Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.
説明 | CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities. |
In vitro | CRA-026440 hydrochloride exhibits anti-proliferation effect on HUVEC endothelial cells with GI50 of 1.41 μM. CRA-026440 hydrochloride leads to the accumulation of acetylated histone and acetylated tubulin, thus inhibiting the growth of tumor cells and inducing cell apoptosis. CRA-026440 hydrochloride inhibits angiogenesis in vitro in a dose-dependent manner[1]. |
In vivo | CRA-026440 hydrochloride (100 mg/kg; intravenous injection; daily; three consecutive days) resulted in a significant decrease in tumor growth in mice carrying HCT116 or U937 human tumor xenografts[1]. |
別名 | CRA-026440 hydrochloride(847460-34-8 Free base) |
分子量 | 456.92 |
分子式 | C23H25ClN4O4 |
CAS No. | 847459-98-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.43 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CRA-026440 hydrochloride 847459-98-7 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC 847460-34-8 847460-34-8 Free base CRA-026440 Hydrochloride CRA 026440 Hydrochloride CRA026440 Hydrochloride CRA-026440 hydrochloride(847460-34-8 Free base) Inhibitor inhibitor inhibit