Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 67,500 |
5 mg | 在庫あり | ¥ 143,000 |
10 mg | 在庫あり | ¥ 224,000 |
25 mg | 在庫あり | ¥ 333,000 |
50 mg | 在庫あり | ¥ 450,000 |
100 mg | 在庫あり | ¥ 603,500 |
説明 | MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP[1]. |
ターゲット&IC50 | mTOR:0.2 nM(Kd) |
別名 | MTI-31, LXI-15029 |
分子量 | 474.55 |
分子式 | C26H30N6O3 |
CAS No. | 1567915-38-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8.33 mg/mL (17.55 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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MTI-31 1567915-38-1 PI3K/Akt/mTOR signaling mTOR mTOR kinase inhibitor tissue factor LXI 15029 mTORC2 mTOR inhibitor Inhibitor EGFR mutant cancer mTOR-TF axis Mammalian target of Rapamycin MTI31 apoptosis inhibit MTI 31 mTORC1 lipid metabolism LXI-15029 LXI15029 tumor microenvironment inhibitor