Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).
説明 | AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). |
ターゲット&IC50 | Dopamine uptake:71 nM |
In vivo | In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1]. |
別名 | 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride |
分子量 | 379.87 |
分子式 | C21H24ClF2NO |
CAS No. | 202646-03-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 33.33 mg/mL (87.74 mM), Sonication is recommended.
DMSO: 125 mg/mL (329.06 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AHN 1-055 hydrochloride 202646-03-5 GPCR/G Protein Neuroscience Dopamine Receptor AHN 1 055 hydrochloride transporter Dopamine DAT Dopamine Transporter Inhibitor AHN 1-055 Hydrochloride AHN 1055 hydrochloride 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride SLC6A3 uptake AHN 1-055 inhibit inhibitor