mTORC2 | TargetMol

カタログ番号	製品名	別名	ターゲット
T35343	MTI-31	MTI-31,LXI-15029	mTOR
	MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a...		mTOR
T11728	JR-AB2-011		mTOR
	JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 μM) and is cytotoxic in glioblastoma [1].		mTOR
T2475	KU-0063794		mTOR
	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.		mTOR
T6319	OSI-027	ASP4786,OSI027	DNA-PK , PI3K , mTOR , Autophagy
	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.		DNA-PK , PI3K , mTOR , Autophagy
T6045	Torin 1		DNA-PK , PI3K , mTOR , Autophagy
	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.		DNA-PK , PI3K , mTOR , Autophagy
T9156	CDC25B-IN-2		Phosphatase , mTOR
	BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.		Phosphatase , mTOR
T12123	MTOR inhibitor-3		mTOR
			mTOR
T8649	TMBIM6 antagonist-1	BAX-inhibitor-1,BIA	mTOR
	TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor		mTOR
T36200	AZD 3147		mTOR
	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.		mTOR
T6732	WYE-687		p38 MAPK , PI3K , Src , mTOR
	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fol...		p38 MAPK , PI3K , Src , mTOR
T14552	Dactolisib Tosylate	BEZ235 Tosylate,NVP-BEZ 235 Tosylate	PI3K , mTOR
	Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR. dactolisib Tosylate exhibits IC50 values of 4, 75, 7, and 5 nM for PI3Kα, β, γ, and δ, respectively. dactolisib Tosylate inhibi...		PI3K , mTOR
T6731	WYE-354		Apoptosis , PI3K , mTOR , Autophagy
	WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ ...		Apoptosis , PI3K , mTOR , Autophagy
T6730	WAY-600	WAY600	VEGFR , PI3K , Src , mTOR
	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold...		VEGFR , PI3K , Src , mTOR
T2414	Torkinib	PP 242	Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
	Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).		Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
T3514	CZ415		mTOR
	CZ415 is a potent and highly selective mTOR inhibitor.		mTOR
T3541	CC-115	CC 115	DNA-PK , PI3K , mTOR
	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).		DNA-PK , PI3K , mTOR
T1961	Vistusertib	AZD2014	Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.		Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
T6103	VS-5584	SB2343,VS 5584,VS5584	PI3K , mTOR
	VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.		PI3K , mTOR
T2706	Palomid 529	P529,SG 00529	Apoptosis , mTOR
	Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.		Apoptosis , mTOR
T6030	XL388		P450 , PI3K , mTOR
	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.		P450 , PI3K , mTOR
T1859	AZD-8055		Apoptosis , mTOR , Autophagy
	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.		Apoptosis , mTOR , Autophagy
T1970	Gedatolisib	PF-05212384,PKI-587	PI3K , mTOR
	Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.		PI3K , mTOR
T6510	GDC-0349	RG-7603	PI3K , mTOR , Autophagy
	GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.		PI3K , mTOR , Autophagy
T7014	Voxtalisib	XL765,SAR245409	DNA-PK , PI3K , mTOR
	Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.		DNA-PK , PI3K , mTOR
T2235	Dactolisib	BEZ235,NVP-BEZ235	ATM/ATR , PI3K , mTOR , Autophagy
	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).		ATM/ATR , PI3K , mTOR , Autophagy
T6143	PI-103	PI103,PI 103	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T6346	WYE-132	WYE 125132,WYE125132,WYE-125132	Apoptosis , mTOR
	WYE-125132 (WYE-132 (WYE-125132)) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.		Apoptosis , mTOR
T3351	Onatasertib	CC223,CC 223,CC-223	Apoptosis , c-Fms , DNA-PK , FLT , PI3K , mTOR
	Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor ce...		Apoptosis , c-Fms , DNA-PK , FLT , PI3K , mTOR
T2265	Bimiralisib	5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2	Others , PI3K , S6 Kinase , mTOR
	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to ...		Others , PI3K , S6 Kinase , mTOR
T28439	PP30	PP 30,PP-30
	PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.
T11328	FT-1518		mTOR
			mTOR
T21816	OXA-01
	OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.
T31223	DCBCI0901	DCBCI-0901,DCBCI 0901
	DCBCI0901 is an inhibitor of phosphatidylinositide 3-kinase (PI3K), raptor-mTOR (mTOR complex 1 or mTORC1) and rictor-mTOR (mTOR complex 2 or mTORC2) with potential antineoplastic activity.
T61505	CC-115 hydrochloride
	CC-115 hydrochloride is a potent dual inhibitor of DNA-PK and mTOR kinase, exhibiting IC50 values of 13 nM and 21 nM, respectively. It effectively blocks both mTORC1 and mTORC2 signaling pathways.
T30441	BI-860585	BI860585
	BI-860585 is an inhibitor of Raptor-Mammalian Target of Rapamycin (mTOR) Complex 1 (mTOR Complex 1; mTORC1) and rictor-mTOR Complex 2 (mTOR Complex 2; mTORC2), with potential Anti-tumor activity.
T61659	CC214-2
	CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the...
T39959	RMC-6272	RM-006,RMC-6272
	RMC-6272 (RM-006) is a bi-steric inhibitor that selectively targets mTORC1, displaying potent and selective (> 10-fold) inhibition over mTORC2. Compared to Rapamycin, RMC-6272 demonstrates enhanced inhibition of mTORC1 a...
T39958	(32-Carbonyl)-RMC-5552
	(32-Carbonyl)-RMC-5552 is a highly effective mTOR inhibitor, exhibiting inhibitory effects on both mTORC1 and mTORC2 substrate phosphorylation. Specifically, it significantly suppresses the phosphorylation of p-P70S6K-(T...
T72270	WYE-687 dihydrochloride
	WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC 50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibi...
T6143L	PI-103 Hydrochloride
	PI-103 Hydrochloride is a potent dual inhibitor of PI3K and mTOR, demonstrating inhibitory IC50 values of 8 nM for p110α, 88 nM for p110β, 48 nM for p110δ, 150 nM for p110γ, 20 nM for mTORC1, and 83 nM for mTORC2, respec...
T80546	Thioether-cyclized helix B peptide, CHBP		mTOR
	Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTOR C1 and activation of mTOR C2 [1].		mTOR
T80547	Thioether-cyclized helix B peptide, CHBP TFA		mTOR
	Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP. This form enhances metabolic stability and exhibits renoprotective effects by promoting autophagy, achieved through the inhibitio...		mTOR

Compounds

MTI-31

T35343

Synonym: MTI-31,LXI-15029

Synonym: ASP4786,OSI027

Target: DNA-PK, PI3K, mTOR, Autophagy

Torin 1

T6045

Synonym:

Target: DNA-PK, PI3K, mTOR, Autophagy

CDC25B-IN-2

T9156

Synonym:

Target: Phosphatase, mTOR

Synonym: BAX-inhibitor-1,BIA

Target: p38 MAPK, PI3K, Src, mTOR

Dactolisib Tosylate

T14552

Synonym: BEZ235 Tosylate,NVP-BEZ 235 Tosylate

Target: Apoptosis, PI3K, mTOR, Autophagy

WAY-600

T6730

Synonym: WAY600

Target: VEGFR, PI3K, Src, mTOR

Torkinib

T2414

Synonym: PP 242

Target: Apoptosis, Mitophagy, PI3K, mTOR, Autophagy

Target: DNA-PK, PI3K, mTOR

Vistusertib

T1961

Synonym: AZD2014

Target: Apoptosis, Akt, PI3K, S6 Kinase, mTOR, Autophagy

VS-5584

T6103

Synonym: SB2343,VS 5584,VS5584

Target: PI3K, mTOR

Palomid 529

T2706

Synonym: P529,SG 00529

Target: Apoptosis, mTOR

XL388

T6030

Synonym:

Target: P450, PI3K, mTOR

AZD-8055

T1859

Synonym:

Target: Apoptosis, mTOR, Autophagy

Gedatolisib

T1970

Synonym: PF-05212384,PKI-587

Target: PI3K, mTOR, Autophagy

Voxtalisib

T7014

Synonym: XL765,SAR245409

Target: DNA-PK, PI3K, mTOR

Dactolisib

T2235

Synonym: BEZ235,NVP-BEZ235

Target: ATM/ATR, PI3K, mTOR, Autophagy

PI-103

T6143

Synonym: PI103,PI 103

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

WYE-132

T6346

Synonym: WYE 125132,WYE125132,WYE-125132

Target: Apoptosis, mTOR

Onatasertib

T3351

Synonym: CC223,CC 223,CC-223

Target: Apoptosis, c-Fms, DNA-PK, FLT, PI3K, mTOR

Bimiralisib

T2265

Synonym: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2

Target: Others, PI3K, S6 Kinase, mTOR

Synonym: DCBCI-0901,DCBCI 0901

Synonym: RM-006,RMC-6272

Target:

(32-Carbonyl)-RMC-5552

T39958

Synonym:

Target:

WYE-687 dihydrochloride

Thioether-cyclized helix B peptide, CHBP

T80546

Synonym:

Target: mTOR

Thioether-cyclized helix B peptide, CHBP TFA

T80547

Synonym:

Target: mTOR

カタログ番号	製品名	Species	Expression System
TMPY-06815	SYAP1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the ...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth...

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ターゲット

阻害剤

リコンビナントタンパク質

Compounds

Recombinant Proteins