|
T3031 |
A 83-01
|
ALK5 Inhibitor IV,A8301 |
ALK
,
TGF-beta/Smad
|
|
A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult... |
|
T2109 |
SD-208
|
ALK5 Inhibitor V,SD208 |
TGF-beta/Smad
|
|
SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII. |
|
T6337 |
RepSox
|
ALK5 Inhibitor II,SJN 2511,E-616452 |
ALK
,
TGF-beta/Smad
|
|
RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells. |
|
T22560 |
ALK5 Inhibitor II (hydrochloride)
|
|
Others
|
|
ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively. |
|
T62614 |
ALK5-IN-29
|
|
|
|
ALK5-IN-29 is a selective inhibitor of activin receptor-like kinase (ALK).ALK5-IN-29 inhibits activin receptor-like kinase activity (IC50 ≤ 10 nM).AALK5-IN-29 inhibits tumour growth and can be used in the study of prolif... |
|
T62116 |
ALK5-IN-33
|
|
|
|
ALK5-IN-33 (Compound EX-10) is an orally active, selective inhibitor of ALK-5 (IC50 ≤ 10 nM). |
|
T62302 |
ALK5-IN-28
|
|
|
|
ALK5-IN-28 is a selective inhibitor of ALK-5 with an IC50 ≤ 10 nM that inhibits TGF-β-induced SMAD signalling.ALK5-IN-28 has the potential to inhibit tumour growth in vivo.ALK5-IN-28 can be used to study proliferative di... |
|
T62394 |
ALK5-IN-31
|
|
|
|
ALK5-IN-31 is a selective inhibitor of ALK-5 (IC50≤10 nM) and also inhibits TGF-β-induced SMAD signalling.ALK5-IN-31 has the potential to inhibit tumour growth in vivo.ALK5-IN-31 can be used in the study of proliferative... |
|
T62546 |
ALK5-IN-27
|
|
|
|
ALK5-IN-27 (Compound EX-04) is a potent inhibitor of ALK-5 (IC50 ≤ 10 nM). ALK5-IN-27 also inhibits ALK-2. |
|
T62615 |
ALK5-IN-30
|
|
|
|
ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM). |
|
T62393 |
ALK5-IN-25
|
|
|
|
ALK5-IN-25 (compound EX-02) is a potent inhibitor of ALK-5 (IC50<10 nM) and also inhibits ALK-2. ALK5-IN-25 can be used in cancer research. |
|
T63498 |
ALK5-IN-6
|
|
|
|
ALK5-IN-6 is a potent inhibitor of ALK5. ALK5-IN-6 has potential for TGF-β-related diseases and conditions, including but not limited to tumors, inflammatory diseases, fibrotic diseases, autoimmune diseases, etc.Among th... |
|
T64051 |
ALK5-IN-9
|
|
|
|
ALK5-IN-9 is a potent, orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation (IC50: 25 nM) and inhibits NIH3T3 cell activity (IC50: 74.6 nM). ALK5-IN-9 has shown research potential in canc... |
|
T62613 |
ALK5-IN-26
|
|
|
|
ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM). |
|
T61203 |
ALK5-IN-8
|
|
|
|
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently... |
|
T63114 |
ALK5-IN-7
|
|
|
|
ALK5-IN-7 is an effective inhibitor of ALK5. Transforming growth factor β (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation, and apoptosis through autocrine, paracri... |
|
T62117 |
ALK5-IN-34
|
|
|
|
ALK5-IN-34 is a selective, orally active inhibitor of activin receptor-like kinase (ALK), which inhibits the activity of activin receptor-like kinase (IC50 ≤ 10 nM) and also inhibits tumour growth. |
|
T62395 |
ALK5-IN-32
|
|
|
|
ALK5-IN-32 is a selective inhibitor of ALK-5 (10 nM<IC50<100 nM) and also inhibits TGF-β-induced SMAD signaling.ALK5-IN-31 has the potential to inhibit tumor growth in vivo.ALK5-IN-31 can be used in the study of prolifer... |
|
T5125 |
LY3200882
|
|
TGF-beta/Smad
|
|
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
|
T8330 |
BIO-013077-01
|
|
TGF-beta/Smad
|
|
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist. |
|
T1944 |
LDN-214117
|
|
ALK
,
TGF-beta/Smad
|
|
LDN-214117 is a potent and selective ALK2 inhibitor. |
|
T1800 |
GW788388
|
GW 788388 |
ALK
,
TGF-beta/Smad
|
|
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities. |
|
T5197 |
BIBF0775
|
|
ALK
,
TGF-beta/Smad
|
|
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). |
|
T2098 |
A 77-01
|
A77-01 |
ALK
,
TGF-beta/Smad
|
|
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. |
|
T2462 |
SB-505124
|
|
ALK
,
TGF-beta/Smad
|
|
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5. |
|
T1763 |
SB 525334
|
SB525334 |
ALK
,
TGF-beta/Smad
|
|
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM). |
|
T4975 |
SM 16
|
|
ALK
,
TGF-beta/Smad
|
|
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM). |
|
T6496 |
Vactosertib
|
TEW-7197,EW-7197 |
ALK
,
TGF-beta/Smad
|
|
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... |
|
T38752 |
EW-7195
|
|
ALK
,
TGF-beta/Smad
|
|
EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i... |
|
T24897 |
TP0427736
|
TP427736,TP-0427736,TP-427736 |
TGF-beta/Smad
|
|
TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cel... |
|
T15572 |
IN-1130
|
|
ALK
|
|
IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein and p38α mitogen-activated protein kinase. |
|
T1726 |
SB-431542
|
SB 431542 |
ALK
,
TGF-beta/Smad
|
|
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiatio... |
|
T35896 |
AZ 12799734
|
AZ12799734 |
ALK
|
|
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours. |
|
T9947 |
GW-6604
|
|
PAI-1
,
ALK
,
TGF-beta/Smad
|
|
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement. |
|
T9837 |
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
|
|
ALK
|
|
Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM. |
|
T16708 |
R-268712
|
|
ALK
,
TGF-beta/Smad
|
|
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. |
|
T1900 |
LDN-212854
|
LDN212854,BMP Inhibitor III |
ALK
,
TGF-beta/Smad
|
|
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors. |
|
T1935 |
LDN193189
|
LDN-193189,DM-3189,LDN 193189 |
ALK
,
TGF-beta/Smad
|
|
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). |
|
T13138 |
TGFBR1-IN-1
|
|
ALK
|
|
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM). |
|
T15262 |
Vactosertib Hydrochloride
|
TEW-7197 Hydrochloride,EW-7197 Hydrochloride |
ALK
|
|
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50... |
|
T21637 |
SB-505124 hydrochloride
|
|
|
|
SB-505124 hydrochloride functions as a selective, concentration-dependent inhibitor targeting TGF-β Receptor type I (ALK4, ALK5, ALK7), exhibiting IC50 values of 129 nM for ALK4 and 47 nM for ALK5. Notably, it does not a... |
|
T10442 |
A 83-01 sodium salt
|
|
ALK
|
|
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1]. |
|
T63897 |
LDN193189 Tetrahydrochloride
|
|
|
|
LDN193189 Tetrahydrochloride is a selective inhibitor of BMPI-type receptors and inhibits ALK2 (IC50: 5 nM) and ALK3 (IC50: 30 nM), with weak effects on ALK4, ALK5 and ALK7 (IC50 ≥ 500 nM). |
|
T11573 |
HPN-01
|
|
Others
|
|
HPN-01 is a selective IKK inhibitor (pIC50s: 6.4, 7.0, and <4.8 for IKK-α, IKK-β, and IKK-ε). HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, ErbB2, EGFR, GS... |
|
T39104 |
Itacnosertib
|
Itacnosertib,TP-0184 |
|
|
Itacnosertib (TP-0184) is a chemical compound that acts as an inhibitor of JAK2, ACVR1 (ALK2), and ALK5, as indicated in WO2014151871. |
|
T73016 |
THRX-144644
|
|
|
|
THRX-144644, a lung-restricted ALK5 inhibitor, exhibits a potent IC50 value of 0.14 nM and circumvents systemic toxicities linked to TGFβ pathway inhibition. |
|
T78790 |
J-1048
|
|
|
|
J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Smad signaling pathway [1]. |
|
T74660 |
M4K2234
|
|
|
|
M4K2234 (compound 26b), an ALK2 inhibitor, demonstrates selective inhibition of ALK2 and ALK5 with IC50 values of 5 nM and 2144 nM, respectively. Serving as a chemical probe for ALK1 and ALK2 protein kinases, M4K2234 hol... |
|
T62559 |
TGFβRI-IN-4
|
|
|
|
TGFβRI-IN-4 is a potent, orally active TGFβ receptor type I kinase (TGFβRI) inhibitor that acts on ALK5 (IC50: 44 nM) and NIH3T3 (IC50: 42.5 nM).TGFβRI-IN-4 inhibits tumor growth and tumor weight in a xenograft tumor mod... |
|
T62301 |
J-1063
|
|
|
|
J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM). J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has poten... |
