| T1644 |
Dopamine hydrochloride
|
Dopamine HCl,ASL279 |
Ferroptosis
,
Dopamine Receptor
,
5-HT Receptor
,
Endogenous Metabolite
|
|
Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b... |
| T10164 |
5,6-Dihydroxyindole
|
Dopamine lutine |
Endogenous Metabolite
|
|
5,6-Dihydroxyindole (Dopamine lutine) is a melanin precursor and has a broad-spectrum antibacterial, antiviral, antifungal, antiparasitic activity. It has cytotoxic effects and is strongly toxic against various pathogens... |
| T4710 |
3-Methoxytyramine hydrochloride
|
3-O-methyl Dopamine hydrochloride,3-O-methyl Dopamine hydrochloride) |
Others
,
Endogenous Metabolite
,
Drug Metabolite
|
|
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be found primarily in human br... |
| TN7066 |
Coryneine
|
2-(3,4-dihydroxyphenyl)ethyl-trimethylazanium,Quaternary dopamine,Trimethyl(3,4-dihydroxyphenethyl)aminium,Dopamine methiodide |
Others
|
|
Coryneine (Trimethyl(3,4-dihydroxyphenethyl)aminium) is a quaternary ammonium derivative of dopamine derived from aconite root. |
| T73775 |
Dopamine 3-O-sulfate
|
|
|
|
Dopamine 3-O-sulfate, primarily found in plasma, serves as a biomarker for identifying aromatic amino acid decarboxylase (AADC) deficiency [1]. |
| T6S0923 |
Hypericin
|
Hypericine,Cyclosan |
Apoptosis
,
Antiviral
,
Influenza Virus
,
Tyrosine Kinases
,
Antibacterial
,
PKC
|
|
1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL... |
| T4S0779 |
D-tetrahydropalmatine
|
|
Others
,
Dopamine Receptor
|
|
D-Tetrahydropalmatine is a organic cation transporter 1 (OCT1) inhibitor, it can obviously inhibit the uptake of monocrotaline (MCT) in MDCK-hOCT1 cells and isolate rat primary hepatocytes, and attenuate the viability re... |
| TN6552 |
5,7-Dimethoxyluteolin
|
|
Dopamine Receptor
|
|
5,7-Dimethoxyluteolin is a natural product from Hovenia acerba. 5,7-Dimethoxyluteolin is a dopamine transporter (DAT) activator with an EC50 of 3.417 μM. |
| T0848 |
L-DOPA
|
Levodopa,3,4-Dihydroxyphenylalanine |
Dopamine Receptor
,
Endogenous Metabolite
|
|
L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai... |
| T15686 |
L-741626
|
3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole |
Dopamine Receptor
|
|
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). |
| T2874 |
Tetrahydroberberine
|
Tetrahydroberberine THB,Canadine |
Dopamine Receptor
,
5-HT Receptor
|
|
Tetrahydroberberine (Canadine) is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors. |
| T0043 |
Octodrine
|
2-Amino-6-methylheptane,6-Methyl-2-heptylamine,1,5-Dimethylhexylamine |
Dopamine Receptor
|
|
Octodrine (2-Amino-6-methylheptane) is a local anesthetic and vasoconstrictor, but mainly as a pharmaceutical intermediate of Octamylamine. |
| T14853 |
Cabergoline
|
FCE-21336 |
Dopamine Receptor
,
5-HT Receptor
,
Autophagy
|
|
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal a... |
| T2793 |
Tetrahydropalmatine
|
DL-Tetrahydropalmatine,Rotundine |
Apoptosis
,
Others
,
Dopamine Receptor
|
|
Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic attack in rats. |
| TQ0176 |
(-)-Isocorypalmine
|
Tetrahydrocolumbamine,(S)-Tetrahydrocolumbamine |
Dopamine Receptor
,
Antifungal
|
|
(-)-Isocorypalmine ((S)-Tetrahydrocolumbamine), a natural product isolated from Corydalis chaerophylla, has significant antifungal activity. |
| TN1217 |
2'-O-Methylisoliquiritigenin
|
|
Dopamine Receptor
,
5-HT Receptor
,
GABA Receptor
|
|
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... |
| T6648 |
Rotundine
|
Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine |
Dopamine Receptor
,
5-HT Receptor
|
|
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| T3369 |
Nuciferine
|
(-)-Nuciferine,VLT 049,Sanjoinine E |
Dopamine Receptor
,
5-HT Receptor
|
|
Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. |
| T6780 |
Benzamide
|
Amid kyseliny benzoove,Phenylcarboxyamide,Benzoylamide |
PARP
,
Endogenous Metabolite
|
|
Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid. |
| T0076 |
Paliperidone
|
9-hydroxyrisperidone |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older... |
| T2917 |
Tetrahydropalmatine hydrochloride
|
1-Tetrahydropalmitine HCl,Gindarine hydrochloride |
Others
,
Dopamine Receptor
|
|
Tetrahydropalmatine hydrochloride (Gindarine hydrochloride) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo). It is a potent muscle relaxant. |
| T5S2059 |
Glaucine
|
|
Calcium Channel
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
PDE
|
|
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... |
| T1045 |
Trimipramine maleate
|
Surmontil maleate |
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... |
| T81710 |
N-Acetyldopamine dimer-3
|
|
|
|
N-Acetyldopamine dimer-3 (Compound 11), a naturally occurring chemical, is present in the species Aspongopus chinensis [1]. |
| T40158 |
N-acetyldopamine
|
NADA |
|
|
N-acetyldopamine (NADA) is a catecholamine utilized by insects as a precursor for sclerotization, a process that strengthens their cuticle. |
| T7060 |
Amantadine
|
1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine |
Others
|
|
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. |
| T2S1778 |
DL-Goitrin
|
Goitrin |
Others
|
|
DL-Goitrin is a potent antithyroid compound found naturally in crucifers. DL-Goitrin is responsible for the induction of glutathione S-transferases. DL-Goitrin is a moderate inhibitor of purified bovine adrenal dopamine ... |
| T4907 |
3,4-Dihydroxybenzeneacetic acid
|
DOPAC,3,4-Dihydroxyphenylacetic acid |
Endogenous Metabolite
|
|
3,4-Dihydroxybenzeneacetic acid (3,4-Dihydroxyphenylacetic acid) is the main metabolite of dopamine. |
| T6004 |
Tetrahydropapaverine hydrochloride
|
Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride |
Hydroxylase
|
|
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons. |
| T0689 |
D-Phenylalanine
|
|
Endogenous Metabolite
,
Monocarboxylate transporter
|
|
D-Phenylalanine, a necessary aromatic amino acid, is a precursor of thyroxine, dopamine, melanin, and noradrenaline (norepinephrine). |
| T3S0507 |
Homovanillic acid
|
Homovaniuic acid,Vanilacetic acid,Vanillacetic acid |
Others
,
Endogenous Metabolite
|
|
Homovanillic acid (Vanillacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, growth hormone deficiency, celiac disease, and sepiapterin reductase deficiency. |
| TN2252 |
Syrosingopine
|
|
Dopamine Receptor
|
|
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. |
| T5S1389 |
Escin IB
|
|
5-HT Receptor
,
NO Synthase
|
|
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes... |
| TN1081 |
Hirsuteine
|
|
Dopamine Receptor
|
|
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes. |
| T10146 |
4-Hydroxyderricin
|
|
Dehydrogenase
,
MAO
|
|
|
| T5S0802 |
Palmatine
|
Berbericinine,Burasaine |
Indoleamine 2,3-Dioxygenase (IDO)
,
AChR
,
AChE
,
Aurora Kinase
|
|
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,... |
| T3578 |
Pyridoxal phosphate
|
PLP,PAL-P,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase
,
Endogenous Metabolite
|
|
Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and d... |
| T5S2357 |
Acetylcorynoline
|
(+)-Corynoline Acetate,O-Acetylcorynoline |
Antifungal
|
|
1. Acetylcorynoline (O-Acetylcorynoline) has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3... |
| T25900 |
Oosponol
|
Lenzitin |
|
|
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects. |
| T8269 |
3-Methoxytyramine
|
|
Others
,
Endogenous Metabolite
|
|
3-Methoxytyramine, an extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator. |
| TMA2419 |
Catalponol
|
|
cAMP
|
|
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP. |
| TN2149 |
Reynosin
|
|
BCL
,
Others
,
TNF
|
|
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regu... |
| TN6685 |
Homovanillic Acid Sulfate
|
|
|
|
Homovanillic acid sulfate is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.In psychiatry and neuroscience, brain and cerebrospinal fluid levels of homovanillic acid ar... |
| T15255 |
Etilevodopa
|
Levodopa ethyl ester,L-DOPA ethyl ester |
Others
|
|
Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levo... |
| TN3607 |
Catalpalactone
|
|
cAMP
|
|
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone c... |
