neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cell... | |||
T8452 | Dantrolene | Others | |
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. | |||
T4400 | DIM-C-pPhOH | CDIM8 | Apoptosis , Others |
DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... | |||
T6267 | Lomitapide | AEGR-733,BMS-201038 | CETP |
Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring... | |||
T14080 | AA147 | ATF6-activator-147 | Others |
AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially trigge... | |||
T60924 | Verosudil | AR-12286 | ROCK |
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ... | |||
T1435 | Praziquantel | Pyquiton,Droncit,Biltricide | Calcium Channel , Antibiotic , Parasite |
Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculatur... | |||
T4054 | Dantrolene sodium hemiheptahydrate | Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene | Calcium Channel , Autophagy |
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t... | |||
T16550 | PKR-IN-C16 | Others | |
PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the A... | |||
T6509 | Galeterone | VN-124-1,TOK-001,VN/124-1,VN 124 | P450 , Androgen Receptor |
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a... | |||
T5148 | Atosiban acetate | RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 | Oxytocin Receptor , Vasopressin Receptor |
Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... | |||
T23709 | AlphaSYN-IN-NAB2 | alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2 | |
alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ... | |||
T12009 | Telomerase-IN-1 | Telomerase | |
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apopto... | |||
T33087 | Lysyl-aspartyl-glutamyl-leucine | Kdel sequence,Lys-asp-glu-leu | |
Lysyl-aspartyl-glutamyl-leucine maintains type II surface membrane proteins in the endoplasmic reticulum. | |||
T68320 | L594881 HCl | ||
L594881, also known as 3',4'-Dichlorobenzamil or DCB, is an inhibitor of Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. L594881 can inhibit Na+/Ca2+ exchanger, Na+ transport and sar... | |||
T26383 | 3',4'-Dichlorobenzamil HCl | ||
3',4'-Dichlorobenzamil HCl is an inhibitor of Na+ transport, Na+/Ca2+ exchanger, sarcoplasmic reticulum Ca2+ release channels. | |||
T34601 | Sekdel sequence | Ser-glu-lys-asp-glu-leu | |
Sekdel sequence, as a signal, leads to retention of at least two proteins in the endoplasmic reticulum of animal cells. | |||
T70516 | ToP-DNJ | ||
ToP-DNJ is a selective inhibitor of endoplasmic reticulum α-Glucosidase II, exhibiting antiflaviviral activity. | |||
T73536 | QM295 | ||
QM295 is a selective, reversibly reactive thiol inhibitor of endoplasmic reticulum oxidation 1 (ERO1), utilized in research related to endoplasmic reticulum stress. | |||
T21131 | NASTRp | Naphthol AS-TR phosphate | |
NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress. | |||
T32082 | Histidyl-aspartyl-glutamyl-leucine | His-asp-glu-leu,Hdel sequence | |
HDEL intracellular distribution is characteristic of plant endoplasmic reticulum (ER). | |||
T40385 | Eroonazole | ||
Eroonazole is a new small molecule disrupter of endoplasmic reticulum structure. | |||
T19181 | Afegostat | D-Isofagomine,Isofagomine | Others |
T26830 | BK 129 | BK-129,BK129 | |
BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum. | |||
T15599 | Istaroxime hydrochloride | PST2744 hydrochloride | Others |
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. | |||
T16998 | Tauroursodeoxycholate dihydrate | Taurolite dihydrate,TUDCA dihydrate,UR 906 dihydrate | ERK , Caspase |
Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decreases the expression of apoptosis molecules, such as caspase-... | |||
T11732 | JTV-519 hemifumarate | K201 hemifumarate | MELK |
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5A2461 | Bufotalin | Bufotaline | Apoptosis , Others , Reactive Oxygen Species |
1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads. | |||
T2532 | Tauroursodeoxycholate | Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA | Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite |
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode... | |||
T0200 | α-Lipoic Acid | Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid | Apoptosis , NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite |
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme ... | |||
T22468 | 1-Deoxymannojirimycin hydrochloride | Others , Influenza Virus , HIV Protease | |
α-mannosidase I inhibitor | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... | |||
TN1560 | Dehydroeffusol | 5-Ethenyl-1-Methylphenanthrene-2,7-Diol,Dehydro Effusol | MMP , ERK , GPR , Others |
Dehydroeffusol (Dehydro Effusol) possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reti... | |||
T15027 | Cyclopiazonic acid | Calcium Channel | |
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce... | |||
TN1721 | Gypenoside L | ERK , p38 MAPK , Calcium Channel , NF-κB , ROS | |
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... | |||
T2930 | α-Lipoic Acid | Lipoic acid,Alphalipoic acid | NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite |
α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an es... | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... | |||
T11363 | Ganoderic acid F | Others | |
T37512 | Cis-4-Hydroxy-L-proline | Endogenous Metabolite | |
cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress. | |||
T4395 | Daphylloside | Others | |
Daphylloside, and asperuloside can be suggested as endoplasmic reticulum stress regulators. | |||
T13430 | ABTL-0812 | α-Hydroxylinoleic acid | Others |
ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity. | |||
T14293 | Annonacin | Others | |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarco... | |||
T19253 | Cyclic ADP-ribose | cADPR | Calcium Channel |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med... | |||
TN1645 | Flavokawain C | NADPH-oxidase , MAPK , AChR | |
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticu... | |||
TN3719 | Cristacarpin | p38 MAPK , ROS , CDK , Antifection , p53 | |
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which ev... | |||
TN5440 | Catechin-7-O-xyloside | Catechin 7-O-β-D-xylopyranoside | Others |
Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells. | |||
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-med... | |||
T75637 | Demethylcantharidate disodium | ||
Demethylcantharidate disodium, an endogenous metabolite, demonstrates significant anticancer efficacy against various cancers by inducing apoptosis in hepatocellular carcinoma cells through endoplasmic reticulum (ER) str... | |||
T39605 | β-D-Glucopyranosyl abscisate | ABA-GE,β-D-Glucopyranosyl abscisate,(S)-cis,trans-Abscisicacidglucosylester | |
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable conjugate of abscisic acid (ABA), which predominantly accumulates in the vacuole and likely in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl ab... | |||
T82753 | Celangulin | ||
Celangulin, an insecticidal component derived from Celastrus angulatus, functions by activating calcium channels on the plasma membrane, which leads to an increase in intracellular Ca2+ due to influx from the external en... | |||
T72429 | α-Lipoic Acid sodium | Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium | |
α-Lipoic Acid (Thioctic acid) sodium, an essential cofactor for mitochondrial enzyme complexes, serves as an antioxidant. It suppresses NF-κB-dependent activation of HIV-1 LTR [1] [2] [3] and triggers ER (endoplasmic ret... | |||
T75540 | Ipomoeassin F | ||
Ipomoeassin F, a selective and potent inhibitor of endoplasmic reticulum (ER) protein translocation, targets the Sec61 complex's pore-forming subunit (Sec61α) at the ER membrane. It inhibits the ER membrane translocation... | |||
T35577 | Phosphatidylserines (bovine) | ||
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-04413 | IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) | Human | Baculovirus Insect Cells |
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 86 kDa and the accession number is O75460-1. | |||
TMPY-04753 | IRE1 Protein, Human, Recombinant (aa 465-977) | Human | Baculovirus Insect Cells |
IRE1 Protein, Human, Recombinant (aa 465-977) is expressed in Baculovirus insect cells. The predicted molecular weight is 58.3 kDa and the accession number is O75460-1. | |||
TMPY-00535 | ERP44 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ERP44 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.7 kDa and the accession number is A0A384MEE7. | |||
TMPY-02890 | ERP27 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide... | |||
TMPJ-01268 | ERP27 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Endoplasmic reticulum resident protein 27, also known as ER protein 27, C12orf46 and ERP27, is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family. ERP27 contains one thio... | |||
TMPH-02059 | ATP2A2 Protein, Human, Recombinant (N-His) | Human | E. coli |
ATP2A2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 52.3 kDa and the accession number is P16615. | |||
TMPH-00436 | Calreticulin Protein, Cricetulus griseus, Recombinant (His) | Chinese hamster | P. pastoris (Yeast) |
Calreticulin Protein, Cricetulus griseus, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 48.1 kDa and the accession number is Q8K3H7. | |||
TMPH-02559 | Calreticulin Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
Calreticulin Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.3 kDa and the accession number is P14211. | |||
TMPH-02558 | Calreticulin Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Calreticulin Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.3 kDa and the accession number is P14211. | |||
TMPY-00992 | ERAP2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum ... | |||
TMPH-03105 | Calreticulin Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | P. pastoris (Yeast) |
Calreticulin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P28491. | |||
TMPJ-01013 | VCP Protein, Human, Recombinant (His) | Human | E. coli |
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxi... | |||
TMPJ-00720 | TXNDC12 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defens... | |||
TMPH-03766 | ATP2A2 Protein, Human, Recombinant (C-His) | ||
ATP2A2 Protein, Human, Recombinant (C-His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is P16615. | |||
TMPJ-01124 | PDIA6 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and br... | |||
TMPJ-01384 | MAN1B1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is invo... | |||
TMPY-04125 | PTP1B Protein, Human, Recombinant (His) | Human | E. coli |
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c... | |||
TMPJ-01221 | UBE2J2 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen... | |||
TMPH-01535 | INSIG2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol... | |||
TMPH-02638 | HSPA5 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its i... | |||
TMPH-00201 | BK polyomavirus (BKPyV) VP2 Protein (His) | BKPyV | E. coli |
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ... | |||
TMPH-01420 | SAR1A Protein, Human, Recombinant (GST) | Human | E. coli |
Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent a... | |||
TMPH-01293 | ERP29 Protein, Human, Recombinant (GST) | Human | E. coli |
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. | |||
TMPH-02110 | SEC11C Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | |||
TMPH-02365 | JC polyomavirus (JCV) Minor capsid protein VP2 (His) | JCPyV | E. coli |
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ... | |||
TMPJ-00935 | PDIA3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
PDIA3 protein is also known as Protein disulfide-isomerase A3. It is a protein that in humans is encoded by the PDIA3 gene.PDIA3 is an enzyme that belongs to the endoplasmic reticulum and interacts with lectin chaperones... | |||
TMPH-02601 | C1RL Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. C1RL Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.5 ... | |||
TMPY-02376 | BNIP3L Protein, Human, Recombinant | Human | E. coli |
The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t... | |||
TMPH-00789 | Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc) | HaPyV | E. coli |
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on... | |||
TMPH-01299 | EMC4 Protein, Human, Recombinant (His) | Human | E. coli |
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates prot... | |||
TMPY-03438 | Calsequestrin 1 Protein, Human, Recombinant | Human | E. coli |
Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction,... | |||
TMPH-02619 | CKAP4 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
High-affinity epithelial cell surface receptor for APF.; Mediates the anchoring of the endoplasmic reticulum to microtubules. CKAP4 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N... | |||
TMPH-02620 | CKAP4 Protein, Mouse, Recombinant (His & MBP) | Mouse | Baculovirus Insect Cells |
High-affinity epithelial cell surface receptor for APF.; Mediates the anchoring of the endoplasmic reticulum to microtubules. CKAP4 Protein, Mouse, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-... | |||
TMPH-00870 | ILVBL Protein, Human, Recombinant (His) | Human | E. coli |
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation ... | |||
TMPY-01605 | STIM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human ... | |||
TMPH-01313 | EIF4G1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F c... | |||
TMPK-00937 | CKAP4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor ... | |||
TMPK-00936 | CKAP4 Protein, Human, Recombinant (His) | Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor ... | |||
TMPJ-00923 | Calnexin Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), a... | |||
TMPY-02050 | DDOST Protein, Human, Recombinant | Human | E. coli |
The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane t... | |||
TMPH-02971 | Vimentin Protein, Mouse, Recombinant (His & Myc) | Mouse | HEK293 Cells |
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin... | |||
TMPK-00074 | IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I o... | |||
TMPH-01390 | G6PC Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis ... | |||
TMPH-02111 | SRP72 Protein, Human, Recombinant (GST) | Human | E. coli |
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might intera... | |||
TMPH-01389 | G6PC Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis ... | |||
TMPH-03634 | GRA3 Protein, Toxoplasma gondii, Recombinant (His) | Toxoplasma gondii | E. coli |
Direct host-parasite interaction occurs at the cytoplasmic faces of the parasitophorous vacuole membrane (PVM) and the host endoplasmic reticulum (ER) membrane via GRA3 and host CAMLG association. Direct insertion of GRA... | |||
TMPH-02970 | Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc) | Mouse | E. coli |
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin... | |||
TMPH-03446 | SSA1 Protein, S. cerevisiae, Recombinant (His & Myc) | Saccharomyces cerevisiae | E. coli |
May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the... | |||
TMPK-00075 | IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I o... | |||
TMPY-02768 | Selenoprotein M Protein, Human, Recombinant (His) | Human | E. coli |
Selenoprotein M is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine M is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenopr... | |||
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カタログ番号 | 製品名 | ||
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L9700 | Endoplasmic Reticulum Stress Compound Library | 193 compounds | |
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); |